Treg-targeted efficient-inducible platform for collagen-induced arthritis treatment

Wang, Lin; Wang, Yi; Liu, Chang; He, Jiachen; He, X. T.; Zhang, Xiongjinfu; Zhu, Can; Sun, Jun; Wang, Qin; Chen, Hao; Shi, Qin

doi:10.1016/j.mtbio.2023.100557

Cited by 10 publications

(13 citation statements)

References 43 publications

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“…The MCs were isolated from the mouse spleen through Ficoll-Hypaque gradient centrifugation. 55 Effect of Met on NSCs at Different Concentrations. To determine the effects of Met on cell viability, NSCs were cultured with different concentrations of Met (0 μM, 1 μM, 5 μM, 10 μM, 50 μM, 100 μM, and 500 μM).…”

Section: ■ Experimental Methodsmentioning

confidence: 99%

The “Inner–Outer” Molecules-Loaded Fiber-Hydrogel Scaffolds Coordinate Specific Immunity and Neural Differentiation for Repairing SCI

Hu,

Luo,

Chen

et al. 2024

ACS Materials Lett.

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The treatment of spinal cord injury (SCI) remains unsatisfactory because of the inflammatory microenvironment and the limited potential for nerve regeneration. However, most treatments have focused on modulating nonspecific immunity and ignored the importance of specific immunity in SCI. In this study, an "Inner− Outer" Metformin (Met) and anti-CD80 monoclonal antibody (CD80 mAb)-loaded fiber-hydrogel scaffold (P/G-Met-CD80 mAb) was constructed through microsol-electrospinning and UV illumination methods. The P/G-Met-CD80 mAb scaffolds exhibited good biocompatibility and hydrophilicity, facilitating cell proliferation and adhesion. In addition, the scaffolds were capable of releasing CD80 mAb and Met sequentially, exerting their protected functions at different stages post-SCI in rats. The released CD80 mAb at an early stage significantly inhibited specific immune response by blocking T-cell costimulatory activation and reducing IL-2 secretion, improving the inflammatory microenvironment after SCI. Late stage-released Met recruited neural stem cells (NSCs) to the injury area and enhanced NSCs differentiation into neurons. The P/G-Met-CD80 mAb scaffolds with specific immunomodulatory functions and neurogenic potential provide a new strategy for repairing SCI in the clinic.

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Section: ■ Experimental Methodsmentioning

confidence: 99%

The “Inner–Outer” Molecules-Loaded Fiber-Hydrogel Scaffolds Coordinate Specific Immunity and Neural Differentiation for Repairing SCI

Hu,

Luo,

Chen

et al. 2024

ACS Materials Lett.

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“…Biomaterials possess the remarkable capacity to modulate immune response through their control over the abundance and efficacy of Treg and T helper 17 cells (Th17). [173,174] Tregs are powerful immunosuppressive cell, but the cytodifferentiation rate and quantity of Tregs are low, which limit its application. Antigen stimulation in RA promotes cytodifferentiation of CD4 + T cell into inflammatory cells such as Th17, reducing the proportion of Tregs/Th17.…”

Section: Adaptive Immune Cells Regulationmentioning

confidence: 99%

mentioning

confidence: 99%

Tailoring Biomaterials Ameliorate Inflammatory Bone Loss

Cheng,

Wang,

Zhou

et al. 2024

Adv Healthcare Materials

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Inflammatory diseases, such as rheumatoid arthritis, periodontitis, chronic obstructive pulmonary disease and celiac disease, disrupt the delicate balance between bone resorption and formation, leading to inflammatory bone loss. Conventional approaches to tackle this issue encompass pharmaceutical interventions and surgical procedures. Nevertheless, pharmaceutical interventions exhibit limited efficacy, while surgical treatments impose trauma and significant financial burden upon patients. Biomaterials show outstanding spatiotemporal controllability, possess a remarkable specific surface area, and demonstrate exceptional reactivity. In the present era, the advancement of emerging biomaterials has bestowed upon us more efficacious solutions for combatting the detrimental consequences of inflammatory bone loss. In this review, we list the advances of biomaterials for ameliorating inflammatory bone loss. Additionally, we summarize the advantages and disadvantages of various biomaterials‐mediated strategies. Finally, we analyze the challenges and perspectives of biomaterials. This review aims to provide new possibilities for developing more advanced biomaterials towards inflammatory bone loss.This article is protected by copyright. All rights reserved

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“…Neben dieser Funktion haben die Th17-Zellen auch einen Einfluss auf die Knochendestruktion, indem sie die Differenzierung der Osteoklasten verstärken. Für die Entstehung der RA wird unter anderem auch eine gestörte Dysbalance von Th17-Zellen und regulatorische T-Zellen (Treg) gesehen [53,55]. Treg steuern die T-Zell-vermittelte Immunantwort und sind für die Erhaltung der peripheren Immuntoleranz von Bedeutung [50,56].…”

Section: Wechselwirkungen Zwischen Intestinalem Mikrobiom Und Erworbe...unclassified

“…Zudem wird ein Schutz vor Knochensubstanzverlust mit vermehrtem Auftreten der Treg-Zellen assoziiert. Bei einer aktiven RA liegt eine Imbalance zwischen Th17 und Treg-Zellen zugunsten einer Th17 Zellantwort vor, während eine RA-Therapie zu einer Verschiebung in Richtung Treg-Zellen führt [55], was mit einer niedrigen Krankheitsaktivität und erfolgreicher Behandlung verknüpft wird [50,57].…”

Section: Wechselwirkungen Zwischen Intestinalem Mikrobiom Und Erworbe...unclassified

Rheumatoide Arthritis und das intestinale Mikrobiom – Ein potentieller Faktor in der Pathogenese der RA

Heidt,

Reuss-Borst

2023

Aktuelle Rheumatologie

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ZusammenfassungDie rheumatoide Arthritis (RA) ist eine chronische, entzündliche, systemische Autoimmunerkrankung, die chronisch progredient verläuft und zu schweren strukturellen Schäden und Funktionseinschränkungen führen kann. Ihre Pathogenese ist komplex und nicht abschließend verstanden. Neben genetischen, scheinen vor allem Umweltfaktoren eine wichtige Rolle zu spielen. Der Darm bildet die „innere Grenze“ zur Umwelt und kommt mit vielen Umweltfaktoren in Kontakt. Daher rückt der Darm in den letzten Jahren und mit ihm das Mikrobiom zunehmend (wieder) in den Fokus der Wissenschaft. Immer mehr evidente Befunde zeigen, dass die Mikrobiom-Darm-Gelenk-Achse eine wichtige Rolle bei der RA darstellt. Mikrobielle Dysbiose sowie eine intakte Darmbarriere („leaky gut“) und daraus resultierende bakterielle Translokation stellen potentielle Faktoren in der RA-Pathogenese dar. Hier fassen wir die derzeit bekannte Rolle der intestinalen Mikrobiota für Entstehung und Verlauf der RA zusammen. Wir betrachten dabei die neuesten Erkenntnisse auf dem Gebiet der Mikrobiomforschung und beschreiben den Zusammenhang zwischen intestinaler Dysbiose, intakte Barrierefunktion, bakterielle Translokation, adaptive Immunantwort sowie einen möglichen diätetischen Therapieansatz.

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Treg-targeted efficient-inducible platform for collagen-induced arthritis treatment

Cited by 10 publications

References 43 publications

The “Inner–Outer” Molecules-Loaded Fiber-Hydrogel Scaffolds Coordinate Specific Immunity and Neural Differentiation for Repairing SCI

The “Inner–Outer” Molecules-Loaded Fiber-Hydrogel Scaffolds Coordinate Specific Immunity and Neural Differentiation for Repairing SCI

Tailoring Biomaterials Ameliorate Inflammatory Bone Loss

Rheumatoide Arthritis und das intestinale Mikrobiom – Ein potentieller Faktor in der Pathogenese der RA

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