Trends in clinical features and survival of oral cavity cancer: fifty years of experience with 3,362 consecutive cases from a single institution

Chen, Shu Wei; Zhang, Quan; Guo, Zhu Ming; Chen, Wen Kuan; Liu, Wei Wei; Chen, Yan Feng; Li, Qiuli; Liu, Xuekui; Li, Hao; Ouyang, Dian; Chen, Wei Chao; Xiao, Fu; Wang, Xi Di; Yang, Ankui; Bei, Jin‐Xin; Song, Ming

doi:10.2147/cmar.s171251

Cited by 53 publications

(43 citation statements)

References 23 publications

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“…With regard to the 5-year CS of OC patients, CS increased to 17% in patients who survived 1 year and to 13% in those who survived 5 years after the diagnosis (2007-2012 versus 2001-2006); similar results were observed in a single institution in the same period (37).…”

Section: ' Discussionsupporting

confidence: 73%

Survival trends of patients with oral and oropharyngeal cancer treated at a cancer center in São Paulo, Brazil

Kowalski¹,

Oliveira²,

López³

et al. 2020

Clinics

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OBJECTIVE:We aimed to estimate the overall survival (OS) and conditional survival (CS) in patients diagnosed with oral and oropharyngeal squamous cell carcinoma (SCC) and to determine their survival trends. METHODS:The study included all consecutive patients treated at the A.C. Camargo Cancer Center for oral or oropharyngeal SCC between 2001 and 2012. Data were obtained from the Hospital Cancer Registry. OS and CS were analyzed using the Kaplan-Meier method to evaluate the probability of survival with Cox predictor models. RESULTS: Data of 505 oral and 380 oropharyngeal SCC patients obtained in 2001-2006 and 2007-2012 were analyzed. Most of the oral SCC (59%) and oropharyngeal SCC (90%) patients had stages III-IV SCC. The 5-year OS for patients with oral SCC was 51.7%, with no significant difference between the first and second periods. The CS rates in 2007-2012 were 65% after the first year and 86% up to the fifth year. For oropharyngeal SCC, the 5-year OS rate was 45.0% in the first period. The survival rate increased to 49.1% from 2007 to 2012, with a reduction in the risk of death (HR=0.69;0.52-09.2). The CS estimates from 2007 to 2012 were 59% after the first year and 75% up to the fifth year. CONCLUSION: Survival across the two time periods remained stable for oral SCC but showed a significant increase for oropharyngeal SCC, possibly because of improvements in the patients' response to radiotherapy, such as intensity-modulated radiation therapy, and the use of more accurate diagnostic imaging approaches.

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Section: ' Discussionsupporting

confidence: 73%

Survival trends of patients with oral and oropharyngeal cancer treated at a cancer center in São Paulo, Brazil

Kowalski¹,

Oliveira²,

López³

et al. 2020

Clinics

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“…But in the above-mentioned two studies, the two groups had different tumor stage, node stage, and disease stage, all the variation could affect the comprehension of their outcome. The current study was firstly performed by a matched-pair design to shield the interfere of as many as confounding factors [20], it was noted NPC survivors had worse OS and DSS compared to sporadic oral SCC. At least the following three aspects called for consideration: in the one hand, there was negative prognostic effect of the previous radiotherapy on the survival of patients with oral SCC by prior researchers [21].…”

Section: Discussionmentioning

confidence: 99%

Secondary Squamous Cell Carcinoma of the Oral Cavity after Nasopharyngeal Carcinoma

Dai

Fang

et al. 2020

Cancer Res Treat

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The main goal of this study was to analyze the prognosis of secondary oral squamous cell carcinoma (SCC) with a comparison with sporadic oral SCC by a matched-pair design. Materials and Methods Records of patients with surgically treated primary oral SCC were reviewed, and a total of 83 patients with previous history of radiotherapy for nasopharyngeal carcinoma (NPC) were retrospectively enrolled. A matched-pair study was performed, each NPC survivor was matched with two sporadic oral SCC patients by age, sex, primary tumor site, adverse pathologic characteristics, disease stage, neck node status, and tumor stage. The overall survival (OS) and disease-specific survival (DSS) rates were calculated by the Kaplan-Meier method; independent prognostic factors were evaluated by the Cox proportional hazards method. Results Compared with sporadic oral SCC patients, NPC survivors were less likely to be smokers (p=0.004), perineural invasion and lymphovascular invasion were more common in NPC survivors (both p < 0.001). The 5-year OS and DSS rates in NPC survivors were 47% and 54%, respectively; the 5-year OS and DSS rates in sporadic oral SCC patients were 62% and 67%, respectively; the difference was significant (both p < 0.05). In survival analysis, disease stage remained to be independent prognostic factor for both the OS and DSS. Conclusion NPC survivors had worse OS and DSS than sporadic oral SCC patients, NPC survivors were less likely to be smokers, but had higher opportunity of perineural invasion and lymphovascular invasion. Disease stage was the most important predictor for the survival in NPC survivors.

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“…The first thing to take into consideration is that throughout the study period we were able to observe a progressive increase in the mean age at diagnosis of the HNSCC index tumor, which rose from 59.9 years in the group diagnosed during the first decade (1985‐1994) to 64.2 years for those diagnosed during the last period (2005‐2016). Several authors have described an increase in the mean age of patients with HNSCC over the past decades 17‐19 …”

Section: Discussionmentioning

confidence: 99%

Does age influence disease‐specific survival in patients with squamous cell carcinomas of the head and neck?

Lop

Valero

Garcı́a

et al. 2020

Journal of Surgical Oncology

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Background and Objectives: The number of patients diagnosed with head and neck squamous cell carcinoma (HNSCC) at an advanced age has increased. The aim of this study is to evaluate the age at which disease-specific survival (DSS) significantly decreases in HNSCC. Methods:We performed a retrospective study of 5469 patients with HNSCC treated at our center . External validation with 2082 oral squamous cell carcinomas from a collaborative institution from another continent was performed. Results:We observed an orderly decrease in overall survival as age at diagnosis increased. There were no differences in DSS based on age for patients <80 years old (P = .623), while older patients had a significant decrease in DSS. These results were validated in the independent dataset. In a multivariable analysis performed in the test set, compared to patients <80 years old, patients between 80 to 85 had a 1.50 times higher risk of disease-specific death (95% confidence interval [CI]: 1.19-1.89; P = .001), and patients >85 had a 2.19 times higher risk (95% CI: 1.68-2.87; P < .001).Conclusions: DSS started to significantly decrease in HNSCC at 80 years old. These findings, validated in an independent cohort, indicate that chronological age on its own should not withhold curative treatment in the majority of patients with HNSCC.

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Trends in clinical features and survival of oral cavity cancer: fifty years of experience with 3,362 consecutive cases from a single institution

Cited by 53 publications

References 23 publications

Survival trends of patients with oral and oropharyngeal cancer treated at a cancer center in São Paulo, Brazil

Survival trends of patients with oral and oropharyngeal cancer treated at a cancer center in São Paulo, Brazil

Secondary Squamous Cell Carcinoma of the Oral Cavity after Nasopharyngeal Carcinoma

Does age influence disease‐specific survival in patients with squamous cell carcinomas of the head and neck?

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