Trends and variation in the management of oesophagogastric cancer patients: a population-based survey

Lyratzopoulos, Georgios; Barbiere, Josephine; Gajperia, Chetna; Rhodes, Michael; Greenberg, David; Wright, Karen A.

doi:10.1186/1472-6963-9-231

Cited by 11 publications

(12 citation statements)

References 27 publications

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“…We therefore believe that the observed reduction in surgery use most probably reflects improved patient selection because of better staging, by endoscopic ultrasound, and/or CT and functional imaging (PET) scanning 4. Similar decreasing trends in surgery use have been reported for upper gastrointestinal cancers 5. The proportion of patients with ‘unspecified’ lung cancer who were treated by surgery was very small and could not explain the observed decrease in use of surgery.…”

Section: Discussionmentioning

confidence: 53%

Population-based trends in use of surgery for non-small cell lung cancer in a UK region, 1995-2006

McMahon

Barbiere

Greenberg

et al. 2011

Thorax

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Objective To assess time trends in use of surgery in patients with non-small cell lung cancer (NSCLC) in a UK region. Methods Cancer registration data for patients diagnosed with NSCLC between 1995 and 2006 in the East of England were analysed. Rates of surgery use for different age, gender, diagnosis period, tumour subtype and deprivation quintile groups were examined. Results The analysis included 18 767 patients with NSCLC. During the study period, 13% of patients were treated by surgery. Use of surgery decreased over time from 15% in 1995e1997 to 11% in 2004e2006 (p¼0.022). Initial socioeconomic differences in surgery use narrowed significantly over time (p¼0.028) and became non-apparent at the end of the study period. Conclusions Use of surgery in patients with NSCLC decreased during the study period, possibly reflecting increasing quality of preoperative staging processes. Initial socioeconomic inequalities in surgery use became undetectable at the end of the study period. The findings provide baseline information to support comparisons with patterns of clinical management in more recent years.

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Section: Discussionmentioning

confidence: 53%

Population-based trends in use of surgery for non-small cell lung cancer in a UK region, 1995-2006

McMahon

Barbiere

Greenberg

et al. 2011

Thorax

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“…Most studies reported no significant association between pre- or postdiagnosis alcohol consumption and OS (1–10). However, some studies found a protective effect of alcohol (11–16) and one showed an adverse effect (28). We excluded six of these studies from the meta-analysis as follows.…”

Section: Resultsmentioning

confidence: 99%

“…The local area Index of Multiple Deprivation was used as a proxy for socioeconomic status (SES; ref. 28). Age at diagnosis, vital status, and data on tumor characteristics were obtained through the ECRIC.…”

Section: Methodsmentioning

confidence: 99%

Alcohol Consumption and Survival after a Breast Cancer Diagnosis: A Literature-Based Meta-analysis and Collaborative Analysis of Data for 29,239 Cases

Ali

Schmidt

Bolla

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Evidence for an association of alcohol consumption with prognosis after a diagnosis of breast cancer has been inconsistent. We have reviewed and summarized the published evidence and evaluated the association using individual patient data from multiple case cohorts. Methods A MEDLINE search to identify studies published up to January 2013 was performed. We combined published estimates of survival time for “moderate drinkers” versus nondrinkers. An analysis of individual participant data using Cox regression was carried out using data from 11 case cohorts. Results We identified 11 published studies suitable for inclusion in the meta-analysis. Moderate post-diagnosis alcohol consumption was not associated with overall survival [HR, 0.95; 95% confidence interval (CI), 0.85–1.05], but there was some evidence of better survival associated with prediagnosis consumption (HR, 0.80; 95% CI, 0.73–0.88). Individual data on alcohol consumption for 29,239 cases with 4,839 deaths were available from the 11 case cohorts, all of which had data on estrogen receptor (ER) status. For women with ER-positive disease, there was little evidence that pre- or postdiagnosis alcohol consumption is associated with breast cancer–specific mortality, with some evidence of a negative association with all-cause mortality. On the basis of a single study, moderate postdiagnosis alcohol intake was associated with a small reduction in breast cancer–specific mortality for women with ER-negative disease. There was no association with prediagnosis intake for women with ER-negative disease. Conclusion There was little evidence that pre- or post-diagnosis alcohol consumption is associated with breast cancer–specific mortality for women with ER-positive disease. There was weak evidence that moderate post-diagnosis alcohol intake is associated with a small reduction in breast cancer–specific mortality in ER-negative disease. Impact Considering the totality of the evidence, moderate postdiagnosis alcohol consumption is unlikely to have a major adverse effect on the survival of women with breast cancer.

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“…Our findings echo those of Lyratzopoulos et al . () in respect of chemotherapy treatment for AC. That we were able to better characterise patients in terms of stage and co‐morbidity gives further credence to our findings and the possibility of a social gradient in respect of total resource use.…”

Section: Discussionmentioning

confidence: 99%

“…Recent work in the UK also points to differences in the treatment experience of oesophageal cancer patients related to measures of patient deprivation (Lyratzopoulos et al . ). More deprived patients were found to be less likely to receive curative surgery and, in particular, chemotherapy than those from less deprived areas.…”

Section: Introductionmentioning

confidence: 97%

Description and predictors of hospital costs of oesophageal cancer during the first year following diagnosis in Northern Ireland

Agus¹,

Kinnear

O’Neill

et al. 2013

Eur J Cancer Care (Engl)

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The cost-effectiveness of novel interventions in the treatment of cancer is well researched; however, relatively little attention is paid to the cost of many aspects of routine care. Oesophageal cancer is the ninth most common cancer in the UK and sixth most common cause of cancer death. It usually presents late and has a poor prognosis. The hospital costs incurred by oesophageal cancer patients diagnosed in Northern Ireland in 2005 (n = 198) were determined by review of medical records. The average cost of hospital care per patient in the 12 months from presentation was £7847. Variations in total hospital costs by age at diagnosis, gender, cancer stage, histological type, mortality at 1 year, co-morbidity count and socio-economic status were analysed using multiple regression analyses. Higher costs were associated with earlier stages of cancer and cancer stage remained a significant predictor of costs after controlling for cancer type, patient age and mortality at 1 year. Thus, although early detection of cancer usually improves survival, this would mean increased costs in the first year. Deprivation achieved borderline significance with those from more deprived areas having lower resource consumption relative to the more affluent.

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Trends and variation in the management of oesophagogastric cancer patients: a population-based survey

Cited by 11 publications

References 27 publications

Population-based trends in use of surgery for non-small cell lung cancer in a UK region, 1995-2006

Population-based trends in use of surgery for non-small cell lung cancer in a UK region, 1995-2006

Alcohol Consumption and Survival after a Breast Cancer Diagnosis: A Literature-Based Meta-analysis and Collaborative Analysis of Data for 29,239 Cases

Description and predictors of hospital costs of oesophageal cancer during the first year following diagnosis in Northern Ireland

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