Trends in documented cannabis use disorder among hospitalized adult epilepsy patients in the United States

Lekoubou, Alain; Fox, Jonah; Bishu, Kinfe G.; Ovbiagele, Bruce

doi:10.1016/j.eplepsyres.2020.106341

Cited by 5 publications

(20 citation statements)

References 18 publications

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“…The following section is summarized in Table 1 . Of the 66 included studies, 45 (68%) included only or mostly (i.e., >50%) adult participants ( 10 , 11 , 22 , 24 – 28 , 30 , 32 , 33 , 36 – 39 , 41 – 43 , 46 , 48 – 50 , 52 – 63 , 66 – 68 , 71 , 72 , 75 , 76 , 78 – 80 , 83 ), whereas 21 (32%) included only or mostly (i.e., >50%) pediatric participants ( 21 , 23 , 29 , 31 , 34 , 35 , 40 , 44 , 45 , 47 , 51 , 64 , 65 , 69 , 70 , 73 , 74 , 77 , 81 , 82 , 84 ). Most studies (88%), both adult and pediatric, were published after 2010 ( 10 , 11 , 21 – 29 , 31 , 32 , 34 , 35 , 38 – 58 , 60 – 66 , 69 – 84 ).…”

Section: Resultsmentioning

confidence: 99%

“…Most studies (88%), both adult and pediatric, were published after 2010 ( 10 , 11 , 21 – 29 , 31 , 32 , 34 , 35 , 38 – 58 , 60 – 66 , 69 – 84 ). Most studies originated from the USA (52%) ( 10 , 23 , 27 – 31 , 33 , 39 – 42 , 45 , 46 , 50 – 54 , 58 – 65 , 70 – 73 , 78 , 84 ), Canada (12%) ( 11 , 21 , 32 , 36 , 48 , 49 , 80 ), and Germany (7.6%) ( 21 , 37 , 38 , 44 , 68 , 79 ). Most studies consisted in journal articles (68%) ( 10 , 21 , 23 , 25 – 28 , 30 , 31 , 33 – 40 , 43 – 46 , 48 , 50 – 53 , 57 – 59 , 61 , 62 , 64 – 68 , 70 , 72 – 77 , 79 , 80 ,…”

Section: Resultsmentioning

confidence: 99%

“…Most studies originated from the USA (52%) ( 10 , 23 , 27 – 31 , 33 , 39 – 42 , 45 , 46 , 50 – 54 , 58 – 65 , 70 – 73 , 78 , 84 ), Canada (12%) ( 11 , 21 , 32 , 36 , 48 , 49 , 80 ), and Germany (7.6%) ( 21 , 37 , 38 , 44 , 68 , 79 ). Most studies consisted in journal articles (68%) ( 10 , 21 , 23 , 25 – 28 , 30 , 31 , 33 – 40 , 43 – 46 , 48 , 50 – 53 , 57 – 59 , 61 , 62 , 64 – 68 , 70 , 72 – 77 , 79 , 80 , 84 ). The most popular journal was Epilepsy & Behavior, which published 17 (24%) studies in total ( 10 , 11 , 23 , 25 , 31 , 39 , 40 , 44 , 46 , 53 , 64 , 65 , 67 ...…”

Section: Resultsmentioning

confidence: 99%

“…The most popular journal was Epilepsy & Behavior, which published 17 (24%) studies in total ( 10 , 11 , 23 , 25 , 31 , 39 , 40 , 44 , 46 , 53 , 64 , 65 , 67 , 72 , 73 , 75 , 79 , 84 ). Studies were most frequently cross-sectional (68%) ( 10 , 11 , 21 – 29 , 31 – 33 , 36 – 38 , 40 – 44 , 49 , 50 , 52 – 56 , 61 , 62 , 64 , 66 – 68 , 71 , 73 , 75 , 76 , 78 – 80 , 82 – 84 ) or case reports/series (21%) ( 30 , 34 , 39 , 46 – 48 , 51 , 57 , 58 , 60 , 63 , 68 , 77 , 81 ). A few studies were qualitative (4.6%) ( 35 , 70 , 74 ) or longitudinal (6.1%) ( 45 , 59 , 65 , 72 ).…”

Section: Resultsmentioning

confidence: 99%

“…The prevalence of NMC use in PWE was extremely variable and depended upon the study populations at hand and methodological factors. Most studies reported lifetime prevalence of NMC use in PWE grossly between 10 and 40% (25,31,33,38,43,44,49,53,54,59,66,67,75,76,(78)(79)(80)82). The two largest studies (with sample sizes several 100,000s larger than every other study) reported prevalence of NMC use in PWE of <10%, though these were prevalence for "cannabis use disorder" in people hospitalized with epilepsy (50, 61).…”

Section: Discussionmentioning

confidence: 99%

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Use of non-medical cannabis in epilepsy: A scoping review

Areal²,

Toffa³

et al. 2023

Front. Neurol.

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ObjectiveThe use of medical cannabis among people with epilepsy (PWE) has been garnering increasing interest. In this scoping review, we aimed to summarize the literature on recreational/non-medical cannabis (NMC) use in PWE, focusing on the experience, habits, and beliefs of PWE regarding NMC.MethodsFour databases (OVID Medline, OVID Embase, Ovid APA PsycInfo, and Web of Science) were searched for studies describing NMC use in PWE. NMC was defined as cannabis products procured from sources other than by prescription. Studies that consisted in original research and that detailed the experience, habits, and/or beliefs of PWE regarding NMC use were included in the analysis. Data pertaining to study identification, demographics, NMC use, and epilepsy characteristics were extracted. Descriptive statistical analyses and reflexive thematic analyses were performed to map these data.ResultsIn total, 3,228 records were screened, and 66 were included for analysis: 45 had mainly adult samples, whereas 21 had mainly pediatric samples. Most studies were published after 2010, originated from the USA, and were cross-sectional. The median number of PWE using cannabis in these studies was 24.5 (1–37,945). No studies showcased elderly PWE, and most had predominantly Caucasian samples. The lifetime prevalence of NMC use in PWE was variable, ranging between 0.69 and 76.8%. Factors frequently associated with NMC use in PWE were male sex, younger adult age, and lower education status. Children with epilepsy took NMC primarily for seizure control, using high CBD/THC ratios, and only orally. Adults with epilepsy took NMC for various reasons including recreationally, using variable CBD/THC ratios, and predominantly through smoking. The majority of PWE across all studies perceived that NMC aided in seizure control. Other aspects pertaining to NMC use in PWE were rarely reported and often conflicting.ConclusionThe literature on NMC use in PWE is sparse and heterogeneous, with many salient knowledge gaps. Further research is necessary to better understanding the experience, habits, and beliefs of PWE pertaining to NMC.

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