Trends and hassles in the microbial production of lactic acid from lignocellulosic biomass

Nwamba, Marknoah Chinenye; Sun, Fubao; Mukasekuru, Marie Rose; Song, Guojie; Harindintwali, Jean Damascene; Ajeje, Samaila Boyi; Sun, Haiyan

doi:10.1016/j.eti.2020.101337

Cited by 66 publications

(36 citation statements)

References 142 publications

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“…During LA production, the end-product LA lowers the pH of the medium, and thus impedes LA-producers' growth. Neutral agents, such as calcium hydroxide (Ca(OH) 2 ), sodium hydroxide (NaOH), and ammonia, are needed for LA production, which increases the costs of downstream process [3]. There have been various trials to develop the strains with tolerance to acid pH and improve the capacity to produce LA at high yields and productivity.…”

Section: L-lactic Acid Producing Strainsmentioning

confidence: 99%

“…Pre-treatment of lignocellulosic feedstocks are critical for high-quality LA production. LA production from lignocellulosic biomass is quite challenging with an associated high pre-treatment costs [3].…”

Section: Lignocellulosic Biomassmentioning

confidence: 99%

“…Because D-lactic acid cannot be metabolized by the human body, studies on D-lactic acid fermentation are lim-ited [2]. Recently, the increasing use of PLA has led to a surge in the demand for D-lactic acid [3]. A few wild-type strains, such as L. delbrueckii, B. laevolacticus, L. coryniformis, Corynebacterium glutamicum, and L. bulgaricus, have been reported to be homofermentative D-lactic acid producers.…”

Section: D-lactic Acid Biosynthesismentioning

confidence: 99%

“…At an estimated 10% replacement of fossil-fuel-based plastics, the overall demand for PLA is envisioned to reach 30 million tons per year. As the precursor of PLA, the demand for LA is estimated to reach 1960 kilotons by 2025 [3]. There are three forms of LA: L-lactic acid, D-lactic acid and racemic mixtures (DL-lactic acid) [4].…”

Section: Introductionmentioning

confidence: 99%

“…Microbial production of LA has more benefits, including cheap raw materials and mild production conditions. At present, microbial fermentation is the main industrial route for LA production [3]. On the other hand, as the most widely applied use of LA and one of the most promising biodegradable plastics, PLA possesses much more outstanding advantages compared to other polymers, since it has biodegradability, biocompatibility, clarity, and superior barrier properties, along with suitable material properties for general performance plastics [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

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A Review of the Recent Developments in the Bioproduction of Polylactic Acid and Its Precursors Optically Pure Lactic Acids

Huang

Xue

et al. 2021

Molecules

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Lactic acid (LA) is an important organic acid with broad industrial applications. Considered as an environmentally friendly alternative to petroleum-based plastic with a wide range of applications, polylactic acid has generated a great deal of interest and therefore the demand for optically pure l- or d-lactic acid has increased accordingly. Microbial fermentation is the industrial route for LA production. LA bacteria and certain genetic engineering bacteria are widely used for LA production. Although some fungi, such as Saccharomyces cerevisiae, are not natural LA producers, they have recently received increased attention for LA production because of their acid tolerance. The main challenge for LA bioproduction is the high cost of substrates. The development of LA production from cost-effective biomasses is a potential solution to reduce the cost of LA production. This review examined and discussed recent progress in optically pure l-lactic acid and optically pure d-lactic acid fermentation. The utilization of inexpensive substrates is also focused on. Additionally, for PLA production, a complete biological process by one-step fermentation from renewable resources is also currently being developed by metabolically engineered bacteria. We also summarize the strategies and procedures for metabolically engineering microorganisms producing PLA. In addition, there exists some challenges to efficiently produce PLA, therefore strategies to overcome these challenges through metabolic engineering combined with enzyme engineering are also discussed.

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Section: L-lactic Acid Producing Strainsmentioning

confidence: 99%

Section: Lignocellulosic Biomassmentioning

confidence: 99%

Section: D-lactic Acid Biosynthesismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Review of the Recent Developments in the Bioproduction of Polylactic Acid and Its Precursors Optically Pure Lactic Acids

Huang

Xue

et al. 2021

Molecules

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A review on lactic acid production via microbial fermentation from biowaste: insights on scaling up to industrial process

Haris,

Salleh,

Nolasco‐Hipolito

et al. 2024

Biofuels Bioprod Bioref

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Lactic acid (LA), the starting material for polylactic acid, is currently in high demand owing to rising bioplastic production. Large‐scale production of LA typically uses a first‐generation feedstock, namely food‐grade sugars, owing to the absence of contaminants and ease of processing. However, it is not ethically correct to grow crops exclusively for LA production as the available land, water and resources should be utilized for food. Utilizing biowaste as a feedstock, which does not compete with the supply of the food chain, is a more responsible strategy. This review intends to address the most critical aspect of recent advances in laboratory‐ and pilot‐scale LA production that utilizes biowaste as the substrate. Based on the review, the biowastes used for LA fermentation can be categorized into four main groups: starchy materials, lignocellulosic materials, food and dairy wastes. A flowchart that summarizes the process of developing a pilot scale LA production is proposed. It covers essential parameters to be considered, such as the substrate, fermentation process and inoculum. The future insights concerning LA production are critically addressed at the end of this review.

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Cyclic l‐lactide synthesis from lignocellulose biomass by biorefining with complete inhibitor removal and highly simultaneous sugars assimilation

Jia

Qiu

et al. 2022

Biotech & Bioengineering

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Cyclic chiral lactide is the monomer chemical for polymerization of high molecular weight polylactic acid (PLA). The synthesis of cyclic l‐lactide starts from poly‐condensation of l‐lactic acid to a low molecular weight prepolymer and then depolymerized to cyclic l‐lactide. Lignocellulose biomass is the most promising carbohydrate feedstock for lactic acid production, but the synthesis of cyclic l‐lactide from l‐lactic acid produced from lignocellulose has so far not been successful. The major barriers are the impurities of residual sugars and inhibitors in the crude cellulosic l‐lactic acid product. Here we show a successful cyclic l‐lactide synthesis from cellulosic l‐lactic acid by lignocellulose biorefining with complete inhibitor removal and coordinated sugars assimilation. The removal of inhibitors from lignocellulose pretreatment was accomplished by biodetoxification using a unique fungus Amorphotheca resinae ZN1. The nonglucose sugars were completely and simultaneously assimilated at the same rate with glucose by the engineered l‐lactic acid bacterium Pediococcus acidilactici. The l‐lactic acid production from wheat straw was comparable to that from corn starch with high optical pure (99.6%), high l‐lactic acid titer (129.4 g/L), minor residual total sugars (~2.2 g/L), and inhibitors free. The cyclic l‐lactide was successfully synthesized from the regularly purified l‐lactic acid and verified by detailed characterizations. This study paves the technical foundation of carbon‐neutral production of biodegradable PLA from lignocellulose biomass.

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Trends and hassles in the microbial production of lactic acid from lignocellulosic biomass

Cited by 66 publications

References 142 publications

A Review of the Recent Developments in the Bioproduction of Polylactic Acid and Its Precursors Optically Pure Lactic Acids

A Review of the Recent Developments in the Bioproduction of Polylactic Acid and Its Precursors Optically Pure Lactic Acids

A review on lactic acid production via microbial fermentation from biowaste: insights on scaling up to industrial process

Cyclic l‐lactide synthesis from lignocellulose biomass by biorefining with complete inhibitor removal and highly simultaneous sugars assimilation

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