Trends and Opportunities in Enzyme Biosensors Coupled to Metal-Organic Frameworks (MOFs): An Advanced Bibliometric Analysis

Abstract

The unique properties of metal-organic frameworks (MOFs) such as their large surface area and high porosity have attracted considerable attention in recent decades. The MOFs are a promising class of materials for developing highly efficient biosensors due to these same properties. This bibliometric analysis focused on the use of MOFs as enzyme-coupled materials in biosensor construction and aimed to provide a comprehensive overview of the research field by analyzing a collected database. The analysis included identifying the countries that have published the most, the most prominent applications, and trends for future directions in the field. The study used three databases with different numbers of documents, differentiated by research areas, with refinements made to the search as needed. The results suggest that MOF-derived biosensors are a growing field, with the Republic of China emerging as a significant contributor to research in this area. The study also used computational processing of trend analysis and geocoding to reveal these findings.

Evolving sustainable energy technologies and assessments through global research networks: advancing the role of blue hydrogen for a cleaner future

“…35–37 The objective is to identify patterns and trends in the scientific literature and map the main contributions and authors in a field of study. 38–40…”

One-Pot Synthesis of 1,3,5-Trisubstitued Pyrazoles via Immobilized Thermomyces lanuginosus Lipase (TLL) on a Metal–Organic Framework

“…One of these methods is enzyme immobilization. , Porous substrate is one of the most widely used platforms for enzyme immobilization. Silica, organic microparticles, and metal–organic frameworks (MOFs) are an example of these platforms. − MOFs consist of metal cores and organic ligands, and due to their high active surface, adjustable cavities, and resistance to high temperature and chemicals, they are a suitable substrate for enzyme immobilization. , …”

“…29−31 MOFs consist of metal cores and organic ligands, and due to their high active surface, adjustable cavities, and resistance to high temperature and chemicals, they are a suitable substrate for enzyme immobilization. 32,33 In recent years, enzymes have been used as a powerful method in synthesis of organic compounds. 34 Enzyme promiscuity in chemical reactions has been one of the fascinating debates about enzymes.…”

“… 29 − 31 MOFs consist of metal cores and organic ligands, and due to their high active surface, adjustable cavities, and resistance to high temperature and chemicals, they are a suitable substrate for enzyme immobilization. 32 , 33 …”

Ratiometric Lanthanide Metal‐Organic Frameworks (MOFs) for Smartphone‐Assisted Visual Detection of Food Contaminants and Water: A Review

“…[31][32][33][34][35][36][37][38] MOFs have received great attention in the last ten years because of their large surface areas, high porosity, tunable structural flexibility, excellent thermal stability, and the strong interactions formed by metals and ligands. [39][40][41] MOFs have found extensive use across various fields, [42][43][44] including separating and storing gases, [45][46][47][48] drug delivery, [49][50][51] catalysis, [25,52] and chemical sensors. [53][54][55] The utilization of optical MOFs has gained considerable scientific interest, primarily due to the presence of aromatic sub-units that emit light, leading to the discovery of numerous photoluminescent MOFs.…”