Tregs in transplantation tolerance: role and therapeutic potential

Cassano, Alexandra; Chong, Anita S.; Alegre, Maria-Luisa

doi:10.3389/frtra.2023.1217065

Cited by 5 publications

(4 citation statements)

References 254 publications

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“…Immune-mediated injury remains the major cause of late allograft rejection. In solid organ transplantation, a high Tregs/Tconvs ratio is important for maintaining tolerance [ 144 ]. Tconvs drive transplant rejection, whereas Tregs have the ability to limit their expansion [ 144 ].…”

Section: Many Faces In Pathologymentioning

confidence: 99%

“…In solid organ transplantation, a high Tregs/Tconvs ratio is important for maintaining tolerance [ 144 ]. Tconvs drive transplant rejection, whereas Tregs have the ability to limit their expansion [ 144 ]. Therefore, it is important to highlight the phenotypic characteristics of Tregs that influence their function in transplantation.…”

Section: Many Faces In Pathologymentioning

confidence: 99%

“…Therefore, it is important to highlight the phenotypic characteristics of Tregs that influence their function in transplantation. First, there is FoxP3-mediated upregulation of CCR4 and CCL3, which modulate Treg recruitment to the allograft and their proximity to Tconvs [ 144 ]. Second, the upregulation of some other Treg markers and cytokines drives a tolerogenic milieu.…”

Section: Many Faces In Pathologymentioning

confidence: 99%

“…These observations suggest the need for further studies on the role of IL-33 in Treg-mediated tolerance. Induction therapies such as basiliximab are important in preventing acute rejection soon after transplantation [ 144 ]. Basiliximab is a non-depleting IL-2 receptor antagonist that is designed to inhibit CD25 on Teffs that mediate immune graft damage and rejection [ 213 ].…”

Section: Treg-associated Cell Markers Used For Therapeutic Approachesmentioning

confidence: 99%

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Many Faces of Regulatory T Cells: Heterogeneity or Plasticity?

Blinova,

Zhdanov

2024

Cells

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Regulatory T cells (Tregs) are essential for maintaining the immune balance in normal and pathological conditions. In autoimmune diseases and transplantation, they restrain the loss of self-tolerance and promote engraftment, whereas in cancer, an increase in Treg numbers is mostly associated with tumor growth and poor prognosis. Numerous markers and their combinations have been used to identify Treg subsets, demonstrating the phenotypic diversity of Tregs. The complexity of Treg identification can be hampered by the unstable expression of some markers, the decrease in the expression of a specific marker over time or the emergence of a new marker. It remains unclear whether such phenotypic shifts are due to new conditions or whether the observed changes are due to initially different populations. In the first case, cellular plasticity is observed, whereas in the second, cellular heterogeneity is observed. The difference between these terms in relation to Tregs is rather blurred. Considering the promising perspectives of Tregs in regenerative cell-based therapy, the existing confusing data on Treg phenotypes require further investigation and analysis. In our review, we introduce criteria that allow us to distinguish between the heterogeneity and plasticity of Tregs normally and pathologically, taking a closer look at their diversity and drawing the line between two terms.

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Section: Many Faces In Pathologymentioning

confidence: 99%

Section: Many Faces In Pathologymentioning

confidence: 99%

Section: Many Faces In Pathologymentioning

confidence: 99%

Section: Treg-associated Cell Markers Used For Therapeutic Approachesmentioning

confidence: 99%

See 2 more Smart Citations