Treelet transform analysis to identify clusters of systemic inflammatory variance in a population with moderate-to-severe traumatic brain injury

Vijapur, Sushupta M.; Vaughan, Leah; Awan, Nabil; DiSanto, Dominic; McKernan, Gina; Wagner, Amy K.

doi:10.1016/j.bbi.2021.01.026

Cited by 13 publications

(10 citation statements)

References 105 publications

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“…Yet, it remains unknown how acute cortisol profiles correspond to cortisol measurements in subsequent months post-injury, 55 particularly in the setting of ongoing inflammation post-TBI. 56 Unmeasured health and environmental post-acute factors may also influence stress and cortisol levels, including socioeconomic challenges, caregiver support, or other adverse life or health events occurring between initial hospitalization due to TBI and 6-month outcomes. As an observational study, we also cannot determine if cortisol profiles directly influence cognition or are indicators of other processes affecting cognition.…”

Section: Discussionmentioning

confidence: 99%

Acute Cortisol Profile Associations With Cognitive Impairment After Severe Traumatic Brain Injury

Barton

Kumar

Schuster

et al. 2021

Neurorehabil Neural Repair

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Background Cognitive impairments commonly occur after traumatic brain injury (TBI) and affect daily functioning. Cortisol levels, which are elevated during acute hospitalization for most individuals after severe TBI, can influence cognition, but this association has not been studied previously in TBI. Objective We hypothesized that serum and cerebral spinal fluid (CSF) cortisol trajectories over days 0–5 post-injury are associated with cognition 6-month post-injury. Methods We examined 94 participants with severe TBI, collected acute serum and/or CSF samples over days 0–5 post-injury, and compared cortisol levels to those in 17 healthy controls. N = 88 participants had serum, and n = 84 had CSF samples available for cortisol measurement and had neuropsychological testing 6 months post-injury. Group based trajectory analysis (TRAJ) was used to generate temporal serum and CSF cortisol profiles which were examined for associations with neuropsychological performance. We used linear regression to examine relationships between cortisol TRAJ groups and both overall and domain-specific cognition. Results TRAJ analysis identified a high group and a decliner group for serum and a high group and low group for CSF cortisol. Multivariable analysis showed serum cortisol TRAJ group was associated with overall cognitive composites scores ( P = .024) and with executive function ( P = .039) and verbal fluency ( P = .029) domain scores. CSF cortisol TRAJ group was associated with overall cognitive composite scores ( P = .021) and domain scores for executive function ( P = .041), verbal fluency ( P = .031), and attention ( P = .034). Conclusions High acute cortisol trajectories are associated with poorer cognition 6 months post-TBI.

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Section: Discussionmentioning

confidence: 99%

Acute Cortisol Profile Associations With Cognitive Impairment After Severe Traumatic Brain Injury

Barton

Kumar

Schuster

et al. 2021

Neurorehabil Neural Repair

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Section: Mechanisms Of Tbi-induced Alterations In Brain-gut Communicationmentioning

confidence: 99%

“…In addition to the increased release of corticoids and catecholamines, TBI induces a systemic immune response, which can progress to systemic immune response syndrome (SIRS), releasing immune mediators of inflammation (cytokines, chemokines) into the circulation (59)(60)(61)(62)(63). Systemic inflammation can persist for months in patients suffering mild (59) and severe TBI (63)(64)(65). In prospective cohort studies, TBI patients had elevated serum IL-1β, IL-6, IL-8, IL-10, and TNF-α levels over the first year after injury when compared with age-matched healthy controls (64).…”

Section: Mechanisms Of Tbi-induced Alterations In Brain-gut Communicationmentioning

confidence: 99%

Brain-gut axis dysfunction in the pathogenesis of traumatic brain injury

Hanscom¹,

Loane²,

Shea‐Donohue³

2021

Journal of Clinical Investigation

122

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“…sTN-FRII is considered to produce anti-inflammatory responses, whereas sTNFRI produces a TNF-α mediated inflammatory response. Vijapur et al (2021) found that sTNFRII, when coupled with sIL-2Ra, was a significant predictor of GCS at 6-months in multiple models.…”

Section: Il-1β Interleukin 1 Beta (Il-1βmentioning

confidence: 92%

“…TNF-α is implicated in apoptosis, inflammation, immunity, and infectious disease, and sTNFRI has been studied as a prognostic factor in a variety of illnesses (Galvani et al, 2000;Sedger & McDermott, 2014). Vijapur et al (2021) found that levels of sTNFRI, especially when coupled with sTNFRII, sIL-2Ra, and sVCAM-1, predicted 6-month GCS score (e.g., high sTNFRI predicted lower GCS at 6 months). sTNFRII.…”

Section: Il-1β Interleukin 1 Beta (Il-1βmentioning

confidence: 99%

Biomarkers of Neuroinflammation in Traumatic Brain Injury

et al. 2022

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Traumatic brain injury (TBI) is characterized by neuroinflammation and structural damage leading to symptoms and altered brain function. Biomarkers are useful in understanding neuroinflammation and correlations with TBI sequalae. The purpose of this paper is to identify and discuss biomarkers of neuroinflammation used to study TBI and its sequalae. A systematic review was conducted using PubMed, CINAHL, Embase, and Web of Science. A total of 350 articles met criteria; 70 used biomarkers. PRISMA criteria were used for Quality Assessment. Articles included reviews ( n = 17), case-control ( n = 25), cross-sectional ( n = 25) studies, and randomized controlled trials ( n = 3). Twenty-seven biomarkers were identified, including inflammasomes, cytokines, neuropeptides, complement complexes, miRNA and exosomes, and glial cell-specific proteins. Biomarkers aid in predicting morbidity and mortality and advance our understanding of neuroinflammation in TBI. This systematic review advances our understanding of the neuroinflammatory response to better enable nurses and clinicians to provide informed care of TBI patients.

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Treelet transform analysis to identify clusters of systemic inflammatory variance in a population with moderate-to-severe traumatic brain injury

Cited by 13 publications

References 105 publications

Acute Cortisol Profile Associations With Cognitive Impairment After Severe Traumatic Brain Injury

Acute Cortisol Profile Associations With Cognitive Impairment After Severe Traumatic Brain Injury

Brain-gut axis dysfunction in the pathogenesis of traumatic brain injury

Biomarkers of Neuroinflammation in Traumatic Brain Injury

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