Trends in concentrations of selected dioxins and furans across various stages of kidney function for US adults

Jain, Ram B.

doi:10.1007/s11356-021-13844-3

Cited by 4 publications

(3 citation statements)

References 36 publications

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“…Through a multiple linear regression model analysis of 150 pregnant women, it was found that exposure to environmental pollutants may have negative effects, while exposure to greenspace may have positive effects on fetal renal function during pregnancy [ 45 ]. Epidemiological evidence indicated that the development of diabetes and chronic kidney disease was also associated with long-term exposure and accumulation of dioxins [ 46 , 47 , 48 ]. Jain [ 48 ] analyzed data from US adults from 1999 to 2004 to investigate concentration changes of four dioxin homologs and four separate furan homologs at various stages of renal function decline and found that renal dysfunction was associated with high dioxin/furan concentrations.…”

Section: Dioxinmentioning

confidence: 99%

“…Epidemiological evidence indicated that the development of diabetes and chronic kidney disease was also associated with long-term exposure and accumulation of dioxins [ 46 , 47 , 48 ]. Jain [ 48 ] analyzed data from US adults from 1999 to 2004 to investigate concentration changes of four dioxin homologs and four separate furan homologs at various stages of renal function decline and found that renal dysfunction was associated with high dioxin/furan concentrations.…”

Section: Dioxinmentioning

confidence: 99%

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The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease

Zhang

Flaws

Spinella

et al. 2022

Toxics

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Endocrine disrupting chemicals (EDCs) are exogenous substances that alter the endocrine function of an organism, to result in adverse effects on growth and development, metabolism, and reproductive function. The kidney is one of the most important organs in the urinary system and an accumulation point. Studies have shown that EDCs can cause proteinuria, affect glomeruli and renal tubules, and even lead to diabetes and renal fibrosis in animal and human studies. In this review, we discuss renal accumulation of select EDCs such as dioxins, per- and polyfluoroalkyl substances (PFAS), bisphenol A (BPA), and phthalates, and delineate how exposures to such EDCs cause renal lesions and diseases, including cancer. The regulation of typical EDCs with specific target genes and the activation of related pathways are summarized.

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Section: Dioxinmentioning

confidence: 99%

Section: Dioxinmentioning

confidence: 99%

The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease

Zhang

Flaws

Spinella

et al. 2022

Toxics

View full text Add to dashboard Cite

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“… 12 Two studies assessed multiple chemicals of the same type or class for one population group, 13 , 14 whereas four studies compared trends across multiple populations (different combinations of age, sex, race/ethnicity, and smoking status). 15 – 18 Although these works effectively use the longitudinal nature of the NHANES survey, they are in most cases limited to a small number of chemicals, usually of the same class, and a subset of the NHANES participants. One study, by Nguyen et al., used all NHANES participants to characterize age-based trends from urine biomarker concentrations across 141 of the NHANES chemicals.…”

Section: Introductionmentioning

confidence: 99%

Characterizing Chemical Exposure Trends from NHANES Urinary Biomonitoring Data

Stanfield,

Setzer,

Hull

et al. 2024

Environ Health Perspect

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Background: Xenobiotic metabolites are widely present in human urine and can indicate recent exposure to environmental chemicals. Proper inference of which chemicals contribute to these metabolites can inform human exposure and risk. Furthermore, longitudinal biomonitoring studies provide insight into how chemical exposures change over time. Objectives: We constructed an exposure landscape for as many human-exposure relevant chemicals over as large a time span as possible to characterize exposure trends across demographic groups and chemical types. Methods: We analyzed urine data of nine 2-y cohorts (1999–2016) from the National Health and Nutrition Examination Survey (NHANES). Chemical daily intake rates (in milligrams per kilogram bodyweight per day) were inferred, using the R package bayesmarker, from metabolite concentrations in each cohort individually to identify exposure trends. Trends for metabolites and parents were clustered to find chemicals with similar exposure patterns. Exposure variation by age, gender, and body mass index were also assessed. Results: Intake rates for 179 parent chemicals were inferred from 151 metabolites (96 measured in five or more cohorts). Seventeen metabolites and 44 parent chemicals exhibited fold-changes between any two cohorts (deltamethrin, di- -octyl phthalate, and di-isononyl phthalate had the greatest exposure increases). Di-2-ethylhexyl phthalate intake began decreasing in 2007, whereas both di-isobutyl and di-isononyl phthalate began increasing shortly before. Intake for four parabens was markedly higher in females, especially reproductive-age females, compared with males and children. Cadmium and arsenobetaine exhibited higher exposure for individuals years of age and lower for individuals years of age. Discussion: With appropriate analysis, NHANES indicates trends in chemical exposures over the past two decades. Decreases in exposure are observable as the result of regulatory action, with some being accompanied by increases in replacement chemicals. Age- and gender-specific variations in exposure were observed for multiple chemicals. Continued estimation of demographic-specific exposures is needed to both monitor and identify potential vulnerable populations. https://doi.org/10.1289/EHP12188

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Metformin attenuates PM _2.5 -induced oxidative stress by inhibiting the AhR/CYP1A1 pathway in proximal renal tubular epithelial cells

Cui,

Chen,

Zhang

et al. 2024

Toxicology Mechanisms and Methods

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Trends in concentrations of selected dioxins and furans across various stages of kidney function for US adults

Cited by 4 publications

References 36 publications

The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease

The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease

Characterizing Chemical Exposure Trends from NHANES Urinary Biomonitoring Data

Metformin attenuates PM _2.5 -induced oxidative stress by inhibiting the AhR/CYP1A1 pathway in proximal renal tubular epithelial cells

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Trends in concentrations of selected dioxins and furans across various stages of kidney function for US adults

Cited by 4 publications

References 36 publications

The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease

The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease

Characterizing Chemical Exposure Trends from NHANES Urinary Biomonitoring Data

Metformin attenuates PM 2.5 -induced oxidative stress by inhibiting the AhR/CYP1A1 pathway in proximal renal tubular epithelial cells

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Product

Resources

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Metformin attenuates PM _2.5 -induced oxidative stress by inhibiting the AhR/CYP1A1 pathway in proximal renal tubular epithelial cells