Trend of CD4+ Cell Counts at Diagnosis and Initiation of Highly Active Antiretroviral Therapy (HAART): Korea HIV/AIDS Cohort Study, 1992-2015

Kim, Min Jung; Chang, Hyun Ha; Kim, Sang Il; Kim, Youn Jeong; Park, Dae Won; Kang, Chun; Kee, Mee Kyung; Choi, Jae Young; Kim, Soo Min; Choi, Bo Youl; Kim, June Myung; Choi, Jun Yong; Choi, Young Hwa; Lee, Jin Soo; Kim, Shin‐Woo; Hiv, Korea

doi:10.3947/ic.2017.49.2.101

Cited by 16 publications

(17 citation statements)

References 18 publications

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“…In this study, we observed that the overall median CD4 cell count at the time of diagnosis was 379 cell/mm3. This finding is higher when compared with other studies conducted in Asia, Korea, South America and Sub-Saharan Africa, which ranged from 67 cell/mm3 to 247 cell/mm3 (Kim et al,2017) (Kiertiburanakul et al,2014). The median CD4 cell count at diagnosis was lower than 350 cell/mm3 in 2012-2013 period and has increased to more than 350 cell/mm3 in 2014-2017 period.…”

Section: Discussioncontrasting

confidence: 54%

“…In Korea HIV/AIDS cohort study, 76% of newly infected HIV patients from 2010-2012 were diagnosed at CD4+ cell count lower than 350 cells/mm3 with overall median CD4+ cell count 195 cells/mm3. However, in the three most recent years (2013-2015), the number of patients with CD4+ cell counts of more than 350 cells/mm3 at the time of diagnosis has increased (Kim et al,2017). In the United Kingdom, 49% of newly infected HIV patients in 2011 were diagnosed at CD4+ cell count lower than 350 cells/mm 3 which was defined as late HIV diagnosis (V Delpech et al,2013).…”

Section: Discussionmentioning

confidence: 99%

“…Studies conducted in sub-Saharan Africa, South America and Asia reported the median CD4 count at start of therapy was 115 cells/mm3 [11] . All these studies concluded that CD4 cell count at HAART initiation was found to be very low (Kim et al, 2017) (Kiertiburanakul et al,2014) (ART-LINC). In Malaysia respectively, there is lack of published study regarding the trend of CD4 cell count.…”

Section: Consensusmentioning

confidence: 99%

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Trend of Cd4 Cell Count at Initiation of Highly Active Antiretroviral Therapy (Haart) in Klinik Kesihatan Seremban (Kks)

Zafirah

Gan

Choudhury

et al. 2018

IJALSR

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Background: CD4 T lymphocyte (CD4) is the most important marker that has been used in the management of HIV. The CD4 cell count provides information on the overall immune function of an HIV-infected patient. There is an overwhelming evidence that early initiation of HAART, at higher CD4 cell count will lead to virological and immunological success, prevent disease progression and reduces the social and economic costs of advanced HIV-related illness. We investigated the trend of CD4 cell count at initiation of HAART among HIV patients in KKS. Materials and Method: All registered HIV patients from year 2012 to 2017 were enrolled in this study. Data was collected retrospectively from patient's data base and clinic's registry using a standardized data collection form. The data was analyzed by using SPSS version 16.0 and presented with percentages, mean and median values. We also compared the CD4 cell count at HAART initiation with recommendation in Malaysian Consensus Guideline on Antiretroviral. Additionally, we investigated the possible factors that lead to late initiation of HAART. Results: Mean and median values of CD4 cell count at initiation of HAART were 411.03 cell/mm 3 and 314 cell/mm 3 respectively. There was an increasing trend of median CD4 cell count from 2014 until 2016 and in reducing trend in 2017. From 41 patients who were initiated on HAART, 68.3% (n=28) initiated HAART early while 31.7% (n=13) had late initiation. The late initiation of HAART was primarily due to late presenters. Conclusion: CD4 cell count at initiation of HAART in KKS was found to be high. Generally the practice of initiating HAART in KKS is in compliance to the Malaysian Consensus Guideline in ART. However, a number of patients with late initiation of HAART is of concern. We recommend a strategic interventions to increase earlier detection of HIV patients and earlier start of HAART at higher CD4 cell count to prevent HIV transmission and improve mortality and morbidity.

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Section: Discussioncontrasting

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Consensusmentioning

confidence: 99%

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Trend of Cd4 Cell Count at Initiation of Highly Active Antiretroviral Therapy (Haart) in Klinik Kesihatan Seremban (Kks)

Zafirah

Gan

Choudhury

et al. 2018

IJALSR

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“…In Korea, many patients already have a weakened immune state when first diagnosed with HIV infection, and thus, patients with opportunistic diseases at diagnosis are not uncommon. A previous study showed that the proportion of HIV-infected persons who have already progressed to a number of CD4 positive T cells below 200/μL at the time of diagnosis has been increasing up until the late 2000s [6], thus emphasizing the need for early diagnosis [7].…”

Section: Immune Status Of Hiv-infected Persons At Diagnosis In Koreamentioning

confidence: 99%

History of Acquired Immune Deficiency Syndrome in Korea

Kim

Choi

et al. 2020

Infect Chemother

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The first human immunodeficiency virus (HIV) infection was reported in Korea in 1985. The number of HIV-infected persons domestically increased in the 1990s showing epidemic indigenousization. Since then, the number of new infections gradually increased every year, and recently more than 1,000 newly infected cases were reported per year. A total of 12,522 infected individuals have been reported up to 2015, of which 2,020 died. The male to female ratio was 15.4:1, and 34.2% of them were under 30 years old. The infection route was homosexual and bisexual contact in 60.1% of cases and heterosexual contact in 34.6% of cases. Candidiasis, Pneumocystis pneumonia, tuberculosis were common as a AIDS (acquired immune deficiency syndrome)-defining illness. But with the introduction of antiretroviral therapy in the late 1990s, non-AIDS defining illnesses such as metabolic complications, cardiovascular diseases, bone diseases, and neuropsychiatric disorders such as neurocognitive dysfunction, depression, and anxiety are emerging as new health problems. The management policy switched its focus from regulating and monitoring of HIV-infected persons to ensuring access to treatment and promotion of voluntary HIV testing in high-risk groups. Also as the age of the infected persons increases, a need for various supports such as social rehabilitation, life counseling, and welfare has emerged.

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“…Therapy for human immunodeficiency virus (HIV)-infected patients has progressed remarkably since the introduction of antiretroviral therapy (ART). Furthermore, since the early start of effective ART, the incidence of opportunistic infections as well as the mortality rate in patients with HIV has decreased [ 1 - 3 ]. Liver disease is currently the major concern in HIV-infected patients coinfected with hepatitis B virus (HBV) or hepatitis C virus (HCV) [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Human Immunodeficiency Virus (HIV) and Hepatitis Virus Coinfection among HIV-Infected Korean Patients: The Korea HIV/AIDS Cohort Study

et al. 2017

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BackgroundDespite declines in mortality and morbidity rates of patients with human immunodeficiency virus (HIV) infection as the result of highly active antiretroviral therapy, liver diseases due to chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are a leading cause of death among HIV-infected patients. However, HIV and HBV or HCV coinfection is still poorly documented, and more information is needed to better understand the characteristics of HIV-infected patients in Korea.Materials and MethodsA cross-sectional study was performed to investigate clinical characteristics and prevalence of HBV and HCV infection in HIV patients enrolled in the Korea HIV/acquired immune deficiency syndrome (AIDS) cohort study from 17 institutions between December 2006 and July 2013.ResultsAmong the 1,218 HIV-infected participants, 541 were included in this study. The prevalence of HBV-HIV and HCV-HIV coinfection was 5.0% (27/541) and 1.7% (9/541), respectively. There was no patient who was positive for both HBs antigen and HCV antibody. In multivariate logistic regression analysis, HBV unvaccinated status was a significant risk factor for HBV-HIV coinfection (odds ratio = 4.95, 95% confidence interval = 1.43–17.13).ConclusionsHBV and HCV infection was more common in HIV-infected persons enrolled in the Korean HIV/AIDS cohort, than in the general population in Korea.

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Trend of CD4+ Cell Counts at Diagnosis and Initiation of Highly Active Antiretroviral Therapy (HAART): Korea HIV/AIDS Cohort Study, 1992-2015

Cited by 16 publications

References 18 publications

Trend of Cd4 Cell Count at Initiation of Highly Active Antiretroviral Therapy (Haart) in Klinik Kesihatan Seremban (Kks)

Trend of Cd4 Cell Count at Initiation of Highly Active Antiretroviral Therapy (Haart) in Klinik Kesihatan Seremban (Kks)

History of Acquired Immune Deficiency Syndrome in Korea

Human Immunodeficiency Virus (HIV) and Hepatitis Virus Coinfection among HIV-Infected Korean Patients: The Korea HIV/AIDS Cohort Study

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