Trends in Childhood Cancer Incidence: Review of Environmental Linkages

Buka, Irena; Koranteng, Samuel Senyo; Osornio-Vargas, Álvaro

doi:10.1016/j.pcl.2006.11.010

Cited by 39 publications

(32 citation statements)

References 192 publications

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“…132 In the United States and Europe, there is concern that overall rates of childhood cancer have been increasing since 1970. 133 Early life exposures to pesticides are suspected to be responsible for some of these childhood leukemias. A number of recent systematic reviews of the etiological literature [134][135][136][137] reached a somewhat similar conclusion (ie, the current literature is limited).…”

Section: Leukemiamentioning

confidence: 99%

Increased cancer burden among pesticide applicators and others due to pesticide exposure

Alavanja

Ross

Bonner

2013

CA A Cancer J Clinicians

297

213

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A growing number of well-designed epidemiological and molecular studies provide substantial evidence that the pesticides used in agricultural, commercial, and home and garden applications are associated with excess cancer risk. This risk is associated both with those applying the pesticide and, under some conditions, those who are simply bystanders to the application. In this article, the epidemiological, molecular biology, and toxicological evidence emerging from recent literature assessing the link between specific pesticides and several cancers including prostate cancer, non-Hodgkin lymphoma, leukemia, multiple myeloma, and breast cancer are integrated. Although the review is not exhaustive in its scope or depth, the literature does strongly suggest that the public health problem is real. If we are to avoid the introduction of harmful chemicals into the environment in the future, the integrated efforts of molecular biology, pesticide toxicology, and epidemiology are needed to help identify the human carcinogens and thereby improve our understanding of human carcinogenicity and reduce cancer risk. CA Cancer J Clin 2013;63:120-142.

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Section: Leukemiamentioning

confidence: 99%

Increased cancer burden among pesticide applicators and others due to pesticide exposure

Alavanja

Ross

Bonner

2013

CA A Cancer J Clinicians

297

213

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“…1 2 Among the 12 major types of childhood cancer, the leukaemia group has the highest incidence (40% of all cancers); cancers of the brain, lymphomas and cancers of central nervous system account for more than 25% of new cases; neuroblastoma, Wilms' tumour and sarcoma are less common 3–5. In the USA and Europe, there is concern that overall rates of childhood cancer have been increasing since 1970 6. The risk factors for childhood cancer are largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Exposure to pesticides and risk of childhood cancer: a meta-analysis of recent epidemiological studies

Vinson

Merhi

Baldi

et al. 2011

Occupational and Environmental Medicine

116

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“…Unless more emphasis is given to aetiological research, this situation will continue. The results of the present study pose a new challenge: instead of questioning the rather unstable variations in secular trends, it might be better to focus on exploring the underlying causes of the wide cross-country variations in leukaemia (26–50/million) and lymphoma (12–27/million) incidence among children in the EU and worldwide12 33 in relation to changes in potential environmental risk factors and lifestyles 4 29 34…”

Section: Discussionmentioning

confidence: 96%

Childhood leukaemias and lymphomas in Greece (1996-2006): a nationwide registration study

Petridou¹,

Pourtsidis

Dessypris³

et al. 2008

Archives of Disease in Childhood

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Minimal secular changes in childhood leukaemias/lymphomas have been noted recently in the EU-27, which cannot be easily explained in countries with small populations. Therefore, centralised EU databases such as the Automated Childhood Cancer Information System (ACCIS) should be enlarged to generate sufficient statistical power for monitoring time trends. It would be interesting to explore whether different lifestyle patterns across the EU might be responsible for the observed excess leukaemia incidence in countries such as Greece.

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Trends in Childhood Cancer Incidence: Review of Environmental Linkages

Cited by 39 publications

References 192 publications

Increased cancer burden among pesticide applicators and others due to pesticide exposure

Increased cancer burden among pesticide applicators and others due to pesticide exposure

Exposure to pesticides and risk of childhood cancer: a meta-analysis of recent epidemiological studies

Childhood leukaemias and lymphomas in Greece (1996-2006): a nationwide registration study

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