Trends in colorectal cancer incidence in Ho Chi Minh City, Vietnam (1996–2015): Joinpoint regression and age–period–cohort analyses

Pham, Dung X.; Phung, An; Nguyen, Hien; Bui, Tung D.; Mai, Linh D.; Tran, Bich; Tran, Thach; Nguyen, Tuan V.; Ho‐Pham, Lan T.

doi:10.1016/j.canep.2022.102113

Cited by 14 publications

(16 citation statements)

References 40 publications

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“…Meanwhile, the CRC cases among subjects aged ≥50 were mounting more dramatically, with an APC of +2.38% (p=0.041). A similar conclusion was reached by Pham et al 64 in the elderly Vietnamese population (APC+5.3%; 95% CI 2.8% to 7.9%). Hypothetically, this might happen because older patients were more likely to be included in screening programmes than young patients 64.…”

Section: Discussionsupporting

confidence: 84%

“…Given the rapid economic transition and urbanisation occurring in Indonesia, it is possible to generalise the upward CRC incidence trend in a single centre in Jakarta to all of Indonesia, 107 108 similar to what a study in Vietnam suggested. 64 However, as this is a single-centre study, the data presented may not be fully representative of other centres. Further research is needed to see if the trend can be reversed, for example, by evaluating current CRC screening standards and lowering the age at which people should begin screening.…”

Section: Discussionmentioning

confidence: 91%

“…The joinpoint regression analysis has significant analytic advantages for disease surveillance and, therefore, is valuable to portray trends in CRC incidence over time. This approach has been widely used in many CRC trend reports from several world regions, including North America (e.g., USA 54 and Canada 55 ), Latin America (e.g., Brazil 56 and Mexico 57 ), Europe (e.g., England 58 and Netherland 59 ), East Asia (e.g., China 60 and South Korea 61 ), the Middle East (e.g., Iran 62 and Lebanon 63 ), and Southeast Asia (e.g., Vietnam 64 and Thailand 65 ). Using this method, our first Indonesian study also successfully identified short-term CRC trend patterns that differed between young and old patients.…”

Section: Discussionmentioning

confidence: 99%

“…Hypothetically, this might happen because older patients were more likely to be included in screening programmes than young patients. 64 Since the population-based CRC screening programme has not been implemented in routine clinical practice in Indonesia, the actual rate of early-onset CRC might have been undervalued. The estimated cost of treatment for patients with CRC in Indonesia is US$116 083.37, 66 representing 0.000011% of the gross domestic product (GDP) in 2020.…”

Section: Discussionmentioning

confidence: 99%

“…8–10 In the next 10 years, the trend is predicted to shift to increasing rates of LSCRCs and RSCRCs otherwise due to greater exposure to specific cancer-related risk factors at the distal subsites. 64 106 114 It is linked to the increasing adoption of a Westernised lifestyle in Indonesia, as also growing in other Asian countries, is a reasonable ground for this shift. 84 115 The reasons for conflicting forecasts between young and old patients for CRC in overall and specifically RSCRC cases remain unclear.…”

Section: Discussionmentioning

confidence: 99%

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Analysing 11 years of incidence trends, clinicopathological characteristics, and forecasts of colorectal cancer in young and old patients: a retrospective cross-sectional study in an Indonesian national referral hospital

et al. 2022

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ObjectiveTo obtain annual incidence trends, understand clinicopathological characteristics, and forecast the future burden of colorectal cancer (CRC) in Indonesia.Design11-year retrospective cross-sectional study.SettingA national referral hospital in Jakarta, Indonesia.ParticipantsData from 1584 eligible cases were recorded for trends and forecasting analyses; 433 samples were analysed to determine clinicopathological differences between young (<50 years) and old (≥50 years) patients.MethodsTrend analyses were done using Joinpoint software, expressed in annual percentage change (APC), and a regression analysis was executed to generate a forecasting model. Patients’ characteristics were compared using χ2 or non-parametric tests.Main outcomesAnalysis of trends, forecasting model, and clinicopathological features between the age groups.ResultsA significant increase in APC was observed among old patients (+2.38%) for CRC cases. Colon cancer increased remarkably (+9.24%) among young patients; rectal cancer trends were either stable or declining. The trend for right-sided CRC increased in the general population (+6.52%) and old patients (+6.57%), while the trend for left-sided CRC was stable. These cases are expected to be a significant health burden within the next 10 years. Patients had a mean age of 53.17±13.94, 38.1% were young, and the sex ratio was 1.21. Prominent characteristics were left-sided CRC, tumour size ≥5 cm, exophytic growth, adenocarcinoma, histologically low grade, pT3, pN0, inadequately dissected lymph nodes (LNs), LN ratio <0.05, no distant metastasis, early-stage cancer, no lymphovascular invasion, and no perineural invasion (PNI). Distinct features between young and old patients were found in the histological subtype, number of dissected LN, and PNI of the tumour.ConclusionsEpidemiological trends and forecasting analyses of CRC cases in Indonesian patients showed an enormous increase in colon cancer in young patients, a particularly concerning trend. Additionally, young patients exhibited particular clinicopathological characteristics that contributed to disease severity.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Analysing 11 years of incidence trends, clinicopathological characteristics, and forecasts of colorectal cancer in young and old patients: a retrospective cross-sectional study in an Indonesian national referral hospital

et al. 2022

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Trends in head and neck cancer incidence in Ho Chi Minh City, Vietnam between 1996 and 2015

Deutsch,

Tran,

Pham

et al. 2024

Cancer Epidemiology

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Silymarin-Loaded Tin(IV) Nanoparticles Exhibit Enhanced Bioavailability and Antiproliferative Effects on Colorectal Cancer Cells

Abbasinia,

Heshmati,

Yousefi

et al. 2023

ACS Appl. Bio Mater.

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Silymarin (SM) exhibits potential therapeutic effects due to having antioxidant activity. However, the low solubility and bioavailability of SM restrict its biological performance. To overcome this limitation, this study aimed to develop a nanoformulation composed of SM and dimethyltindichloride and investigate the effect of SM-loaded Sn nanoparticles on cancer cell growth and survival. An SM−Sn complex was synthesized and then characterized using X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FTIR), EDS-MAP, dynamic light scattering (DLS), and ζ-potential analysis. After that, the SW480 colorectal cancer cell line was treated with different concentrations of SM and the SM−Sn complex. Cell viability was examined through the 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, analyzing apoptosis, and live−dead assay. The lipid peroxidation rate was assessed through the measurement of thiobarbituric acid (TBA). Intracellular reactive oxygen species (ROS) level and cell population in the cell cycle were measured using a flow cytometry instrument. To evaluate the colonization ability of SW480 cells, a colony formation assay was performed. Gene expression analysis was also conducted using a real-time polymerase chain reaction (PCR) technique. The findings of this study revealed the effectiveness of the SM−Sn complex in decreasing SW480 cell viability by inducing cell death-associated mechanisms. We found that the SM−Sn complex increases intracellular ROS level and malondialdehyde (MDA) content. It was also revealed that the SM−Sn complex induces cell cycle arrest and the expression of apoptotic genes. In addition, the SM−Sn complex could effectively hinder SW480 cells from constituting colonies. We conclude that the use of tin(IV) as a scaffold for enhanced delivery of SM could be considered an efficient option for inhibiting cancer cell proliferation and survival.

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Trends in colorectal cancer incidence in Ho Chi Minh City, Vietnam (1996–2015): Joinpoint regression and age–period–cohort analyses

Cited by 14 publications

References 40 publications

Analysing 11 years of incidence trends, clinicopathological characteristics, and forecasts of colorectal cancer in young and old patients: a retrospective cross-sectional study in an Indonesian national referral hospital

Analysing 11 years of incidence trends, clinicopathological characteristics, and forecasts of colorectal cancer in young and old patients: a retrospective cross-sectional study in an Indonesian national referral hospital

Trends in head and neck cancer incidence in Ho Chi Minh City, Vietnam between 1996 and 2015

Silymarin-Loaded Tin(IV) Nanoparticles Exhibit Enhanced Bioavailability and Antiproliferative Effects on Colorectal Cancer Cells

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