Trees with Hepatoprotective and Cardioprotective Activities

Khan, Aisha Saleem

doi:10.1007/978-3-319-56777-8_6

Cited by 1 publication

(1 citation statement)

References 47 publications

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“…Anogeissus acuminata is rich in tannins, flavonoids and phenolic compounds and is traditionally famous for curative purposes in diabetes, hyperlipidemia, snake and scorpion bites, dysentery, skin burns and wounds, sores, boils and inflammatory conditions [24]. Crude extract of Anogeissus acuminata has been screened for its anti-HIV, antioxidant, antibacterial, antidiabetic and thrombolytic activities [19][20][21][22]25].…”

Section: Discussionmentioning

confidence: 99%

Studies to Elucidate the Mechanism of Cardio Protective and Hypotensive Activities of Anogeissus acuminata (Roxb. ex DC.) in Rodents

et al. 2020

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Anogeissus acuminata (Roxb. ex DC.) is a folkloric medicinal plant in Asia; including Pakistan; used as a traditional remedy for cardiovascular disorders. This study was planned to establish a pharmacological basis for the trivial uses of Anogeissus acuminata in certain medical conditions related to cardiovascular systems and to explore the underlying mechanisms. Mechanistic studies suggested that crude extract of Anogeissus acuminata (Aa.Cr) produced in vitro cardio-relaxant and vasorelaxant effects in isolated paired atria and aorta coupled with in vivo decrease in blood pressure by invasive method; using pressure and force transducers connected to Power Lab Data Acquisition System. Moreover; Aa.Cr showed positive effects in left ventricular hypertrophy in Sprague Dawley rats observed hemodynamically by a decrease in cardiac cell size and fibrosis; along with absence of inflammatory cells; coupled with reduced levels of angiotensin converting enzyme (ACE) and renin concentration along with increased concentrations of nitric oxide (NO) and cyclic guanosine monophosphate (cGMP). In Acute Myocardial Infarction (AMI) model; creatine kinase (CK), creatine kinase-MB (CK-MB) and lactic acid dehydrogenase (LDH levels) were found to be decreased; along with decreased necrosis; edema and recruitment of inflammatory cells histologically. In vivo and ex vivo studies of Anogeissus acuminata provided evidence of vasorelaxant; hypotensive and cardioprotective properties facilitated through blockage of voltage-gated Ca++ ion channel; validating its use in cardiovascular diseases

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