2014
DOI: 10.1128/aac.02239-13
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Trends and Seasonal Variation in Outpatient Antibiotic Prescription Rates in the United States, 2006 to 2010

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Cited by 142 publications
(139 citation statements)
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“…7,26,31,54,57 The b-lactams, predominantly penicillins, cephalosporins, and carbapenems, as well as their derivatives, share a four-membered ring that irreversibly inhibits the transpeptidases involved in bacterial peptidoglycan cross-linking, leading to cell lysis. The most common mechanism of b-lactam resistance is found in the b-lactamase enzymes, 21 which hydrolyze the b-lactam ring, rendering the drug inactive.…”
mentioning
confidence: 99%
“…7,26,31,54,57 The b-lactams, predominantly penicillins, cephalosporins, and carbapenems, as well as their derivatives, share a four-membered ring that irreversibly inhibits the transpeptidases involved in bacterial peptidoglycan cross-linking, leading to cell lysis. The most common mechanism of b-lactam resistance is found in the b-lactamase enzymes, 21 which hydrolyze the b-lactam ring, rendering the drug inactive.…”
mentioning
confidence: 99%
“…Approximately 12 × 10 6 kg of antimicrobial drugs are administered to food animals annually in the United States; roughly 61% of these are medically relevant. Higher resistance frequencies in winter/spring (12.2%) than summer/ fall (7.5%) could be attributed to variation in prescription rates by season (10).…”
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confidence: 99%
“…Seasonal variation in antibiotic use has been associated with short-term lowering of resistance rates in the United States (7) and Israel (8); moreover, low seasonal variation has been related to appropriate-use profiles in Europe (9,10). Furthermore, it has been suggested that a better understanding of seasonal variation of antibiotic prescribing can be useful in the design of interventions to reduce inappropriate use of antibiotics (11).…”
mentioning
confidence: 99%