Trends in Cardiovascular Disease Risk Factors in Individuals With and Without Diabetes Mellitus in the Framingham Heart Study

Abstract

Background-Individuals with diabetes mellitus are at 2-to 3-fold increased risk for cardiovascular disease (CVD) relative to those without diabetes. Our objective was to examine CVD risk factor level changes among individuals with and without type 2 diabetes mellitus from 1970 to 2005 in the Framingham Heart Study. Methods and Results-We included 4195 participants (3990 with no diabetes and 205 with diabetes) 50 years of age and 3495 participants (3178 with no diabetes and 317 with diabetes) 60 years of age. Contemporaneous CVD risk factor levels were measured; linear regression models were used to assess the interaction between diabetes status and calendar year on CVD risk factor levels. Among 50-year-olds without diabetes mellitus, there was an increase in body mass index of 0.39 kg/m

The disparity between long-term survival in patients with and without diabetes following a first myocardial infarction did not change between 1989 and 2006: an analysis of 6,776 patients in the Northern Sweden MONICA Study

“…Data from the Framingham Study point to a greater decrease in cholesterol, similar decline in blood pressure and greater increase in body weight in diabetic patients compared with non-diabetic patients between 1970 and 2005 [17]. Between 1996 and 2003, Swedish type 2 diabetic patients showed decreased HbA 1c , blood pressure and cholesterol, although few patients achieved target levels [18].…”

Coronary Artery Disease and Diabetes Mellitus

“…Amongst adults with DM there is a prevalence of 75% to 85% of hypertension, 70% to 80% for elevated LDL, and 60% to 70% for obesity. 4 CAD is the main cause of death in both type 1 and type 2 DM, 5 and DM is associated with a 2 to 4-fold increased mortality risk from heart disease. Over 70% of people >65 years of age with DM will die from some form of heart disease or stroke.…”

Asociación entre diabetes mellitus y patología cardiovascular en la población adulta de Chile: estudio de la Encuesta Nacional de Salud 2009-2010

“…La prevalencia de ECVA en PD también ha sido estimada a partir de estudios prospectivos de cohortes y de estudios observacionales transversales en poblaciones de sobrevivientes [5][6][7][8][9] . En ellos, la ECVA ha sido diagnosticada con metodologías muy diversas, incluyendo determinaciones cuantitativas de las lesiones ateroscleróticas, autoreporte de patología o sintomatología cardiovascular, estimación de riesgo de patología vascular en base de la integración de factores de riesgo mayores en modelos matemáticos.…”