Trends and determining factors associated with adherence to antiretroviral therapy (ART) in Cameroon: a systematic review and analysis of the CAMPS trial

Mbuagbaw, Lawrence; Thabane, Lehana; Ongolo‐Zogo, Pierre; Yondo, David; Noorduyn, Stephen G.; Śmieja, Marek; Dolovich, Lisa

doi:10.1186/1742-6405-9-37

Cited by 28 publications

(34 citation statements)

References 40 publications

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“…Similar to other studies conducted in Ethiopia [15, 34, 35], and in Africa [32, 36] the level of CD4 count during initiation of treatment have independent effect for adherence status. Non-adherence was higher among patients with a CD4 count <350 cells/mm 3 compared to their counterparts.…”

Section: Discussionsupporting

confidence: 84%

Determinants to antiretroviral treatment non-adherence among adult HIV/AIDS patients in northern Ethiopia

et al. 2017

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BackgroundAdhering 95% and above of antiretroviral therapy reduces the rate of disease progression and death among people’s living human immunodeficiency virus. Though manifold factors have reported as determinant factors of antiretroviral therapy adherence status, perhaps determinants of non-adherence differ up on the activities of patients in the study setting.MethodsAn institution based unmatched case–control study was conducted in Aksum town. Individuals who had a 6-month follow-up with complete individual information were included in the study. Document review and interviewer based techniques were used to collect the data. Binary logistic regression analysis was used to identify the determinant factors of non-adherence.ResultsA total of 411 (137 cases and 274 control) study participants were included in the study. The majority of them were male in sex. Having 2 years and above duration on ART [AOR = 7, 95% CI (2.2, 22.6)], history of adverse effect [AOR = 6.9, 95% CI (1.4, 32.9)], substance use [AOR = 5.3, 95% CI (1.4, 20.0)], living with parents [AOR = 3.4, 95% CI (1.2, 10.3)], having depression symptom [AOR = 3.3, 95% CI (1.4, 7.5)], <350 cells/mm3 cluster of differentiation 4 count [AOR = 3.2, 95% CI (1.8, 5.8)] and low dietary diversity [AOR = 2, 95% CI (1.1, 3.7)] were found significant determinants of non-adherence to antiretroviral drug.ConclusionProgram, social and individual related factors showed a statistically significant associated with non-adherence to antiretroviral therapy. Managing lifestyle by developing self-efficacy of individuals and treating related threat to improve adherence status of antiretroviral therapy is recommended in this study.

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Section: Discussionsupporting

confidence: 84%

Determinants to antiretroviral treatment non-adherence among adult HIV/AIDS patients in northern Ethiopia

et al. 2017

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“…A study in Botswana showed that adherence was higher when cost was not an obstacle and poor patients were able to achieve excellent rates of adherence when they had access to free laboratory monitoring and subsidized ART [26]. Similar findings was also made in a study in Cameroon where it was observed that although ART drugs were provided free of charge, other related services were still funded by out-of-pocket payments hence a cause of non-adherence [27]. …”

Section: Treatment Of Co-infectionssupporting

confidence: 58%

Therapy and Health System-Related Factors Influencing Adherence to ART Treatment among HIV/AIDS Patients in Embu Teaching and Referral Hospital Comprehensive Care Clinic

Mugoh¹,

Kabiru²,

Mwaniki³

2016

AJNS

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Abstract:Adherence to antiretroviral therapy is a major predictor of the survival of individuals living with HIV/AIDS. Appropriate use of antiretroviral (ARV's) has improved the health of many human immunodeficiency virus (HIV) positive individuals. The effectiveness of HIV treatment depends on sustenance of high levels of adherence to ARV; however, ARV regimens are often complicated and can be affected by varying dosing schedules, failing to have proper dietary requirements and patients developing adverse effects. The objective of this study was to determine therapy and health system related factors influencing adherence to Anti-retroviral drugs among adult HIV/ AIDS patients in Embu County Teaching and Referral Hospital Comprehensive Care Clinic. The study applied cross sectional descriptive design with stratified random sampling used to obtain relative proportion of male and female adult respondents in the sample population. 332 HIV positive patients were chosen from a total of 1694 patients who were active in ART for more than one year. A semi-structured interview schedules was used to obtain patients view on various dimension or ART services at the facility. ART adherence was at 48.2%. There was significant association between adherence to ART treatment and the type of drug a respondent was in with AZT, ddl, NFV having the highest proportion of sub-optimal adherence to treatment while respondents on D4T, 3TC, NVP had the lowest proportion of sub-optimal adherence to treatment. Convenience of the facilities for people with chronic ailments and waiting time at the facilities were reported to be good (73.0%) and excellent (75.3%) respectively.

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“…On the other hand participants with a higher duration on ART were not willing to participate. Patient who have received ART for long periods may have developed other adherence enhancing strategies and would not be willing to include yet another [ 39 ]. They may also have developed hard-to-change medication taking habits.…”

Section: Discussionmentioning

confidence: 99%

“…They may also have developed hard-to-change medication taking habits. However, adherence to long term medication is known to wane over time and such patients require additional support [ 5 , 39 ]. For such patients it is necessary to build on the other benefits to be reaped from such a project.…”

Section: Discussionmentioning

confidence: 99%

A framework for community ownership of a text messaging programme to improve adherence to antiretroviral therapy and client-provider communication: a mixed methods study

Mbuagbaw

Bonono-Momnougui

Thabane

et al. 2014

BMC Health Serv Res

Self Cite

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BackgroundMobile phone text messaging has been shown to improve adherence to antiretroviral therapy and to improve communication between patients and health care workers. It is unclear which strategies are most appropriate for scaling up text messaging programmes. We sought to investigate acceptability and readiness for ownership (community members designing, sending and receiving text messages) of a text message programme among a community of clients living with human immunodeficiency virus (HIV) in Yaoundé, Cameroon and to develop a framework for implementation.MethodsWe used the mixed-methods sequential exploratory design. In the qualitative strand we conducted 7 focus group discussions (57 participants) to elicit themes related to acceptability and readiness. In the quantitative strand we explored the generalizability of these themes in a survey of 420 clients. Qualitative and quantitative data were merged to generate meta-inferences.ResultsBoth qualitative and quantitative strands showed high levels of acceptability and readiness despite low rates of participation in other community-led projects. In the qualitative strand, compared to the quantitative strand, more potential service users were willing to pay for a text messaging service, preferred participation of health personnel in managing the project and preferred that the project be based in the hospital rather than in the community. Some of the limitations identified to implementing a community-owned project were lack of management skills in the community, financial, technical and literacy challenges. Participants who were willing to pay were more likely to find the project acceptable and expressed positive feelings about community readiness to own a text messaging project.ConclusionCommunity ownership of a text messaging programme is acceptable to the community of clients at the Yaoundé Central Hospital. Our framework for implementation includes components for community members who take on roles as services users (demonstrating clear benefits, allowing a trial period and ensuring high levels of confidentiality) or service providers (training in project management and securing sustainable funding). Such a project can be evaluated using participation rate, clinical outcomes, satisfaction with the service, cost and feedback from users.Electronic supplementary materialThe online version of this article (doi:10.1186/1472-6963-14-441) contains supplementary material, which is available to authorized users.

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Trends and determining factors associated with adherence to antiretroviral therapy (ART) in Cameroon: a systematic review and analysis of the CAMPS trial

Cited by 28 publications

References 40 publications

Determinants to antiretroviral treatment non-adherence among adult HIV/AIDS patients in northern Ethiopia

Determinants to antiretroviral treatment non-adherence among adult HIV/AIDS patients in northern Ethiopia

Therapy and Health System-Related Factors Influencing Adherence to ART Treatment among HIV/AIDS Patients in Embu Teaching and Referral Hospital Comprehensive Care Clinic

A framework for community ownership of a text messaging programme to improve adherence to antiretroviral therapy and client-provider communication: a mixed methods study

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