Trend analysis and risk of gallbladder cancer mortality in China, 2013–2019

Nie, Chan; Yang, Tzu‐Wei; Liu, L.; Hong, Feng

doi:10.1016/j.puhe.2021.12.002

Cited by 10 publications

(7 citation statements)

References 27 publications

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“…However, the gaps between the sexes and locales continued to narrow. The trend of change in the ASMRs of GBC among Chinese residents was basically the same as that of ASIRs, which was consistent with previously published data [8,10]. In terms of sex distribution, both the ASIR and ASMR of women were higher than those of men.…”

Section: Discussionsupporting

confidence: 90%

Gallbladder Cancer Incidence and Mortality Rate Trends in China: A National Population-based Cancer Registry

Zhang,

Xu,

Zhang

et al. 2024

Preprint

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Background Gallbladder cancer is a major health concern in China, and awareness of the associated incidence and mortality rates is particularly important given the aging population. Objective To determine trends in gallbladder cancer incidence and mortality rates over 12 years and quantitatively analyze the influence of demographic factors on these rates in China Methods We performed a retrospective study of 98,860 Chinese citizens using the Chinese Cancer Registry, a national database. Gallbladder cancer incidence and mortality data pertaining to patients treated between 2005 and 2017 were collected. Joinpoint regression models were used to estimate the annual percentage change (APC) and average APC (AAPC). We used age-period-cohort analyses and decomposition methods to investigate differing trends in incidence and mortality. Results The age-standardized gallbladder cancer incidence and mortality rates in China trended downward between 2005 and 2017, with AAPCs of -2.023% and − 1.603%, respectively. The incidence rate increased with age up to 70 years and peaked at 70–79 years, while the mortality rate showed a consistent increase with age. Both incidence and mortality rates increased in more recent periods; in terms of the cohort effect, rates generally decreased in later birth years but showed a partial rise between 1982 and 1996. The crude incidence rates of gallbladder cancer according to demographic and non-demographic factors were 626.09% and − 526.09% respectively (366.23% and − 266.23% among men, and 6068.93% and − 5968.93% among women, respectively). The rates were 543.01% and − 443.01%, respectively, in urban areas and were 68.22% and 31.78%, respectively, in rural areas. The mortality rates according to demographic and non-demographic factors were − 495.93% and 595.93%, respectively (-1763.10% and − 1863.10% for men and − 270.56% and − 370.56% for women, respectively). These rates were − 930.33% and 1030.33%, respectively, in urban areas and were 101.48% and − 1.48%, respectively, in rural areas. Conclusions The overall standardized gallbladder cancer incidence and mortality rates in China are trending downward, but not sufficiently so. Proper living and eating habits should be encouraged while exploring the establishment of long-term, standardized gallbladder cancer screening programs.

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Section: Discussionsupporting

confidence: 90%

Gallbladder Cancer Incidence and Mortality Rate Trends in China: A National Population-based Cancer Registry

Zhang,

Xu,

Zhang

et al. 2024

Preprint

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“…Nutrients in dietary are metabolized by intestinal bacteria to multiple active metabolites which play a significant role in GBC development. Early GBC cases are associated with poor diet, including eating too few whole-grain foods, vegetables (radishes, green peppers and sweet potatoes) and fruits (mangoes, oranges, melons and papayas) and consuming too much mustard oil, red meat (beef and lamb) and tea ( Pandey and Shukla, 2002 ; La Vecchia et al., 2003 ; Mhatre et al., 2020 ; Nie et al., 2022 ).…”

Section: Bacteria In Gbc Pathogenesismentioning

confidence: 99%

The footprint of gut microbiota in gallbladder cancer: a mechanistic review

Liu,

Li,

Chen

et al. 2024

Front. Cell. Infect. Microbiol.

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Gallbladder cancer (GBC) is the most common malignant tumor of the biliary system with the worst prognosis. Even after radical surgery, the majority of patients with GBC have difficulty achieving a clinical cure. The risk of tumor recurrence remains more than 65%, and the overall 5-year survival rate is less than 5%. The gut microbiota refers to a variety of microorganisms living in the human intestine, including bacteria, viruses and fungi, which profoundly affect the host state of general health, disease and even cancer. Over the past few decades, substantial evidence has supported that gut microbiota plays a critical role in promoting the progression of GBC. In this review, we summarize the functions, molecular mechanisms and recent advances of the intestinal microbiota in GBC. We focus on the driving role of bacteria in pivotal pathways, such as virulence factors, metabolites derived from intestinal bacteria, chronic inflammatory responses and ecological niche remodeling. Additionally, we emphasize the high level of correlation between viruses and fungi, especially EBV and Candida spp., with GBC. In general, this review not only provides a solid theoretical basis for the close relationship between gut microbiota and GBC but also highlights more potential research directions for further research in the future.

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“…Так, соотношение женщины/мужчины варьирует от 1/1-2/1 в Восточной Азии до 5/1 и более в Испании и Колумбии [10]. В Китае среди пациентов с РЖП 73% составляют женщины [11]. В северной Индии, согласно данным ракового регистра, заболеваемость РЖП -4,5/100 000 у мужчин и 10,1/100 000 у женщин [12].…”

Section: заболеваемость и факторы риска рака желчного пузыряunclassified

Gallbladder Cancer: Incidence, Risk Factors, Diagnosis

Tonkikh,

Vasyutin,

Tsukanov

2024

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Aim. To analyze current data on the incidence, risk factors, diagnostic methods and prevention of gallbladder cancer (GBC). Key points. GBC is a malignant tumor arising from the epithelium of the gallbladder, characterized by local and vascular invasion, extensive regional lymphogenous and hematogenous metastasis. GBC is the most common malignant tumor of the biliary tract, characterized by high malignancy and low 5-year survival rate. In international recommendations, gastrointestinal tract is considered as a natural stage of the course of biliary pathology: dyskinesia — cholecystitis — cholelithiasis — GBC. Globally, the incidence of GBC varies significantly among different geographic regions, reaching 27 per 100,000 population in Chile. In Russia, according to the Federal State Statistics Service, the incidence of GBC in 2019 was 1.4 per 100 thousand among men, and 2.5 per 100 thousand among women. The incidence of GBC is associated with female gender and increasing age. In the pathogenesis of gallstones, decisive importance is attached to long-term inflammatory changes in the epithelium due to mechanical trauma to the mucous membrane of the gallbladder by stones and a probable increase in the proportion of secondary bile acids in the bile. In the diagnosis of GBC, the recommendations of the Japanese Society of Hepato-Biliary-Pancreatic Surgery, in the first step, particular importance is attached to ultrasound examination of the abdominal organs and biochemical blood test. For a more detailed study, computed tomography, magnetic resonance imaging, magnetic resonance cholangiopancreatography, endosonography, retrograde cholangiopancreatography, oral cholangioscopy and positron emission tomography are useful. Gallstone disease is one of the five most significant risk factors. The remaining 4 leading risk factors for GBC — ethnicity, genetic predisposition, lifestyle factors (excess weight) and biliary tract infections — are common risk factors for patients with cholelithiasis. The risk of developing GBC increases significantly in patients with stones larger than 2 cm and with the duration of the pathology for more than 5 years. Another significant risk factor for GBC is patients with gallbladder polyps, therefore the article presents the main recommendations of European associations for the management of patients with gallbladder polyps. Conclusion. GBC is currently considered as a possible and natural stage in the course of cholelithiasis. The risk of developing GBC increases significantly in patients with cholelithiasis and gallbladder polyps. Considering the above, diagnosis of possible complications in elderly patients with cholecystitis and gallstone disease should include a thorough clinical, laboratory and instrumental examination. Preventive measures for people with risk factors for GBC should include optimizing diet, weight loss, and, if possible, expanding the physical activity regime. Taking ursodeoxycholic acid preparations helps reduce the content of hydrophobic bile acids in bile and reduces the likelihood of complications of biliary pathology. Keywords: gallbladder cancer, cholelithiasis, gallbladder polyps, diagnosis, morbidity.

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Trend analysis and risk of gallbladder cancer mortality in China, 2013–2019

Cited by 10 publications

References 27 publications

Gallbladder Cancer Incidence and Mortality Rate Trends in China: A National Population-based Cancer Registry

Gallbladder Cancer Incidence and Mortality Rate Trends in China: A National Population-based Cancer Registry

The footprint of gut microbiota in gallbladder cancer: a mechanistic review

Gallbladder Cancer: Incidence, Risk Factors, Diagnosis

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