This paper assessed the current and mid-century trends in rainfall and temperature over the Mono River watershed. It considered observation data for the period 1981-2010 and projection data from the regional climate model (RCM), REMO, for the period 2018-2050 under emission scenarios RCP4.5 and RCP8.5. Rainfall data were interpolated using ordinary kriging. Mann-Kendall, Pettitt and Standardized Normal Homogeneity (SNH) tests were used for trends and break-points detection. Rainfall interannual variability analysis was based on standardized precipitation index (SPI), whereas anomalies indices were considered for temperature. Results revealed that on an annual scale and all over the watershed, temperature and rainfall showed an increasing trend during the observation period. By 2050, both scenarios projected an increase in temperature compared to the baseline period 1981-2010, whereas annual rainfall will be characterized by high variabilities. Rainfall seasonal cycle is expected to change in the watershed: In the south, the second rainfall peak, which usually occurs in September, will be extended to October with a higher value. In the central and northern parts, rainfall regime is projected to be characterized by late onsets, a peak in September and lower precipitation until June and higher thereafter. The highest increase and decrease in monthly precipitation are expected in the northern part of the watershed. Therefore, identifying relevant adaptation strategies is recommended.Climate 2019, 7, 8 2 of 17 Furthermore, in tropical Africa a significant increase in temperature, about 0.15 • C per decade, was detected over the period 1979-2010 [5]. Consequently, high fatality rates are recorded in developing countries because of their high reliance on natural resources and their limited coping capacities [6]. Several authors highlighted that, since the 1970s, the number of natural disasters (flood, drought, windstorm, epidemic and famine) has been increasing in sub-Saharan Africa [7][8][9]. In 2012, central and western Africa were hit by severe floods which affected 1,538,242 people and caused 340 deaths as of September of that year. Moreover, flood events of 2010 have been recorded in West Africa as one of the most disastrous during the last decade. In 2010 only, Benin lost about USD 262 million [10], whereas Togo recorded about USD 43.934 million as damage and loss in the same year [11].Thus, there is a need to carry out future climate analysis in order to foresee potential hazards and ultimately to develop appropriate strategies to combat them. According to the fifth assessment report AR5, "global surface temperature change for the end of the 21st century is likely to exceed 1.5 • C relative to 1850-1900 for all RCP scenarios except RCP2.6" [12]. However, it is clear that climate-change impacts will be time and location specific [13]. Therefore, undertaking climate projection at regional and local level will contribute to more accurate and relevant actions towards human security.As in many other watersheds in the ...