This paper summarizes the results of the flow boiling heat transfer study with ethanol in a 1.8 mm deep and 2.0 mm wide horizontal, asymmetrically heated, rectangular mini-channel. The test section with the mini-channel was the main part of the experimental stand. One side of the mini-channel was closed with a transparent sight window allowing for the observation of two-phase flow structures with the use of a fast film camera. The other side of the channel was the foil insulated heater. The infrared camera recorded the 2D temperature distribution of the foil. The 2D temperature distributions in the elements of the test section with two-phase flow boiling were determined using (1) the Trefftz method and (2) the hybrid Picard-Trefftz method. These methods solved the triple inverse heat conduction problem in three consecutive elements of the test section, each with different physical properties. The values of the local heat transfer coefficients calculated on the basis of the Robin boundary condition were compared with the coefficients determined with the simplified approach, where the arrangement of elements in the test section was treated as a system of planar layers.