Trends in clinico-epidemiology profile of surgically operated glioma patients in a tertiary care center over 12 years—through the looking glass!

Abstract

Background Hospital-based cancer registries can provide information on the magnitude and distribution of cancers in a given hospital. Hospital-based brain tumor registry data, focusing on glioma, from a tertiary care rural neurological center is lacking in the scientific literature. This data can be useful in understanding the need for research and funding required for these specific brain tumors. Data of patients operated for glioma, at our institute, was collected between January 2004 and December 2015. Patients’ clinical details and histopathological diagnosis were recorded. Data were analyzed and compared with that of previously published literature, and inferences were drawn on patterns of reporting and epidemiology. Results A total of 1450 cases of glioma, with a mean age of 39.3 (± 17.36 SD) years with males (66.6%) comprising more population as compared to females. Majority of patients 70.8% (n = 1027) belong to the economically active age group of country (18–60 years). Majority of cases (41.4%) were glioblastoma with the next common tumor (22.8%) being diffuse astrocytoma (n = 331) followed by pilocytic astrocytoma (6.2%) and oligodendroglioma (4.5%) in that order. While our data followed similar trends with other Indian data the average age of glioma was a decade younger to what is quoted earlier in Indian and international studies. Conclusion This data for glioma gives a glimpse of the prevalence of this tumor in a primarily rural population and highlights the need for a National Brain Tumor Registry with the need for the development of evidence-based policymaking and enhanced research into this particular ailment.

Insights into the glioblastoma tumor microenvironment: current and emerging therapeutic approaches

“…GB is very uncommon in the pediatric population (Singla et al, 2021) and is found to be more prevalent in adult males (66.6% more) as compared to females. The gender-based age distribution in IDH-wildtype, TERT promoter mutation, EGFR gene amplification, +7/-10 chromosome copy-number alterations glioblastoma patients shows 70.5% males in the age group below 18 years, 69.7% males in the age group between 19 and 50 years and 72.8% males above 50 years (Singh et al, 2021). The number of cases is expected to rise with the rise in the elderly population, particularly in developing countries like the United States.…”