Trends in disease-specific survival of head and neck squamous cell carcinoma patients treated in a single institution over a 30-year period

León, Xavier; Orús, César; Casasayas, María; Neumann, Eduard; Holgado, Anna; Quer, Miquel

doi:10.1016/j.oraloncology.2021.105184

Cited by 11 publications

(6 citation statements)

References 17 publications

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“…Due to the anatomical sensitivity of these tumors and surrounding tissues, current treatment modalities may result in adverse effects such as mucositis, neurotoxicity, tissue/bone necrosis, fibrosis, or infection. 36 Although head and neck cancer (HNC) outcomes are improving, 37 , 38 , 39 new therapies should be pursued to improve patient quality of life and care. Nanomedicine has immense potential in the treatment of cancers of the head and neck due to its targeted approach and potential for reduced side effects.…”

Section: Resultsmentioning

confidence: 99%

The current status of nanotechnological approaches to therapy and drug delivery in otolaryngology: A contemporary review

Burruss

Kacker

2022

Laryngoscope Investig Oto

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Objectives/Hypothesis: To summarize the current standing of nanomedicine-based technology, particularly nanoparticles (NPs), for drug delivery and diagnostic mechanisms in otolaryngology and the otolaryngology subspecialties. Methods: Literature searches were performed using PubMed and Ovid MEDLINE from 2010 to 2022. The search focused on original articles describing developments and applications of nanotechnology and drug delivery in otology, neurotology, cranial base surgery, head and neck oncology, laryngology, bronchoesophagology, and rhinology. Keyword searches and cross-referencing were also performed. No statistical analysis was performed. Results: The PubMed search yielded 29 articles, and two Ovid MEDLINE searches both yielded 7 and 26 articles, respectively. Cross-referencing and keyword searches in PubMed and Google Scholar yielded numerous articles. The results indicate that currently, NPs are the most thoroughly studied nanotechnology for drug delivery and therapy in otolaryngology. Organic NPs have been utilized for drug

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Section: Resultsmentioning

confidence: 99%

The current status of nanotechnological approaches to therapy and drug delivery in otolaryngology: A contemporary review

Burruss

Kacker

2022

Laryngoscope Investig Oto

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“…Recent advances in the diagnosis and treatment of PwHNC have significantly improved the survival of PwHNC (10). As a result, there are more long-term survivors (11), and, especially under new approaches such as immunotherapy (ICT-immune-checkpoint therapy), a small group of PwHNC can reach stable remissions even in a primary incurable situation (12). Therefore, other dimensions of the treatment outcome, such as physical status and functional abilities, psychological status and wellbeing, are becoming increasingly important (13).…”

Section: Introductionmentioning

confidence: 99%

Feasibility of individualized home exercise programs for patients with head and neck cancer – study protocol and first results of a multicentre single-arm intervention trial (OSHO #94)

Felser,

Rogahn,

Glass

et al. 2024

Preprint

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Introduction Patients with head and neck cancer (PwHNC) benefit from targeted exercise interventions: symptom relief, compensation for dysfunction, improvement in quality of life (QoL). Data on acceptance physical interventions in PwHNC are rare. The ‘OSHO #94’ trial investigates the short- and medium-term effects of individualized home exercise in PwHNC on QoL, physical activity and functionality. The study includes a feasibility phase in order to evaluate the acceptance (Phase A), followed by a consecutive QoL endpoint Phase B. Here we present the study protocol as well as the feasibility results. Methods and analysis This prospective, multicentre, single-arm intervention study includes PwHNC ≥18 years of age in aftercare or palliative care with stable remission under immunotherapy. The study opened in January 01, 2021, with estimated completion by December 31, 2024. The PwHNC receive an individualized home exercise program consisting of mobilization, coordination, strengthening and stretching exercises. This should be carried out at least three times a week over 12 weeks for 15 to 30 minutes, supplemented by aerobic training two to three times a week for 30 minutes (intervention). Once weekly telephone calls with a physiotherapist are performed. Subsequently, there is a 12-week follow-up (FU) without exercise specifications/contact. Outcomes are measured before and after the intervention and following the FU. Primary outcome of the feasibility phase (Phase A, n = 25) was the determination of the dropout rate during the intervention with a termination cut off if more than 30% PwHNC withdrew premature. The primary outcome of phases A + B (N = 53) are the change in global QoL score from pre- to post-intervention (EORTC QLQ-C30). Secondary outcomes include clinical and patient-reported measures, training details as well as functional diagnostic data (e.g. level of physical activity, training frequency, flexibility, fall risk and aerobic performance). Results 25 PwHNC were enrolled onto the feasibility cohort. Only16% (4/25 patients) did not complete the study. Therefore, individualized home exercise programs in PwHNC seem feasible recruitment of PwHNC for phase B continued. The dropout rate was adjusted from 30% (N = 60) to 20% (N = 53, calculated sample size n = 42 PwHNC and 20% (n = 11) to dropout). Ethics and dissemination The study protocol was approved by the Ethics Committee of the University of Rostock, University of Halle-Wittenberg and University of Greifswald. The findings will be disseminated in peer-reviewed journals and academic conferences. Trial registration German Registry of Clinical Trials DRKS00023883.

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“…Head and neck (HN) tumours, the most common type being squamous cell carcinomas (SCCs), affect the epithelium of distinct head and neck topologies, including the pharynx and larynx, and more frequently the oral cavity 27 and show different clinical courses. The five-year survival rate is low in HNSCC, although a significant increase in the disease-specific survival of patients has been observed in recent years 28 – 30 One reason for the low survival is that patients with tumours in early stages frequently exhibit few symptoms, resulting in delayed diagnosis and severe morbidity. Even if an early diagnosis is made, recurrence—a frequent event associated with a poor survival prognosis in HNSCC—is unpredictable.…”

Section: Introductionmentioning

confidence: 99%

Plasma metabolomics of oral squamous cell carcinomas based on NMR and MS approaches provides biomarker identification and survival prediction

Polachini

Castro

Smarra

et al. 2023

Sci Rep

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Metabolomics has proven to be an important omics approach to understand the molecular pathways underlying the tumour phenotype and to identify new clinically useful markers. The literature on cancer has illustrated the potential of this approach as a diagnostic and prognostic tool. The present study aimed to analyse the plasma metabolic profile of patients with oral squamous cell carcinoma (OSCC) and controls and to compare patients with metastatic and primary tumours at different stages and subsites using nuclear magnetic resonance and mass spectrometry. To our knowledge, this is the only report that compared patients at different stages and subsites and replicates collected in diverse institutions at different times using these methodologies. Our results showed a plasma metabolic OSCC profile suggestive of abnormal ketogenesis, lipogenesis and energy metabolism, which is already present in early phases but is more evident in advanced stages of the disease. Reduced levels of several metabolites were also associated with an unfavorable prognosis. The observed metabolomic alterations may contribute to inflammation, immune response inhibition and tumour growth, and may be explained by four nonexclusive views—differential synthesis, uptake, release, and degradation of metabolites. The interpretation that assimilates these views is the cross talk between neoplastic and normal cells in the tumour microenvironment or in more distant anatomical sites, connected by biofluids, signalling molecules and vesicles. Additional population samples to evaluate the details of these molecular processes may lead to the discovery of new biomarkers and novel strategies for OSCC prevention and treatment.

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Trends in disease-specific survival of head and neck squamous cell carcinoma patients treated in a single institution over a 30-year period

Cited by 11 publications

References 17 publications

The current status of nanotechnological approaches to therapy and drug delivery in otolaryngology: A contemporary review

The current status of nanotechnological approaches to therapy and drug delivery in otolaryngology: A contemporary review

Feasibility of individualized home exercise programs for patients with head and neck cancer – study protocol and first results of a multicentre single-arm intervention trial (OSHO #94)

Plasma metabolomics of oral squamous cell carcinomas based on NMR and MS approaches provides biomarker identification and survival prediction

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