Trends in concept and nosology of autism spectrum disorder: A review

Gyawali, Shreeya; Patra, Bichitra Nanda

doi:10.1016/j.ajp.2019.01.021

Cited by 27 publications

(11 citation statements)

References 64 publications

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“…The Bacteroidetes phylum is responsible for polysaccharide digestion. Therefore, this research could support the theory that ASD patients have an abnormal digestion of carbohydrates and mucosal dysbiosis in the gut [1,43]. In other studies, a high level of Actinobacteria phylum was noticed in autistic patients in comparison with the control group.…”

Section: Evidence Linking Gut Microbiome Dysbiosis To Autismsupporting

confidence: 82%

“…Autism spectrum disorder (ASD) is a complicated neurodevelopmental disorder characterized by decreased verbal and social interactions, limited interests and activities, and repetitive behaviors [1,2]. Along with these significant conditions, ASD regularly co-occurs with other clinical symptoms, including gastrointestinal disturbances (up to 70%), motor deficits (79%), sleep problems (50-80%), and intellectual disability (45%) [3].…”

Section: Introductionmentioning

confidence: 99%

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The Human Gut Microbiome as a Potential Factor in Autism Spectrum Disorder

Al-Harthi

Alhazmi

Alburae

et al. 2022

IJMS

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The high prevalence of gastrointestinal (GI) disorders among autism spectrum disorder (ASD) patients has prompted scientists to look into the gut microbiota as a putative trigger in ASD pathogenesis. Thus, many studies have linked the gut microbial dysbiosis that is frequently observed in ASD patients with the modulation of brain function and social behavior, but little is known about this connection and its contribution to the etiology of ASD. This present review highlights the potential role of the microbiota–gut–brain axis in autism. In particular, it focuses on how gut microbiota dysbiosis may impact gut permeability, immune function, and the microbial metabolites in autistic people. We further discuss recent findings supporting the possible role of the gut microbiome in initiating epigenetic modifications and consider the potential role of this pathway in influencing the severity of ASD. Lastly, we summarize recent updates in microbiota-targeted therapies such as probiotics, prebiotics, dietary supplements, fecal microbiota transplantation, and microbiota transfer therapy. The findings of this paper reveal new insights into possible therapeutic interventions that may be used to reduce and cure ASD-related symptoms. However, well-designed research studies using large sample sizes are still required in this area of study.

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Section: Evidence Linking Gut Microbiome Dysbiosis To Autismsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

The Human Gut Microbiome as a Potential Factor in Autism Spectrum Disorder

Al-Harthi

Alhazmi

Alburae

et al. 2022

IJMS

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“…Highly prevalent suicidal behaviors and suicide have been reported among individuals suffering from ASD although, there is no prior study that ever examined the suicidality of mothers with ASD children (Gilson et al, 2018;Storch et al, 2013). Furthermore, the global ASD prevalence rates appear to be increasing and considering this increase (Gyawali, & Patra, 2019;Manohar et al, 2020), it is anticipated that a large proportion of the mothers with ASD children (MwASDC) is expected to experience psychiatric comorbidities compared to the mothers with typically developing children (MwTDC), including depression and suicidality, yet empirical evidence is lacking, and constitutes the specific aim of the present study.…”

Section: Introductionmentioning

confidence: 99%

Depression and suicidal behaviors among Bangladeshi mothers of children with Autism Spectrum Disorder: A comparative study

Jahan

Araf²,

Griffiths

et al. 2020

Asian Journal of Psychiatry

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…One of the cardinal features of autism spectrum disorders (ASD) are the persistent difficulties in social communication and interaction with others 40 . It has been suggested that the UBE3A gene dosage may have a causative effect upon the expression of autistic traits [8][9][10][11]41 .…”

Section: Discussionmentioning

confidence: 99%

Aberrant aggressive behavior in a mouse model of Angelman syndrome

Simchi

Kaphzan

2021

Sci Rep

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Angelman syndrome (AS) is a genetic neurodevelopmental disorder due to the absence of the E3-ligase protein, UBE3A. Inappropriate social interactions, usually hyper-sociability, is a part of that syndrome. In addition, clinical surveys and case reports describe aggressive behavior in AS individuals as a severe difficulty for caretakers. A mouse model for AS recapitulates most of the human AS phenotypes. However, very few studies utilized this mouse model for investigating affiliative social behavior, and not even a single study examined aggressive behavior. Hence, the aim of the herein study was to examine affiliative and aggressive social behavior. For that, we utilized a battery of behavioral paradigms, and performed detailed analyses of these behaviors. AS mice exhibited a unique characteristic of reduced habituation towards a social stimulus in comparison to their wild-type (WT) littermates. However, overall there were no additional marked differences in affiliative social behavior. In contrast to the mild changes in affiliative behavior, there was a striking enhanced aggression in the AS mice compared to their WT littermates. The herein findings emphasize the use of AS mouse model in characterizing and measuring inappropriate aggressive behavior, and suggests these as tools for investigating therapeutic interventions aimed at attenuating aggressive behavior.

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Trends in concept and nosology of autism spectrum disorder: A review

Cited by 27 publications

References 64 publications

The Human Gut Microbiome as a Potential Factor in Autism Spectrum Disorder

The Human Gut Microbiome as a Potential Factor in Autism Spectrum Disorder

Depression and suicidal behaviors among Bangladeshi mothers of children with Autism Spectrum Disorder: A comparative study

Aberrant aggressive behavior in a mouse model of Angelman syndrome

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