Trend to move from permanent metals to degradable, multifunctional polymer or metallic implants in the example of coronary stents

Reinthaler, Markus; Jung, F.; Landmesser, Ulf; Lendlein, Andreas

doi:10.1080/17434440.2016.1230013

Cited by 9 publications

(5 citation statements)

References 21 publications

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“…After arterial injury, platelets promptly adhere to the affected site and initiate the release of thromboxane A2. The glycoprotein (GP) IIb/IIIa complex engages with fibrinogen, facilitating platelet aggregation and activation [42]. Furthermore, activated platelets release many bioactive factors, among which the platelet-derived growth factor (PDGF) is prominent.…”

Section: Isr-definition Incidence and Pathophysiologymentioning

confidence: 99%

Intrastent Restenosis: A Comprehensive Review

Bajeu,

Niculescu,

Scafa-Udriște

et al. 2024

IJMS

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The primary objective of this paper is to delineate and elucidate the contemporary advancements, developments, and prevailing trajectories concerning intrastent restenosis (ISR). We aim to provide a thorough overview of the most recent developments in this area, covering various aspects such as pathophysiological insights, therapeutic approaches, and new strategies for tackling the complex challenges of ISR in modern clinical settings. The authors have undertaken a study to address a relatively new medical challenge, recognizing its significant impact on the morbidity and mortality of individuals with cardiovascular diseases. This effort is driven by the need to fully understand, analyze, and possibly improve the outcomes of this emerging medical issue within the cardiovascular disease field. We acknowledge its considerable clinical implications and the necessity for innovative methods to mitigate its effects on patient outcomes. Therefore, our emphasis was directed towards elucidating the principal facets of the condition’s prevalence, expounding upon the foundational mechanisms underscoring conspicuous restenosis, and delineating the risk factors relevant in shaping the contemporary landscape of diagnostic and therapeutic modalities. This thorough examination aims to provide a comprehensive understanding of the various dimensions of the condition, including epidemiological data, pathophysiological complexities, and clinical considerations critical for evaluating and enhancing current diagnostic and treatment approaches.

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Section: Isr-definition Incidence and Pathophysiologymentioning

confidence: 99%

Intrastent Restenosis: A Comprehensive Review

Bajeu,

Niculescu,

Scafa-Udriște

et al. 2024

IJMS

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“…In an observational study of 161 patients with recurrent angina after coronary stenting, platelet distribution width, an easily accessible marker of platelet activation, was an independent predictor of stent restenosis (Odd's ratio 1.2 [1.02-1.4], p = 0.025) [15]. Following arterial injury, platelets rapidly adhere and release thromboxane A2; the glycoprotein (GP) IIb/IIIa complex binds to fibrinogen, leading to platelet aggregation and activation [16]. In addition, activated platelets release multiple factors including platelet-derived growth factor (PDGF), which exerts a mitogen and chemotactic effect on SMCs and contributes to oxidative stress, one of the major determinants of the switch of vascular SMCs from a contractile to a synthetic phenotype [17].…”

Section: Cells Involved In the Pathophysiology Of In-stent Restenosismentioning

confidence: 99%

Restenosis after Coronary Stent Implantation: Cellular Mechanisms and Potential of Endothelial Progenitor Cells (A Short Guide for the Interventional Cardiologist)

Gori¹

2022

Cells

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Coronary stents are among the most common therapies worldwide. Despite significant improvements in the biocompatibility of these devices throughout the last decades, they are prone, in as many as 10–20% of cases, to short- or long-term failure. In-stent restenosis is a multifactorial process with a complex and incompletely understood pathophysiology in which inflammatory reactions are of central importance. This review provides a short overview for the clinician on the cellular types responsible for restenosis with a focus on the role of endothelial progenitor cells. The mechanisms of restenosis are described, along with the cell-based attempts made to prevent it. While the focus of this review is principally clinical, experimental evidence provides some insight into the potential implications for prevention and therapy of coronary stent restenosis.

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“…All three aspects will eventually influence the occurrence of thrombosis and inflammation because they are highly linked [ 17 , 103 , 104 ]. The success of the resulting therapeutic strategies will depend on the extent to which biological processes are modulated and how current medication influences this regulation [ 7 , 105 , 106 , 107 ]. Systemic studies addressing these questions are hardly done by only one laboratory and are thus rare.…”

Section: In Vitro Testingmentioning

confidence: 99%

Predicting the In Vivo Performance of Cardiovascular Biomaterials: Current Approaches In Vitro Evaluation of Blood-Biomaterial Interactions

Strohbach

Busch

2021

IJMS

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The therapeutic efficacy of a cardiovascular device after implantation is highly dependent on the host-initiated complement and coagulation cascade. Both can eventually trigger thrombosis and inflammation. Therefore, understanding these initial responses of the body is of great importance for newly developed biomaterials. Subtle modulation of the associated biological processes could optimize clinical outcomes. However, our failure to produce truly blood compatible materials may reflect our inability to properly understand the mechanisms of thrombosis and inflammation associated with biomaterials. In vitro models mimicking these processes provide valuable insights into the mechanisms of biomaterial-induced complement activation and coagulation. Here, we review (i) the influence of biomaterials on complement and coagulation cascades, (ii) the significance of complement-coagulation interactions for the clinical success of cardiovascular implants, (iii) the modulation of complement activation by surface modifications, and (iv) in vitro testing strategies.

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Trend to move from permanent metals to degradable, multifunctional polymer or metallic implants in the example of coronary stents

Cited by 9 publications

References 21 publications

Intrastent Restenosis: A Comprehensive Review

Intrastent Restenosis: A Comprehensive Review

Restenosis after Coronary Stent Implantation: Cellular Mechanisms and Potential of Endothelial Progenitor Cells (A Short Guide for the Interventional Cardiologist)

Predicting the In Vivo Performance of Cardiovascular Biomaterials: Current Approaches In Vitro Evaluation of Blood-Biomaterial Interactions

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