Trends and Characteristics of Mortality Associated with Congenital Anomalies in Korean Children under 5 Years of Age

Abstract

Purpose: Studies have been conducted on the prevalence and infant mortality rate of congenital anomalies; however, studies on child mortality are rare. Therefore, we evaluated the characteristics of deaths associated with congenital anomalies among children born in Korea who died within 5 years of age.Methods: Birth-to-death cohort linked data of children under the age of 5 years from 2010 to 2013, and statistical data on the cause of death by age from 1999 to 2019, both provided by the Korea National Statistical Office's Microdata Integrated Service, were retrospectively investigated. We investigated the trends and characteristics of mortality associated with congenital anomalies.Results: Among 1,858,945 children, 6,510 children who died were under 5 years of age, and among them, 1,229 deaths were associated with congenital anomalies, while 5,281 deaths were due to other causes. Deaths associated with congenital anomalies accounted for 18.9% of all deaths. When comparing congenital anomalies by systems, anomalies of the cardiovascular system (52.6%) were the most common. The mortality rate associated with congenital anomalies and those of other causes showed similar declining trends in 21 years.Conclusion: The mortality rate of congenital anomalies during the first 5 years of life did not increase differently from the prevalence of congenital anomalies but rather decreased. Deaths associated with congenital anomalies accounted for 20.5% of all infant deaths and 12.1% of child deaths, since the major causes of death in infants and children are slightly different, continuous and careful monitoring is required.

Perinatal Prognostic Factors for Congenital Diaphragmatic Hernia: A Korean Single-Center Study

“…Congenital diaphragmatic hernia (CDH) is a rare form of congenital disease with a frequency of 1 in 2,000 to 5,000 births; however, CDH mortality is high [1][2][3][4][5] . Kim et al 6) reported that CDH is the most frequent cause of death among infants aged <1 year (1.31%) between 2010 and 2013. Death of CDH patients is not due to the absence of the diaphragm itself, but due to secondary conditions, including pulmonary hypoplasia and pulmonary hypertension caused by infiltration of abdominal organs into the thoracic cavity due to the absence of the diaphragm.…”