Trends in Drug Discovery over Five Decades – The European Federation for Medicinal Chemistry International Symposium on Medicinal Chemistry (EFMC−ISMC)

Differding, Edmond

doi:10.1002/cmdc.202000840

Cited by 3 publications

(4 citation statements)

References 18 publications

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“…Таким образом, хотя в выполнении научно-исследовательских и опытноконструкторских работ (НИОКР) важен успех на каждом этапе, однако правильный выбор стратегии на самом раннем этапе остается решающим. [20,21]. Актуальность этой тематики составляла менее 15% до 2016 года, а затем снова повысилась в 2018 году.…”

Section: результаты и обсуждениеunclassified

“…Тематика ССЗ поднялась на вторую позицию в 1980-х (13,1%) и 1990-х годах (14,5%). Однако из-за резкого сокращения количества лекций, посвященных ССЗ, в конце 1990-х годов эта тематика с тех пор занимает одно из последних мест с 3,6% в 2000-х и 3,9% в 2010-х [20]. Это соответствует сокращению фармацевтических исследований и разработок в этом районе и его стагнации в течение двух десятилетий [23].…”

Section: тенденции разработки лс по терапевтическим областямunclassified

“…Другие терапевтические области вносят меньший вклад в современные программы симпозиума [20]: иммунология до 10%, метаболические расстройства до 10%, вопросы анальгезии до 7%, респираторные заболевания -1%. Значительное количество других терапевтических направлений лишь спорадически появлялось в программах ISMC, таких как заболевания опорно-двигательного аппарата, желудочнокишечные заболевания, оториноларингология, репродукция, нарушения сна, урология / нефрология, дерматология и офтальмология.…”

Section: тенденции разработки лс по терапевтическим областямunclassified

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Overview of drugs approved by the FDA in 2022

Kurkin,

Morkovin,

Bakulin

et al. 2023

Farm. farmakol. (Pâtigorsk)

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The aim of the work is to conduct a review of medications approved by the FDA in 2022.Materials and methods. In searching for the materials to write this review article, bibliographic databases including PubMed, Google Scholar and e-library.ru were utilized. The search was conducted for the publications spanning the period from 2008 to 2023. Herewith, the following keywords and word combinations were used: new drug approval, NDA, drug authorization, approval package, breakthrough medicine.Results. The discovery and development of medications are among the most crucial scientific processes in healthcare. Developing a new drug is a highly intricate, expensive, and time-consuming process. Nowadays, the problem of costs reduction and the process of expedited discovering of new medications are particularly pertinent. To optimize the search for active compounds, virtual and high-throughput screenings, machine learning, artificial intelligence, cryo-electron microscopy, and drug repurposing are employed. Simultaneously, the search for original molecules to serve as the basis for innovative drugs continues. This article presents a review of medications approved by the FDA in 2022 for the treatment of various pathologies.Conclusion. A drug development is a complex and resource-intensive process, with only a small fraction of candidates advancing to clinical trials. A drug design evolves in tandem with societal needs, and this review highlights some of the medications approved by the FDA in 2022. Technological advancements are expected to expedite drug development, potentially reducing the time to the market. Biotechnology, including cell therapy, holds significant prospects, and achievements in genetic mapping and chip technologies will enhance the accessibility of personalized pharmacology.

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Section: результаты и обсуждениеunclassified

Section: тенденции разработки лс по терапевтическим областямunclassified

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Overview of drugs approved by the FDA in 2022

Kurkin,

Morkovin,

Bakulin

et al. 2023

Farm. farmakol. (Pâtigorsk)

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“…A follow-up article will analyze the talks presented in the series EFMC-International Symposium on Medicinal Chemistry (EFMC-ISMC), to illustrate how topics changed over five decades. [10] Two clarifications are noteworthy at the outset. First, given the limited information available, in particular, on the federation's early years, and sometimes even conflicting data depending on the sources used, we made efforts to include as much information as possible, flagging major discrepancies where necessary.…”

Section: Introductionmentioning

confidence: 99%

50 Years European Federation for Medicinal Chemistry (EFMC) – The Ascent of Medicinal Chemistry in Europe

Differding¹

2020

ChemMedChem

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A historical overview of key events that led, 50 years ago, to the foundation of the European Federation for Medicinal Chemistry (EFMC), and the impact this had on promoting and structuring medicinal chemistry as a discipline in Europe. EFMC, together with the growing number of newly established national medicinal chemistry societies or divisions, created the framework for networking and knowledge exchange. This includes organizing conferences, in particular its biennial ‘International Symposium on Medicinal Chemistry (EFMC‐ISMC)’. Several interesting trends can be identified from EFMC meetings, EFMC governing bodies, or the federation's recognition of scientific excellence, that highlight changes in the medicinal chemistry community over the last decades, related to affiliation, gender, young scientists, communication tools, and embracing scientific advances.

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Fabulous at Fifteen!

Peralta

2021

ChemMedChem

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Trends in Drug Discovery over Five Decades – The European Federation for Medicinal Chemistry International Symposium on Medicinal Chemistry (EFMC−ISMC)

Cited by 3 publications

References 18 publications

Overview of drugs approved by the FDA in 2022

Overview of drugs approved by the FDA in 2022

50 Years European Federation for Medicinal Chemistry (EFMC) – The Ascent of Medicinal Chemistry in Europe

Fabulous at Fifteen!

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