Trends in Biomedical Nanotechnology Programs Worldwide

Malsch, Ineke; Morrison, Mark

doi:10.1201/9781420028621.ch1

Cited by 4 publications

(3 citation statements)

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“…[1][2][3][4][5][6] Moving from the macro-to the micro-and nano-scale provides several advantages: less sample required, greater sensitivity because of increased contact area between analyte solution and device surface, and the possibility of developing portable, or even implantable devices through miniaturization.…”

Section: Introductionmentioning

confidence: 99%

DNA Binding to the Silica Surface

et al. 2015

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We investigate the DNA-silica binding mechanism using molecular dynamics simulations. This system is of technological importance, and also of interest to explore how negatively charged DNA can bind to a silica surface, which is also negatively charged at pH values above its isoelectric point near pH 3. We find that the two major binding mechanisms are attractive interactions between DNA phosphate and surface silanol groups and hydrophobic bonding between DNA base and silica hydrophobic region. Umbrella sampling and the weighted histogram analysis method (WHAM) are used to calculate the free energy surface for detachment of DNA from a binding configuration to a location far from the silica surface. Several factors explain why single-stranded DNA (ssDNA) has been observed to be more strongly attracted to silica than double-stranded (dsDNA): (1) ssDNA is more flexible and therefore able to maximize the number of binding interactions. (2) ssDNA has free unpaired bases to form hydrophobic attachment to silica while dsDNA has to break hydrogen bonds with base partners to get free bases. (3) The linear charge density of dsDNA is twice that of ssDNA. We devise a procedure to approximate the atomic forces between biomolecules and amorphous silica to enable large-scale biomolecule-silica simulations as reported here.

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Section: Introductionmentioning

confidence: 99%

DNA Binding to the Silica Surface

et al. 2015

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“…3 However, parasitic effects that can substantially alter signals and electrical properties must be identified. Water molecules are one of them because of their presence in ambient atmosphere, and their strong affinity with many surfaces.…”

Section: -Introductionmentioning

confidence: 99%

Role of Hydration on the Electronic Transport through Molecular Junctions on Silicon

et al. 2012

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ABSTRACT. Molecular electronics is a fascinating area of research with the ability to tune device properties by a chemical tailoring of organic molecules. However, molecular electronics devices often suffer from dispersion and lack of reproducibility of their electrical performances. Here, we show that water molecules introduced during the fabrication process or coming from the environment can strongly modify the electrical transport properties of molecular junctions made on hydrogen-terminated silicon.We report an increase in conductance by up to three orders of magnitude, as well as an induced asymmetry in the current-voltage curves. These observations are correlated with a specific signature of the dielectric response of the monolayer at low frequency. In addition, a random telegraph signal is observed for these junctions with macroscopic area. Electrochemical charge transfer reaction between the semiconductor channel and H + /H2 redox couple is proposed as the underlying phenomenon.Annealing the samples at 150°C is an efficient way to suppress these water-related effects. This study paves the way to a better control of molecular devices and has potential implications when these monolayers are used as hydrophobic layers or incorporated in chemical sensors.

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“…Potential applications of molecular nanonetworks include, but are not limited to, intelligent drug delivery systems, diagnostic and therapeutic antiviral activities, and prosthetic implants techniques [8], [9], [10].…”

Section: Introductionmentioning

confidence: 99%

Simulation-based evaluation of the diffusion-based physical channel in molecular nanonetworks

Garralda

Llátser

Cabellos‐Aparicio

et al. 2011

2011 IEEE Conference on Computer Communications Workshops (INFOCOM WKSHPS)

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Abstract-Nanonetworking is an emerging field of research, where nanotechnology and communication engineering are applied on a common ground. Molecular Communication (MC) is a bio-inspired paradigm, where Nanonetworks, i.e., the interconnection of devices at the nanoscale, are based on the exchange of molecules. Amongst others, diffusion-based MC is expected to be suitable for covering short distances (nm-µm). In this work, we explore the main characteristics of diffusion-based MC through the use of N3Sim, a physical simulation framework for MC. N3Sim allows for the simulation of the physics underlying the diffusion of molecules for different scenarios. Through the N3Sim results, the Linear Time Invariant (LTI) property is proven to be a valid assumption for the free diffusion-based MC scenario. Moreover, diffusion-based noise is observed and evaluated with reference to already proposed stochastic models. The optimal pulse shape for diffusion-based MC is provided as a result of simulations. Two different pulse-based coding techniques are also compared through N3Sim in terms of available bandwidth and energy consumption for communication.

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Trends in Biomedical Nanotechnology Programs Worldwide

Cited by 4 publications

References 0 publications

DNA Binding to the Silica Surface

DNA Binding to the Silica Surface

Role of Hydration on the Electronic Transport through Molecular Junctions on Silicon

Simulation-based evaluation of the diffusion-based physical channel in molecular nanonetworks

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