Trehalose Induces Autophagy Against Inflammation by Activating TFEB Signaling Pathway in Human Corneal Epithelial Cells Exposed to Hyperosmotic Stress

Liu, Zhao; Chen, Ding; Chen, Xin; Bian, Fang; Qin, Wenjuan; Gao, Ning; Xiao, Yangyan; Li, Jinmiao; Pflugfelder, Stephen C.; Li, Dequan

doi:10.1167/iovs.61.10.26

Cited by 42 publications

(28 citation statements)

References 61 publications

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“…These protective effects were further enhanced when rapamycin enhanced autophagy activation in hypertonic HCECs (Liu et al, 2020a). In addition, they suggest that trehalose, as an autophagy enhancer, induces autophagy antiinflammation by inhibiting Akt activation of transcription factor EB in primary HCECs exposed to high osmotic stress (Liu et al, 2020b). The mechanism of trehalose inhibition of inflammation is independent of NFκB pathway, and it may reduce stress-induced inflammation by inhibiting p38MAPK and activating autophagy (Panigrahi et al, 2019).…”

Section: Autophagy and Inflammationmentioning

confidence: 92%

Recent Developments About the Pathogenesis of Dry Eye Disease: Based on Immune Inflammatory Mechanisms

Dong

et al. 2021

Front. Pharmacol.

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Dry eye disease is a common and frequently occurring ophthalmology with complex and diverse causes, and its incidence is on the upward trend. The pathogenesis of DED is still completely clear. However, the immune response based on inflammation has been recognized as the core basis of this disease. In this review, we will systematically review the previous research on the treatment of DED in immune inflammation, analyze the latest views and research hotspots, and provide reference for the prevention and treatment of DED.

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Section: Autophagy and Inflammationmentioning

confidence: 92%

Recent Developments About the Pathogenesis of Dry Eye Disease: Based on Immune Inflammatory Mechanisms

Dong

et al. 2021

Front. Pharmacol.

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“…It has also been shown that osmoprotectants also reduce matrix metalloproteinase (MMP) synthesis and oxidative stress and can regulate the autophagic process [ 45 , 46 , 47 ]. Overall, osmoprotectants appear effective in preventing ocular surface cell apoptosis induced by DED.…”

Section: Types and Roles Of Ingredients Used In Tear Substitutesmentioning

confidence: 99%

Artificial Tears: Biological Role of Their Ingredients in the Management of Dry Eye Disease

Labétoulle

Benítez-del-Castillo²,

Barabino

et al. 2022

IJMS

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Dry eye disease (DED) is the most common ocular surface disease, characterized by insufficient production and/or instability of the tear film. Tear substitutes are usually the first line of treatment for patients with DED. Despite the large variety of tear substitutes available on the market, few studies have been performed to compare their performance. There is a need to better understand the specific mechanical and pharmacological roles of each ingredient composing the different formulations. In this review, we describe the main categories of ingredients composing tear substitutes (e.g., viscosity-enhancing agents, electrolytes, osmo-protectants, antioxidants, lipids, surfactants and preservatives) as well as their effects on the ocular surface, and we provide insight into how certain components of tear substitutes may promote corneal wound healing, and/or counteract inflammation. Based on these considerations, we propose an approach to select the most appropriate tear substitute formulations according to the predominant etiological causes of DED.

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“…Melatonin-loaded polymer polyvinyl caprolactam-polyvinyl acetate-polyethyleneglycol graft copolymer micelles ameliorated hyperosmolarity-induced ocular surface damage of DED via phosphated and tension homology deleted on chromosome ten-induced kinase 1-mediated mitophagy [ 46 ]. Trehalose, as an autophagy activator, also reduced the expression of pro-inflammatory mediators TNF-α, IL-1β, IL-6, and IL-8 via transcription factor EB (TFEB) activation in vitro DE model [ 47 ]. The active form of vitamin D3, calcitriol, also augmented autophagy flux and inhibited apoptosis and inflammation via vitamin D receptor signaling pathway to prevent ocular injury and clinical complication caused by DE [ 48 ].…”

Section: Research Progress Of Exosomes and Autophagy In Ocular Surfac...mentioning

confidence: 99%

Exosomes and autophagy in ocular surface and retinal diseases: new insights into pathophysiology and treatment

Liu

Yin

et al. 2022

Stem Cell Res Ther

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Background Ocular surface and retinal diseases are widespread problems that cannot be ignored in today’s society. However, existing prevention and treatment still have many shortcomings and limitations, and fail to effectively hinder the occurrence and development of them. Main body The purpose of this review is to give a detailed description of the potential mechanism of exosomes and autophagy. The eukaryotic endomembrane system refers to a range of membrane-bound organelles in the cytoplasm that are interconnected structurally and functionally, which regionalize and functionalize the cytoplasm to meet the needs of cells under different conditions. Exosomal biogenesis and autophagy are two important components of this system and are connected by lysosomal pathways. Exosomes are extracellular vesicles that contain multiple signaling molecules produced by multivesicular bodies derived from endosomes. Autophagy includes lysosome-dependent degradation and recycling pathways of cells or organelles. Recent studies have revealed that there is a common molecular mechanism between exosomes and autophagy, which have been, respectively, confirmed to involve in ocular surface and retinal diseases. Conclusion The relationship between exosomes and autophagy and is mostly focused on fundus diseases, while a deeper understanding of them will provide new directions for the pathological mechanism, diagnosis, and treatment of ocular surface and retinal diseases.

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Trehalose Induces Autophagy Against Inflammation by Activating TFEB Signaling Pathway in Human Corneal Epithelial Cells Exposed to Hyperosmotic Stress

Abstract: et al. Trehalose induces autophagy against inflammation by activating TFEB signaling pathway in human corneal epithelial cells exposed to hyperosmotic stress. Invest

Cited by 42 publications

References 61 publications

Recent Developments About the Pathogenesis of Dry Eye Disease: Based on Immune Inflammatory Mechanisms

Recent Developments About the Pathogenesis of Dry Eye Disease: Based on Immune Inflammatory Mechanisms

Artificial Tears: Biological Role of Their Ingredients in the Management of Dry Eye Disease

Exosomes and autophagy in ocular surface and retinal diseases: new insights into pathophysiology and treatment

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