Background: Accidents pose a serious threat to health and economy in Egypt. Objectives: To identify and analyze the epidemiological factors associated with different types of accidents among adult males in Upper Egypt. Methods: A sample of 500 Egyptian males 20-28 years of age attending for health care at Quena University Hospital (QUH) or affiliated health institutions in South Egyptian governorates of Luxor and Red Sea was studied. The demographic, socioeconomic, and habitual data, as well as health status, medical history, and history of engagement into accidents for the recruits all were evaluated. Results: Accidents occurrences accounted up to 23/500 (4.6%) of the studied group. Road traffic accidents (RTAs) represented the highest percentage (30.4%), followed by street fights (21.7%) and animal bites (13.1%). Occupational accidents, electrical injuries, and near-drowning, all were equally encountered (8.7%), whereas falls and burns were least prevalent (4.3% each). Drug abuse, manual work, obesity, and having epilepsy were significant risk factors for accident injuries (