Tremella fuciformis polysaccharide reduces obesity in high-fat diet-fed mice by modulation of gut microbiota

Abstract

Obesity is a metabolic disease associated with gut microbiota and low-grade chronic inflammation. Tremella fuciformis is a medicinal and edible fungus; polysaccharide (TP) is the main active component, which has a variety of biological activities, such as hypoglycemic and hypolipidemic. However, the anti-obesity effects and potential mechanisms of TP have never been reported. This study was conducted to elucidate the inhibitory effect of TP on high-fat diet (HFD)-induced obesity in mice. Mice were split into five groups: normal chow diet (NCD) group, NCD_TP_H group, HFD group, HFD_TP_L group and HFD_TP_H group. Our study showed that TP inhibited high-fat diet-induced weight gain and fat accumulation in mice and reduced blood glucose, hyperlipidemia and inflammation. TP also improved gut microbiota disorders by reducing the Firmicutes/Bacteroidetes ratio and modulating the relative abundance of specific gut microbiota. We also found that the anti-obesity and gut microbiota-modulating effects of TP could be transferred to HFD-fed mice via faecal microbiota transplantation (FMT), confirming that the gut microbiota was one of the targets of TP for obesity inhibition. Further studies showed that TP increased the production of short-chain fatty acids and the secretion of intestinal hormones. Our studies showed that TP inhibited obesity by modulating inflammation and the microbe-gut-brain axis, providing a rationale for developing TP to treat obesity and its complications.

Gut microbiome–serum metabolic profiles: insight into the hypoglycemic effect of Porphyra haitanensis glycoprotein on hyperglycemic mice

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Tibetan tea reduces obesity brought on by a high‐fat diet and modulates gut flora in mice

“…The gut microbiome consists of thousands of bacterial species, mainly Bacteroidota, Firmicutes, Proteobacteria, and Actinobacteria (Benahmed et al, 2021;Pung et al, 2022). The development of obesity is strongly correlated with gut microbiota, according to several researches (He et al, 2022;Kang et al, 2022;Su et al, 2022). The development of obesity is impacted by how a high-fat diet (HFD) changes the gut microbiota's composition by drastically increasing the ratio of Firmicutes to Bacteroidota (F/B) (Houtman et al, 2022;Indiani et al, 2018).…”

The Influence of Polysaccharides on Lipid Metabolism: Insights from Gut Microbiota

“…Consequently, it effectively inhibited weight gain, fat accumulation, and liver weight increase induced by HFD in mice. [ 63 ] Similarly, GLPs maintained gut barrier function, increased the production of SCFAs, and upregulated the expression of GPR43, thereby improving endotoxemia in mice. Consequently, it not only suppressed obesity, hyperlipidemia, inflammation, and fat accumulation induced by the HFD but also restored gut microbiota dysbiosis caused by the HFD.…”