Trends and Factors Associated with Initial and Recurrent Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA) Skin and Soft-Tissue Infections among HIV-Infected Persons

Vyas, Kartavya J.; Shadyab, Aladdin H.; Lin, Chii‐Dean; Crum-Cianflone, Nancy F.

doi:10.1177/2325957412473780

Cited by 26 publications

(32 citation statements)

References 23 publications

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“…The risk factors indicated as predisposing factors for the susceptibility of people with HIV/AIDS to MRSA are: CD4+T lymphocyte count below 500 cell/mm 3 , HIV viral load of 400 copies/ml or above, use of injectable drugs, old age, prior hospitalization and invasive procedures (7,12) . Based on that, most participants of this study presented most risk factors indicated as predisposing factors for colonization by MRSA in this investigated population.…”

Section: Discussionmentioning

confidence: 99%

Staphylococcus aureus and the oxacillin sensitivity profile in hospitalized people with HIV/AIDS

Pio

Reinato

Lopes

et al. 2016

Rev. esc. enferm. USP

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Objective Analyze nasal colonization by oxacillin-sensitive and oxacillin-resistant Staphylococcus aureus in people with HIV/AIDS (PWHA) at days 1 and7 of hospitalization. METHOD A prospective observational study conducted in a hospital in the countryside of the state of São Paulo. Nasal swab samples were collected and analyzed through microbiological identification, at days 1 and 7 of hospitalization of PWHA, between August 2011 and January 2014. Data were analyzed via IBM SPSS(r), version 20.0. RESULTS Nasal secretion samples were collected from 187 (50.1%) PWHA at days 1 and 7 of hospitalization. Of these, Staphylococcus aureus was identified in 64 (34.2%) PWHA. CONCLUSION At day 1 of hospitalization, 27 PWHA were identified with Staphylococcus aureus; 27 PWHA presented colonization by Staphylococcus aureus at days 1 and 7, and 10 PWHA only at day 7. Of 64 PWHA colonized by Staphylococcus aureus, the susceptibility profile of isolated Staphylococcus aureus was oxacillin-resistant in 25 PWHA.

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Section: Discussionmentioning

confidence: 99%

Staphylococcus aureus and the oxacillin sensitivity profile in hospitalized people with HIV/AIDS

Pio

Reinato

Lopes

et al. 2016

Rev. esc. enferm. USP

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“…In further support of a role for T cells in defense against S. aureus SSTI, patients with poorly controlled HIV (as assessed by low CD4+ T cell counts and high viral loads) frequently have recurrent SSTI [36], although there are conflicting data on the importance of CD4+ counts as a predictor of SSTI risk [37]. Patients with atopic dermatitis are also susceptible to S. aureus SSTI, which may be partly due to increased levels of Th2 cytokines and subsequent STAT6 expression, that may increase susceptibility to Hla-induced keratinocyte death [38].…”

Section: Text Of Reviewmentioning

confidence: 99%

Host factors that contribute to recurrent staphylococcal skin infection

Montgomery

David²,

Daum³

2015

Current Opinion in Infectious Diseases

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Purpose of review Staphylococcus aureus is the most common cause of skin and soft tissue infections (SSTI) in the United States and elsewhere. Recurrent infections occur frequently in patients with S. aureus SSTI, underscoring the need to better understand the nature of protective immunity against these infections. Here, we review recent findings concerning the host factors that predispose to S. aureus SSTI. Recent findings Recurrent infections occur in nearly half of all patients with S. aureus SSTI. Epidemiologic and environmental factors, such as exposure to health care, age, household contacts with S. aureus SSTI, and contaminated household fomites are associated with recurrence. The majority of the population has evidence of antistaphylococcal antibodies, but whether these are protective remains enigmatic. In contrast, recent clinical and experimental findings clearly highlight the critical roles of innate and T cell-mediated immunity in defense against these infections. S. aureus interferes with innate and adaptive immunity by a number of recently elucidated mechanisms. Summary Recurrent S. aureus SSTIs are common, suggesting incomplete or absent protective immunity among these patients. Our understanding of protective immunity against recurrent infections is incomplete, and further basic and translational investigation is urgently needed to design strategies to prevent and treat these infections.

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“…Vyas et al evaluated initial and recurrent infections with MRSA retrospectively in a cohort of mainly HIV-infected men, with 80 % on ART [17]. Eight percent developed a primary infection; associated risk factors included a CD4 count <500 cells/ml, HIV RNA levels >400 copies/ml, and injection drug use.…”

Section: Bacterial Infectionsmentioning

confidence: 99%

Cutaneous Manifestations of Human Immunodeficiency Virus: a Clinical Update

Altman

Vanness

Westergaard

2015

Curr Infect Dis Rep

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Dermatologic diseases are common in the HIV-infected population. Many of the cutaneous diseases are not unique to this group, but the presentation can be more severe. Although the introduction of antiretroviral therapy has been followed by a decline in many of the skin diseases associated with HIV, drug reactions and other non-infectious skin conditions have increased. This article reviews the current spectrum of HIV-associated skin conditions, focusing on common complaints, infections, drug-associated toxicity and malignancies.

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Trends and Factors Associated with Initial and Recurrent Methicillin-Resistant Staphylococcus aureus (MRSA) Skin and Soft-Tissue Infections among HIV-Infected Persons

Abstract: HIV control and avoidance of IDU may be useful in reducing rates of MRSA SSTIs among HIV-infected persons.

Cited by 26 publications

References 23 publications

Staphylococcus aureus and the oxacillin sensitivity profile in hospitalized people with HIV/AIDS

Staphylococcus aureus and the oxacillin sensitivity profile in hospitalized people with HIV/AIDS

Host factors that contribute to recurrent staphylococcal skin infection

Cutaneous Manifestations of Human Immunodeficiency Virus: a Clinical Update

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