Trends in cancer mortality in Mexico, 1981–2007

Bosetti, Cristina; Rodrı́guez, Teresa; Chatenoud, Liliane; Bertuccio, Paola; Levi, Fabio; Negri, Eva; Vecchia, Carlo La

doi:10.1097/cej.0b013e32834653c9

Cited by 44 publications

(33 citation statements)

References 26 publications

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“…Our results indicated that mortality rates were much lower than those reported in other countries, including the United States, Japan, and Italy [5][6][7]. A relatively low rate has been also observed in younger Mexican individuals [8]. The reasons for these world differences, to date, remain unclear, but genetic and environmental factors may be involved.…”

Section: Discussioncontrasting

confidence: 50%

Cancer Mortality in Older Mexican Individuals (2000 – 2010)

Santiago¹

2014

Epidemiol

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Objective: Given the trends in aging worldwide, in Mexico, we determined trends in adjusted mortality rates due to cancer and 11 cancer subtypes in older individuals (>65 years) from 2000 to 2010.Methods: For this retrospective study, we collected data on mortality due to cancer from the registries of the National Institute of Statistics and Geography. Adjusted rates were calculated with a direct method based on the world standard population. Trend analysis was performed with a linear regression of the natural logarithm of the adjusted rate, and trends were evaluated with the Student´s t test.Results: During the studied period, the cancer mortality rates significantly declined from 630.21 to 573.03 (per 100,000 inhabitants) in the overall population. Similar declines were observed in women (from 548.81 to 490.09) and men (from 726.03 to 672.94). Significant declines in mortality rates were observed across several cancer subtypes, including esophageal, gastric, colorectal-anal, liver-biliary, pancreatic, and tracheal-bronchial-lung cancers. Significant increases in mortality rates were observed in colorectal and breast cancer, but no changes were observed in mortality rates due to prostate, ovarian, bladder, and non-Hodgkin lymphoma cancers. Conclusion:Mortality due to cancer in older Mexicans was lower than that observed in developed countries, and it significantly declined over the study period. Men had higher mortality rates than women. The highest mortality rates were due to breast and prostate cancer subtypes in older individuals.

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Section: Discussioncontrasting

confidence: 50%

Cancer Mortality in Older Mexican Individuals (2000 – 2010)

Santiago¹

2014

Epidemiol

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“…Previous publications describing the burden of cancer in Mexico have been limited in scope because of the analysis of only short time periods, inclusion of a limited number of cancers, [20][21][22][23][24][25][26][27] incomplete or too broad geographical coverage, [28][29][30][31] or special settings like the population covered by the social security system. [32][33][34] It has therefore been difficult to assess cancer trends across the country.…”

Section: Discussionmentioning

confidence: 99%

The burden of cancer in Mexico, 1990-2013

et al. 2016

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Objective. To analyze mortality and incidence for 28 cancers by deprivation status, age and sex from 1990 to 2013. Materials and methods. The data and methodological approaches provided by the Global Burden of Disease (GBD 2013) were used. Results. Trends from 1990 to 2013 show important changes in cancer epidemiology in Mexico. While some cancers show a decreasing trend in incidence and mortality (lung, cervical) others emerge as relevant health priorities (prostate, breast, stomach, colorectal and liver cancer). Age standardized incidence and mortality rates for all cancers are higher in the northern states while the central states show a decreasing trend in the mortality rate. The analysis show that infection related cancers like cervical or liver cancer play a bigger role in more deprived states and that cancers with risk factors related to lifestyle like colorectal cancer are more common in less marginalized states. Conclusions. The burden of cancer in Mexico shows complex regional patterns by age, sex, types of cancer and deprivation status. Creation of a national cancer registry is crucial.Keywords: cancer; burden of disease; mortality; incidence; social condition; cause of death; epidemiology ResumenObjetivo. Analizar la incidencia y la mortalidad de 28 tipos de cáncer por nivel de marginación, grupos de edad y sexo, de 1990 a 2013. Material y métodos. Los datos utilizados provienen del estudio de la Carga Global de Enfermedades (2013). Las entidades federativas se clasificaron de acuerdo con el índice de marginación del Consejo Nacional de Población. Resultados. Los datos muestran una tendencia decreciente para algunos cánceres (pulmón y cervical), mientras otros aparecen como prioritarios y relevantes (próstata, mama, estómago, colon e hígado). En el norte se observan incrementos regionales mayores en las tasas de incidencia y mortalidad estandarizadas por edad, mientras que en los estados del centro se observa una tendencia decreciente de la tasa de mortalidad. Conclusiones. La epidemiología del cáncer en México (en su mayoría basada en datos de mortalidad) presentan patrones regionales complejos por edad, sexo, tipo de cáncer e índice de marginación. Es vital la creación de un registro nacional para mejorar el seguimiento y evaluación de intervenciones preventivas y curativas.

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“…Typically, breast cancer is diagnosed at a relatively advanced stage (III and above) (8–9) when the chance of cure is reduced. The median age of breast cancer diagnosis is 51 years (approximately one decade younger than that of women in Europe or North America) and almost one-half of Mexican women are premenopausal at breast cancer diagnosis (6–8). …”

Section: Introductionmentioning

confidence: 99%

Recurrent BRCA1 and BRCA2 Mutations in Mexican Women with Breast Cancer

Torres-Mejı́a

Royer

Llacuachaqui

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Germline mutations in the BRCA1 and BRCA2 genes confer an estimated 58–80% lifetime risk of breast cancer. In general, screening is done for cancer patients if a relative has been diagnosed with breast or ovarian cancer. There are few data on the prevalence of mutations in these genes in Mexican women with breast cancer and this hampers efforts to develop screening policies in Mexico. Methods We screened 810 unselected women with breast cancer from three cities in Mexico (Mexico City, Veracruz and Monterrey) for mutations in BRCA1 and BRCA2, including a panel of 26 previously reported mutations. Results Thirty-five mutations were identified in 34 women (4.3% of total) including 20 BRCA1 mutations and 15 BRCA2 mutations. Twenty-two of the 35 mutations were recurrent mutations (62.8%). Only five of the 34 mutation carriers had a first-degree relative with breast cancer (three with BRCA1 and two with BRCA2 mutations). Conclusion These results support the rationale for a strategy of screening for recurrent mutations in all women with breast cancer in Mexico, as opposed to restricting screening to those with a sister or mother with breast or ovarian cancer. Impact These results will impact cancer genetic testing in Mexico and the identification of at-risk individuals who will benefit from increased surveillance.

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Trends in cancer mortality in Mexico, 1981–2007

Cited by 44 publications

References 26 publications

Cancer Mortality in Older Mexican Individuals (2000 – 2010)

Cancer Mortality in Older Mexican Individuals (2000 – 2010)

The burden of cancer in Mexico, 1990-2013

Recurrent BRCA1 and BRCA2 Mutations in Mexican Women with Breast Cancer

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