Trends and Comparisons of Blood Pressure and Fasting Plasma Glucose in Patients with Hypertension, Diabetes, and Comorbidity: 4-Year Follow-Up Data

Xu, Luxinyi; Wen, Xiaotong; Yang, Ying; Cui, Dan

doi:10.2147/rmhp.s385815

Cited by 3 publications

(1 citation statement)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hypertension is a major threat to global health affecting millions of families. [1][2][3] It has become a major influencing factor in the risk of cardiovascular disease, therapeutic effect of complications, and a leading cause of serious adverse events including death worldwide. [4][5][6][7] Hypertension has been recently reported to have a prevalence of 2.5% among children in Ghana.…”

Section: Introductionmentioning

confidence: 99%

Real-World Prescribing Patterns for Hypertensive Children in China from 2018 to 2021: A Cross-Sectional Multicenter Study

Qi¹,

Wang²,

Kan³

et al. 2023

RMHP

View full text Add to dashboard Cite

Background: Pediatric hypertension become an early marker of cardiovascular diseases, but their antihypertensive drug use patterns are rarely known. Purpose: To investigate the epidemiological characteristics of pediatric hypertension and the use of antihypertensive drugs in the real world in China. Methods: In this study, the demographic, diagnosis, and medication prescription data including the antihypertensive drug types and comorbidities, were analyzed. The antihypertensive drugs use were evaluated according to the Chinese guidelines for hypertension. Results: 1301 prescriptions (number of visits) containing 1880 antihypertensive medical orders were collected. The average number of antihypertensive drugs per prescription was 1.45 (±0.75). The patients aged 16 to 18 (70.18%) accounted for the highest proportion. Kidney diseases (33.28%) were the most common comorbidities. Calcium channel blocker (CCB), angiotensin II receptor blocker (ARB), and β receptor blocker (BB) were the most used antihypertensive drugs. The most frequent monotherapy was CCB, while that of two and three drugs combination were ARB+CCB and ARB+BB+CCB, respectively. Metoprolol (11.44%), nifedipine (10.64%), amlodipine (10.59%), valsartan (6.12%) were the most commonly used antihypertensive drugs. The utilization rate of fixed compound preparations was 7.34%. However, the percentage of recommended antihypertensive drugs was just 14.20%, while the recommended drug combination was 84.93% according to the guidelines. Conclusion:For the first time ever we reported the antihypertensive prescription analysis in children in a large area of China. Our data provided new insights into the epidemiological characteristics and drug use in hypertensive children. We found that the guidelines for medication management in hypertensive children were not routinely followed. The wide use of antihypertensive drugs in children and those with weak clinical evidence raised concerns regarding its rational use. The findings could lead to more effective management of hypertension in children.

show abstract

Section: Introductionmentioning

confidence: 99%

Real-World Prescribing Patterns for Hypertensive Children in China from 2018 to 2021: A Cross-Sectional Multicenter Study

Qi¹,

Wang²,

Kan³

et al. 2023

RMHP

View full text Add to dashboard Cite

show abstract

A Framework for the Analysis of Comorbid Conditions Using Intelligent Extraction of Multiple Fluid Biomarkers

Jadhav

Selvaraju

Sathian

et al. 2023

J. Mech. Med. Biol.

View full text Add to dashboard Cite

Fluid biomarkers extracted from many types of body fluids provide significant information that serve as indicators of the underlying physiological and pathological conditions of the human body. Analysis of multiple fluid biomarkers could help improve the early identification and progression of comorbid conditions to enhance the diagnostic accuracy, which can help in developing patient-specific treatment plans. In this work, an attempt has been made to differentiate the co-occurrence of diabetes, hypertension and cardiovascular disease (comorbid conditions) from non-comorbid using multiple fluid biomarkers. Fluid biomarkers are obtained from a public dataset under comorbid ([Formula: see text]) and non-comorbid ([Formula: see text]) conditions. Five features, such as serum creatinine, serum sodium, platelet count, creatine phosphokinase and ejection fraction, are extracted for further analysis. Machine learning algorithms namely, [Formula: see text]-nearest neighbor and linear discriminant analysis (LDA) are used to classify comorbid and non-comorbid conditions. The results show an increase in platelet count in comorbid subjects. This feature also exhibits significant difference ([Formula: see text]) between both the conditions. This study also uses the random undersampling technique to reduce bias associated with data imbalance. LDA classifier yields a maximum accuracy of 54.30% in classifying these two conditions. Further study can be carried out to improve the accuracy and might be helpful in clinical practice for prediction of comorbid conditions.

show abstract

Association of healthy lifestyle score with control of hypertension among treated and untreated hypertensive patients: a large cross-sectional study

Dong,

Zhou,

Lin

et al. 2024

PeerJ

View full text Add to dashboard Cite

Background Hypertension stands as the leading single contributor to the worldwide burden of mortality and disability. Limited evidence exists regarding the association between the combined healthy lifestyle score (HLS) and hypertension control in both treated and untreated hypertensive individuals. Therefore, we aimed to investigate the association between HLS and hypertension control among adults with treated and untreated hypertension. Methods This cross-sectional study, including 311,994 hypertension patients, was conducted in Guangzhou using data from the National Basic Public Health Services Projects in China. The HLS was defined based on five low-risk lifestyle factors: healthy dietary habits, active physical activity, normal body mass index, never smoking, and no alcohol consumption. Controlled blood pressure was defined as systolic blood pressure <140 mmHg and diastolic blood pressure <90 mmHg. A multivariable logistic regression model was used to assess the association between HLS and hypertension control after adjusting for various confounders. Results The HLS demonstrated an inverse association with hypertension control among hypertensive patients. In comparison to the low HLS group (scored 0–2), the adjusted odds ratios (95% confidence intervals) for hypertension were 0.76 (0.74, 0.78), 0.59 (0.57, 0.60), and 0.48 (0.46, 0.49) for the HLS groups scoring 3, 4, and 5, respectively (Ptrend < 0.001). Notably, an interaction was observed between HLS and antihypertensive medication in relation to hypertension control (Pinteraction < 0.001). When comparing the highest HLS (scored 5) with the lowest HLS (scored 0–2), adjusted odds ratios (95% confidence intervals) were 0.50 (0.48, 0.52, Ptrend < 0.001) among individuals who self-reported using antihypertensive medication and 0.41 (0.38, 0.44, Ptrend < 0.001) among those not using such medication. Hypertensive patients adhering to a healthy lifestyle without medication exhibited better blood pressure management than those using medication while following a healthy lifestyle. Conclusion HLS was associated with a reduced risk of uncontrolled blood pressure.

show abstract

Trends and Comparisons of Blood Pressure and Fasting Plasma Glucose in Patients with Hypertension, Diabetes, and Comorbidity: 4-Year Follow-Up Data

Cited by 3 publications

References 39 publications

Real-World Prescribing Patterns for Hypertensive Children in China from 2018 to 2021: A Cross-Sectional Multicenter Study

Real-World Prescribing Patterns for Hypertensive Children in China from 2018 to 2021: A Cross-Sectional Multicenter Study

A Framework for the Analysis of Comorbid Conditions Using Intelligent Extraction of Multiple Fluid Biomarkers

Association of healthy lifestyle score with control of hypertension among treated and untreated hypertensive patients: a large cross-sectional study

Contact Info

Product

Resources

About