Trending Anti-Aging Peptides

Ferreira, Marta Salvador; Magalhães, Maria Catarina; Lobo, José Manuel Sousa; Almeida, Isabel F.

doi:10.3390/cosmetics7040091

Cited by 55 publications

(59 citation statements)

References 15 publications

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“…However, the fastest results can be obtained by undergoing a cosmetic procedure. 21 This clarifies that the optimal results obtained from the use of anti-aging products, if they are effective are slow.…”

Section: Discussionmentioning

confidence: 94%

Truths and myths about marketed anti-aging skin products: a systematic review

Barnawi

Barnawi²

2021

Int J Res Med Sci

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Aging of the skin naturally occurs with increasing age due to several factors involving the reduction of collagen, elastin and many other proteins which help maintain strength and integrity of the skin. Several strategies and treatments were developed to fight and slow down this unstoppable ongoing natural process, however, many of the widely available products may not be as efficient as advertised. The aim was to discuss and investigate the truths and myths about skin anti-aging products and strategies by reviewing the previous studies conducted on this subject. Google scholar database was explored to search for articles related to the current subjects starting from 2010 till 2021. The included searching terms were a combination of anti-aging strategies and efficacy, anti-aging products and myths, anti-aging products and usage of women and perception and attitude of women and anti-aging strategies. The inclusion criteria included original articles conducted on anti-aging products and strategies and full text articles. A total of 40 articles were obtained, only three articles were eligible for the inclusion criteria. The three studies included a total number of 192 participants. Some anti-aging products were found to improve skin health and improve the level of coarse and fine wrinkles and lines. However, their efficacy was limited and doesn't act as magic.

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Section: Discussionmentioning

confidence: 94%

Truths and myths about marketed anti-aging skin products: a systematic review

Barnawi

Barnawi²

2021

Int J Res Med Sci

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“…Progeline™ by LUCAS MEYER [300], a three-amino-acid biomimetic peptide (trifluoroacetyl tripeptide-2), was thus developed to improve wrinkles and sagging skin by modulating progerin [301,302]. More specifically, this active compound decreases progerin synthesis and accumulation, and inhibits metalloproteinases [297,303].…”

Section: Rethinking Skin Aging By Modulating Senescence Marker Proteins: the Case Of Progerinmentioning

confidence: 99%

“…Several companies, such as PHARMASPECIAL ® , GALENA ® , BIOTEC ® , LIPOTEC ® , and SILAB ® , are investing in technologically innovative signal-and neurotransmitter-inhibitor peptides particularly indicated as anti-aging ingredients for the formulation of skincare products [110,303].…”

Section: Biomimetic Peptidesmentioning

confidence: 99%

“…In this regard, however, it should be noted that the high efficacy compensates for the cost. In other words, for the formulation of cosmetic products, it is possible to employ these peptides in low amounts [303,343].…”

Section: Biomimetic Peptidesmentioning

confidence: 99%

“…Topical peptides can be classified as signals, carriers, enzyme inhibitors, or neurotransmitter inhibitors [110,301,303,335,346].…”

Section: Topical Peptides and Their Skin Permeabilitymentioning

confidence: 99%

See 2 more Smart Citations

Neurocosmetics in Skincare—The Fascinating World of Skin–Brain Connection: A Review to Explore Ingredients, Commercial Products for Skin Aging, and Cosmetic Regulation

et al. 2021

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The “modern” cosmetology industry is focusing on research devoted to discovering novel neurocosmetic functional ingredients that could improve the interactions between the skin and the nervous system. Many cosmetic companies have started to formulate neurocosmetic products that exhibit their activity on the cutaneous nervous system by affecting the skin’s neuromediators through different mechanisms of action. This review aims to clarify the definition of neurocosmetics, and to describe the features of some functional ingredients and products available on the market, with a look at the regulatory aspect. The attention is devoted to neurocosmetic ingredients for combating skin stress, explaining the stress pathways, which are also correlated with skin aging. “Neuro-relaxing” anti-aging ingredients derived from plant extracts and neurocosmetic strategies to combat inflammatory responses related to skin stress are presented. Afterwards, the molecular basis of sensitive skin and the suitable neurocosmetic ingredients to improve this problem are discussed. With the aim of presenting the major application of Botox-like ingredients as the first neurocosmetics on the market, skin aging is also introduced, and its theory is presented. To confirm the efficacy of the cosmetic products on the market, the concept of cosmetic claims is discussed.

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Enhanced Skin Permeation of Anti‐Aging Peptides Using Bioactive Ionic Liquids at Low Concentrations

Wang

Liu

et al. 2023

Adv Funct Materials

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Delaying aging is an eternal goal for humanity. Acetyl hexapeptide‐8 (AHP‐8) is an effective skin anti‐aging drug that locally interrupts the signal transmission of muscle contractions and promotes collagen production, thus smoothening wrinkles. However, its high molecular weight and strong hydrophilicity limit its skin permeation capacity. To solve this problem, an ionic liquid with excellent bioactivity, MAC, is synthesized from l‐malic acid and l‐carnitine and used as a permeation enhancer to improve the anti‐aging effects of AHP‐8. The ratio of MAC's components is optimized based on density functional theory calculations and cytotoxicity experiments. Low concentrations of MAC significantly increase AHP‐8 transdermal delivery, reaching a maximum at 5‐10 wt% MAC. The pro‐permeation mechanism of MAC is investigated using molecular dynamics simulations, and the penetration enhancement and anti‐aging performance of AHP‐8 are demonstrated by conducting cellular, animal, and clinical experiments. The results show that MAC/AHP‐8 outperforms AHP‐8 in terms of collagen and hyaluronic acid synthesis, anti‐inflammation, anti‐oxidation, and inhibition of muscle contraction, thus significantly reducing the number and area of wrinkles and increasing skin moisture and elasticity. This study presents MAC as a simple and efficient transdermal vehicle for the clinical application of AHP‐8.

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Trending Anti-Aging Peptides

Cited by 55 publications

References 15 publications

Truths and myths about marketed anti-aging skin products: a systematic review

Truths and myths about marketed anti-aging skin products: a systematic review

Neurocosmetics in Skincare—The Fascinating World of Skin–Brain Connection: A Review to Explore Ingredients, Commercial Products for Skin Aging, and Cosmetic Regulation

Enhanced Skin Permeation of Anti‐Aging Peptides Using Bioactive Ionic Liquids at Low Concentrations

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