Trends and perspectives in bio- and eco-friendly sustainable nanomaterial delivery systems through biological barriers

Kim, Seongchan; Oh, Taegon; Lee, Hyojin; Nam, Jwa‐Min

doi:10.1039/d2qm00039c

Cited by 8 publications

(6 citation statements)

References 238 publications

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“…[5,6] Nanotechnology is a multidisciplinary field that combines techniques from various disciplines such as chemistry, engineering, physics, and biological sciences. [7,8] Nanoparticles (NPs) are defined as particles with dimensions ranging from 1-100 nm and nanotechnology encompasses their synthesis, development, and diverse applications. [9,10] Ongoing studies in sustainability and green chemistry have led to the development of innovative techniques that leverage biological agents, including bacteria, fungi, actinomycetes, yeast, and algae, for NPs synthesis.…”

Section: Introductionmentioning

confidence: 99%

Bio‐fabrication of Zinc oxide nanoparticles using Strobilanthes cordifolia: Characterization and evaluation of antioxidant, anti‐cholinergic, anti‐inflammatory and wound healing activities

Kirubakaran,

Selvam,

Subramanian Shivakumar

et al. 2024

ChemistrySelect

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Strobilanthes cordifolia has emerged as a promising material in traditional medicine. In this study, we have made an attempt to synthesize zinc oxide nanoparticles derived from S. cordifolia leaf. The team employed a wide range of techniques including UV, FT‐IR, XRD, FE‐SEM with EDAX, HR‐TEM with SAED, DLS, Zeta potential, BET and PZC analysis to thoroughly examine the properties of the NPs. FTIR analysis provided evidence of various functional groups within the NPs. XRD analysis demonstrated the crystal nature and phase purity of the NPs. SEM analysis showcased the spherical shape of the particles, while TEM revealed their rod‐like shape with sizes averaging at approximately 10 nm. DLS analysis indicated the average particle size, and the high zeta potential value confirmed the stability and BET analysis deciphered the specific surface area of the biosynthesized NPs. The NPs confirmed strong antioxidant properties with DPPH, ABTS, and hydroxyl radicals. Enzyme studies confirmed good anti‐cholinergic activity and anti‐inflammatory efficacy, highlighting their potential therapeutic benefits. The NPs demonstrated promising wound healing properties. Overall, this research study sheds light on the medicinal aspects of zinc oxide nanoparticles from S. cordifolia leaf extract and it offers exciting prospects for future exploration and development in this field.

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Section: Introductionmentioning

confidence: 99%

Bio‐fabrication of Zinc oxide nanoparticles using Strobilanthes cordifolia: Characterization and evaluation of antioxidant, anti‐cholinergic, anti‐inflammatory and wound healing activities

Kirubakaran,

Selvam,

Subramanian Shivakumar

et al. 2024

ChemistrySelect

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“…For example, trace amounts of fluorine species, due to their strong reactivity, can degrade device components such as gate oxides [32][33][34] or metal electrodes, [35] leading to the device failure over longterm use. More importantly, for their sustainable use on biological interfaces, [36][37][38] fluorinated MXenes can raise safety concerns because the transudation of fluoride ions can be toxic to living organisms. The toxicity concerns of the fluorinated MXenes remain controversial; some reports have supported the biocompatibility of HF-synthesized MXenes, [39][40][41][42][43][44][45] whereas others reported their cytotoxicity as a function of concentration.…”

Section: Introductionmentioning

confidence: 99%

Biocompatible and Oxidation‐Resistant Ti₃C₂T_x MXene with Halogen‐Free Surface Terminations

et al. 2023

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Surface chemistry influences not only physicochemical properties but also safety and applications of MXene nanomaterials. Fluorinated Ti3C2Tx MXene, synthesized using conventional HF‐based etchants, raises concerns regarding harmful effects on electronics and toxicity to living organisms. In this study, well‐delaminated halogen‐free Ti3C2Tx flakes are synthesized using NaOH‐based etching solution. The transversal surface plasmon mode of halogen‐free Ti3C2Tx MXene (833 nm) confirmed red‐shift compared to conventional Ti3C2Tx (752 nm), and the halogen‐free Ti3C2Tx MXene has a different density of state by the high proportion of –O and –OH terminations. The synthesized halogen‐free Ti3C2Tx exhibits a lower water contact angle (34.5°) and work function (3.6 eV) than those of fluorinated Ti3C2Tx (49.8° and 4.14 eV, respectively). The synthesized halogen‐free Ti3C2Tx exhibits high biocompatibility with the living cells, as evidenced by no noticeable cytotoxicity, even at very high concentrations (2000 µg mL⁻1), at which fluorinated Ti3C2Tx caused ≈50% reduction in cell viability upon its oxidation. Additionally, the oxidation stability of halogen‐free Ti3C2Tx is enhanced unexpectedly, which cumulatively provides a good rationale for pursuing the halogen‐free routes for synthesizing MXene materials for their uses in biomedical and therapeutic applications.

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“…The modern sustainable development trend in area of biologically active polymers and materials based on them is the technology that allows creating effective systems for drugs and active substances transdermal delivery into the human body [1].…”

Section: Introductionmentioning

confidence: 99%

Design and researching of biologically active polymeric hydrogel transdermal materials modified by humic acid

Lebedeva,

Cherkashina,

Tykhomyrova

et al. 2023

IOP Conf. Ser.: Earth Environ. Sci.

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Biologically active polymer hydrogel transdermal materials based on gelatin, sodium alginate, modified by humic acids, were designed and researched. Literature review was carried out and it was proved that humic acids using is perspective for the functional effect on the biologically active polymer hydrogel transdermal properties. It has been found that effective processes for receiving biologically active polymer hydrogel transdermal materials based on gelatin, hydroxypropyl cellulose and sodium alginate can be carried out in different humic acids concentration while achieving an effective increase in hydrogel polymers structuring processes. It can be seen efficiently increasing biologically active polymeric hydrogel transdermal materials based on gelatin and sodium alginate conditional viscosity and the specific electrical conductivity with an increase of humic acids content: from 114 to 135 sec and from 2350 to 2850 mkS/cm, respectively. Humic acids modification in biologically active polymeric hydrogel transdermal materials based on gelatin and sodium alginate caused structure formation with high density, and resistance and with larger agglomerates in hydrogels. It was found that the gelatin-based biopolymer hydrogels modification by humic acids makes it possible to receive biologically active polymeric hydrogel transdermal materials with higher swelling degree. It is shown that the application of new biologically active polymeric hydrogel transdermal materials based on gelatin and sodium alginate modified by humic acids allows improving the skin moisture-lipid balance. From the initial values of 34-36% moisture and 8-10 skin fat, they increase to 58-66% and 52-60%. So, designed polymer hydrogel based on gelatin, sodium alginate, modified by humic acids, are transdermal materials with good properties.

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Trends and perspectives in bio- and eco-friendly sustainable nanomaterial delivery systems through biological barriers

Abstract: Many polices, including the European Green Deal, have been released to enhance global economic sustainability. Such policies require new materials to be sustainable, cost-effective, and safe for the fabrication of...

Cited by 8 publications

References 238 publications

Bio‐fabrication of Zinc oxide nanoparticles using Strobilanthes cordifolia: Characterization and evaluation of antioxidant, anti‐cholinergic, anti‐inflammatory and wound healing activities

Bio‐fabrication of Zinc oxide nanoparticles using Strobilanthes cordifolia: Characterization and evaluation of antioxidant, anti‐cholinergic, anti‐inflammatory and wound healing activities

Biocompatible and Oxidation‐Resistant Ti₃C₂T_x MXene with Halogen‐Free Surface Terminations

Design and researching of biologically active polymeric hydrogel transdermal materials modified by humic acid

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Trends and perspectives in bio- and eco-friendly sustainable nanomaterial delivery systems through biological barriers

Abstract: Many polices, including the European Green Deal, have been released to enhance global economic sustainability. Such policies require new materials to be sustainable, cost-effective, and safe for the fabrication of...

Cited by 8 publications

References 238 publications

Bio‐fabrication of Zinc oxide nanoparticles using Strobilanthes cordifolia: Characterization and evaluation of antioxidant, anti‐cholinergic, anti‐inflammatory and wound healing activities

Bio‐fabrication of Zinc oxide nanoparticles using Strobilanthes cordifolia: Characterization and evaluation of antioxidant, anti‐cholinergic, anti‐inflammatory and wound healing activities

Biocompatible and Oxidation‐Resistant Ti3C2Tx MXene with Halogen‐Free Surface Terminations

Design and researching of biologically active polymeric hydrogel transdermal materials modified by humic acid

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Product

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Biocompatible and Oxidation‐Resistant Ti₃C₂T_x MXene with Halogen‐Free Surface Terminations