Trend of subsequent epilepsy in children with recurrent febrile seizures: A retrospective matched cohort study

Tsai, Jeng Dau; Mou, Chih Hsin; Chang, Hsing Yi; Li, Tsai‐Chung; Tsai, Henry J.; Wei, Chang

doi:10.1016/j.seizure.2018.08.019

Cited by 13 publications

(10 citation statements)

References 26 publications

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“…A retrospective study in China shows that recurrent febrile seizures can increase the epilepsy cumulative incidence. 17 This supports the research data obtained that more patients had febrile seizures more than once. Another study conducted in Denmark also showed an increased risk of subsequent epilepsy in relation to the number of history of febrile seizures.…”

Section: Number Of History Of Febrile Seizuressupporting

confidence: 89%

Profile of History of Febrile Seizure in Patients With Epilepsy

Basyarahil

Islamiyah

Gunawan

2022

MNJ

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Background: Febrile seizure is convulsions with fever (temperature ³38°C) with no central nervous system infection that commonly found in children (6-60 months). Febrile seizures do not always mean the child has epilepsy. However, febrile seizures can be a possible long-term risk factor for epilepsy. Objective: The objective of this study is to know the profile of febrile seizure in patients with epilepsy. Methods: A retrospective descriptive study on 23 patients with epilepsy in the EEG Department of Neurology, Dr. Soetomo General Hospital, Surabaya, Indonesia in the period 2018-2019 based on inclusion and exclusion criteria. The total number of epilepsy patients is 849 patients, 216 of whom had a history of febrile seizure. Among 216 epilepsy patients who had a history of febrile seizures, 23 of them were qualified as the sample. The sampling technique used was total population sampling. The instrument of this research is the patients’ medical record. Data analysis is carried out descriptively. Results: The characteristics of the history of febrile seizures that found in patients with epilepsy are more patients are male, have the age of onset on less than 2 years old, have the body temperature more than 38.3°C, have the seizure duration less than 15 minutes, have focal seizures, have recurrent seizures in 24 hours, have a history of more than one febrile seizure, have accompanying neurological disorders, and have no family history of epilepsy. Conclusion: Febrile seizure is still becoming a concern because there is a possibility that it may develop into epilepsy. Even though, not all children who experience febrile seizure will generate epilepsy.

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Section: Number Of History Of Febrile Seizuressupporting

confidence: 89%

Profile of History of Febrile Seizure in Patients With Epilepsy

Basyarahil

Islamiyah

Gunawan

2022

MNJ

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“…The increased risk of epilepsy in this study is supported by a recent, large retrospective study that found an 18-fold increased incidence of epilepsy in children with recurrent febrile seizure admissions in Taiwan [5]. However, both studies have similar limitations by relying on hospital admissions and lacking classification between simple and complex febrile seizures.…”

supporting

confidence: 59%

Long-term Risks of Recurrent Febrile Seizures

Freedman¹,

Vidaurre²

2020

Pediatr Neurol Briefs

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“…In addition to the genetic predisposition and acute febrile illness, other factors that may be involved in the pathophysiology of SFS are the rate of rise of fever, respiratory alkalosis, vaccinations, peak body temperature, low birth weight, intrauterine growth retardation, and elevated cytokine levels during the acute illness. 34 The duration or type of febrile seizure (simple or complex) does not affect the recurrence risk, but prolonged febrile seizures may be associated with prolonged recurrences. 35 Although the risk of epilepsy in patients with SFS is low, some risk factors have been identified.…”

Section: Risk Factors For Recurrence Of Febrile Seizuresmentioning

confidence: 99%

“…The most important predictive risk factors for the development of epilepsy are developmental delay, abnormal neurological exam prior to the febrile seizure, history of complex febrile seizures or febrile status epilepticus, and a first degree relative with epilepsy. 5,9,34 The exact mechanism for development of epilepsy is complex and not fully elucidated. These risk factors may suggest a preexisting predisposition to develop epilepsy.…”

Section: Risk Factors For Recurrence Of Febrile Seizuresmentioning

confidence: 99%

Simple Febrile Seizures: A Benign Phenomena?

Andrade¹

2019

J Pediatr Epilepsy

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Febrile seizures are one of the most common neurological causes of visits to the emergency room. This article is a review of the current literature concerning the evaluation and treatment of children with febrile seizures. Longitudinal prospective studies such as the FEBSTAT study (consequences of prolonged febrile seizures in childhood) have contributed to elucidate the long-term outcome of patients with prolonged febrile seizures. Neurogenetic research also demonstrated the role of genetic mutations (mainly voltage-gated ion channels) in the etiology of febrile seizures. Most febrile seizures are self-limited events with low risk of injury or evolution into status epilepticus or sudden death. However, the use of rectal diazepam as acute abortive treatment for febrile seizures lasting 5 minutes or longer has gained acceptance as a first-line home intervention. Most patients with febrile seizures do not require extensive investigations, but the treatment involves a customized plan. Efforts should be directed to educate caregivers about prognosis and management of potential recurrences. In selected cases, appropriate use of preventive antiseizure medication may be a consideration.

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Trend of subsequent epilepsy in children with recurrent febrile seizures: A retrospective matched cohort study

Abstract: FS may increase the risk for subsequent epilepsy in children. Recurrent FS increased the cumulative incidence of epilepsy.

Cited by 13 publications

References 26 publications

Profile of History of Febrile Seizure in Patients With Epilepsy

Profile of History of Febrile Seizure in Patients With Epilepsy

Long-term Risks of Recurrent Febrile Seizures

Simple Febrile Seizures: A Benign Phenomena?

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