Trend Change Analysis of postural balance in Parkinson`s disease discriminates between medication state

Abstract

Background Maintaining static balance is relevant and common in everyday life and it depends on a correct intersegmental coordination. A change or reduction in postural capacity has been linked to increased risk of falls. People with Parkinson's disease (PD) experience motor symptoms affecting the maintenance of a stable posture. The aim of the study is to understand the intersegmental changes in postural sway and to apply a trend change analysis to uncover different movement strategies between PD patients and healthy adults. Methods In total, 61 healthy participants, 40 young (YO), 21 old participants (OP), and 29 PD patients (13 during medication on, PDoff; 23 during medication on, PDon) were included. Participants stood quietly for 10 seconds. Inertial sensors at the head, sternum, and lumbar region collected tri-axial accelerations. Classical postural parameters and the trend change analysis (TCA) was applied on inertial measurement unit data of the head, sternum, and pelvis between groups. Objective This study aims to explore the potential application of TCA for the assessment of postural stability using IMUs, and secondly, to employ this analysis within the context of neurological diseases, specifically Parkinson's disease. Results Comparison of sensors locations revealed significant differences between head, sternum and pelvis for almost all parameters and cohorts. When comparing PDon and PDoff, the TCA revealed differences that were not seen by any other parameter. Conclusions While all parameters could differentiate between sensor locations, no group differences could be uncovered except for the TCA that allowed to distinguish between the PD on/off. The potential of the TCA to assess disease progression, response to treatment or even the prodromal PD phase should be explored in future studies. Trial registration: The research procedure was approved by the ethical committee of the Medical Faculty of Kiel University (D438/18). The study is registered in the German Clinical Trials Register (DRKS00022998).