Trends and implementation of preemptive pharmacogenomic testing

Silva, Patrick J.; Ramos, Kenneth S.

doi:10.1016/b978-0-12-824010-6.00053-8

Comprehensive Precision Medicine 2024

DOI: 10.1016/b978-0-12-824010-6.00053-8

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Trends and implementation of preemptive pharmacogenomic testing

Patrick J. Silva¹,

Kenneth S. Ramos²

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2024

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Cited by 1 publication

References 129 publications

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Health equity innovation in precision medicine: data stewardship and agency to expand representation in clinicogenomics

Silva,

Rahimzadeh,

Powell

et al. 2024

Health Res Policy Sys

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Most forms of clinical research examine a very minute cross section of the patient journey. Much of the knowledge and evidence base driving current genomic medicine practice entails blind spots arising from underrepresentation and lack of research participation in clinicogenomic databases. The flaws are perpetuated in AI models and clinical practice guidelines that reflect the lack of diversity in data being used. Participation in clinical research and biobanks is impeded in many populations due to a variety of factors that include knowledge, trust, healthcare access, administrative barriers, and technology gaps. A recent symposium brought industry, clinical, and research participants in clinicogenomics to discuss practical challenges and potential for new data sharing models that are patient centric and federated in nature and can address health disparities that might be perpetuated by lack of diversity in clinicogenomic research, biobanks, and datasets. Clinical data governance was recognized as a multiagent problem, and governance practices need to be more patient centric to address most barriers. Digital tools that preserve privacy, document provenance, and enable the management of data as intellectual property have great promise. Policy updates realigning and rationalizing clinical data governance practices are warranted.

show abstract

Health equity innovation in precision medicine: data stewardship and agency to expand representation in clinicogenomics

Silva,

Rahimzadeh,

Powell

et al. 2024

Health Res Policy Sys

View full text Add to dashboard Cite

show abstract

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Trends and implementation of preemptive pharmacogenomic testing

Cited by 1 publication

References 129 publications

Health equity innovation in precision medicine: data stewardship and agency to expand representation in clinicogenomics

Health equity innovation in precision medicine: data stewardship and agency to expand representation in clinicogenomics

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