Trend Analysis of Gastric Cancer Incidence in Iran and Its Six Geographical Areas During 2000-2005

Haidari, Mohmmad; Nikbakht, Mohammad Reza; Pasdar, Yahya

doi:10.7314/apjcp.2012.13.7.3335

Cited by 25 publications

(19 citation statements)

References 32 publications

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“…The standardized incidence during the 15 years period showed great fluctuations but overall, there was a decreasing trend from 10.6/10 5 (95%CI: 8.2-13.9) in 1993 to 9.1/10 5 (95%CI: 7.4-11.1) in 2007 (Najafi et al, 2011) (Haidari et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Trend Analysis of Gastrointestinal Cancer Incidences in Guilan Province: Comparing Rates over 15 Years

Atrkarroushan

Kazemnejad²,

Ghanaei³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: Cancers of gastric and esophagus are the most frequent gastrointestinal (GI) tract cancers in Iran. This study aimed to analyze time trends of GI tract cancers in Guilan province by gender and age to provide solid scientific evidence for cancer prevention and control. Materials and Methods: The data were obtained from the Guilan Cancer Registry System and Guilan Provincial Health Center, over the 15 year period between 1997 and 2011. Crude incidence and age standardized (AS)incidence rates were calculated and annual percent change was estimated by Joinpoint software for long term trend analysis. Results: During the study period, 8,332 cases of GI malignances with a male to female ratio of 1:1.73 were registered in Guilan province. The AS rates for esophageal, gastric, colon and rectal cancers were 5.97, 14.5, 7.59 and 3.58 per 10 5 respectively. While the trend was declining and relatively constant for esophageal and gastric cancer, respectively, the incidence trend for colon and rectal cancers was of increase over the period of the study. Conclusions: The results indicated that the incidence of GI cancers was relatively low in Guilan province compared to neighboring provinces. An effective cancer control program including prevention measures, early detection and effective treatment needs to be implemented to reduce cancer morbidity and mortality.

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Section: Discussionmentioning

confidence: 99%

Trend Analysis of Gastrointestinal Cancer Incidences in Guilan Province: Comparing Rates over 15 Years

Atrkarroushan

Kazemnejad²,

Ghanaei³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…Reports from different parts of the world revealed very different results, but a higher incidence of gastric cancer in males compared to females is common (7).…”

Section: Introductionmentioning

confidence: 95%

HER-2/neu gene amplification in gastric adenocarcinoma and its relationship with clinical and pathological findings

Azarhoosh

Ebneghasem

Besharat

2017

J. Gastrointest. Oncol.

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Background: Amplification of the HER-2/neu oncogene influences the progression of gastric cancer, its prognosis, and therapy. A precise examination of HER-2/neu-amplified tumor tissue is essential for managing disease and prescribing the appropriate treatment. This study aimed to investigate the status of HER-2/neu gene in the gastric cancer samples and its relationship with clinical and pathological information. Methods: In this study on 80 paraffin-embedded tissue samples from patients with gastric adenocarcinoma [2006][2007][2008][2009][2010][2011], DNA was extracted to quantify the gene expression levels of HER-2 using a polymerase chain reaction (PCR) method. Data were statistically analyzed by chi-square test using SPSS16.0 software. Results: PCR results indicated that HER-2/neu gene amplifications occurred in 58 of the 80 samples (72.5%). HER-2/neu gene expression was not significantly related to age and sex, but the larger tumor size and the more advanced stage were significantly associated with HER-2/neu overexpression. Conclusions:The data show the HER-2/neu gene is more amplified in stage 4 of gastric cancer with a larger size of mass. Older age and male sex also appear to be more associated with HER-2/neu gene expression.

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“…Compared to China, there has been a more rapid decline in H pylori infection especially in young people in Japan (Lin et al, 2011). Iran is a high risk area for gastric cancer and incidence rates for gastric cancer are increasing, and incidence rates are higher in men than in women (Haidari et al, 2012). Similarly, studies from Pakistan have also demonstrated a rising incidence of gastric cancer, with a male preponderance and mean ages of 51.9 years and 48.8 in males and females respectively.…”

Section: Discussionmentioning

confidence: 92%

Gastrointestinal, Liver and Biliary Tract Pathology: A Histopathological and Epidemiological Perspective from Pakistan with a Review of the Literature

Ahmad

Arshad²,

Fatima³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Aim: To present an epidemiological and histological perspective of diseases of the gastrointestinal tract (including liver and biliary tract) at the Section of Histopathology, Department of Pathology, AKUH, Karachi, Pakistan. Materials and Methods: All consecutive endoscopic biopsies and resections between October 1 and December 31, 2012 were included. Results: A total of 2,323 cases were included. Carcinoma was overwhelmingly the commonest diagnosis on esophageal biopsies (69.1%); chronic helicobacter gastritis (45.6%) followed by adenocarcinoma (23.5%) were the commonest diagnoses on gastric biopsies; adenocarcinoma (27.3%) followed by ulcerative colitis (13.1%) were the commonest diagnoses on colonic biopsies; acute appendicitis (59.1%) was the commonest diagnosis on appendicectomy specimens; chronic viral hepatitis (44.8%) followed by hepatocellular carcinoma (23.4%) were the commonest diagnoses on liver biopsies; chronic cholecystitis was the commonest diagnosis (over 89%) on cholecystectomy specimens. Conclusions: Squamous cell carcinoma comprised 88.8% of esophageal cancers. About 67% were in the lower third and 56.5% were moderately differentiated; mean ages 49.8 years for females and 55.8 years for males; 66% cases were from South West Pakistan. Over 67% patients with gastric adenocarcinoma were males; mean ages 59 and 44 years in males and females respectively, about 74% gastric carcinomas were poorly differentiated; and 62.2% were located in the antropyloric region. About 63% patients with colorectal adenocarcinoma were males; mean ages 46.1 and 50.5 years for males and females respectively; tumor grade was moderately differentiated in 54%; over 80% were located in the left colon. In 21.2% appendicectomies, no acute inflammation was found. Acute appendicitis was most common in young people. Hepatitis C (66.3%) was more common than hepatitis B (33.7%); about 78% cases of hepatocellular carcinoma occurred in males; females comprised 76.7% patients with chronic cholecystitis; and 77.8% patients with gall bladder carcinoma. All resection specimens showed advanced cancers. Most cancers occurred after the age of 50 years.

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Trend Analysis of Gastric Cancer Incidence in Iran and Its Six Geographical Areas During 2000-2005

Cited by 25 publications

References 32 publications

Trend Analysis of Gastrointestinal Cancer Incidences in Guilan Province: Comparing Rates over 15 Years

Trend Analysis of Gastrointestinal Cancer Incidences in Guilan Province: Comparing Rates over 15 Years

HER-2/neu gene amplification in gastric adenocarcinoma and its relationship with clinical and pathological findings

Gastrointestinal, Liver and Biliary Tract Pathology: A Histopathological and Epidemiological Perspective from Pakistan with a Review of the Literature

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