Trends in eczema in the first 18 years of life: results from the Isle of Wight 1989 birth cohort study

Ziyab, Ali H.; Raza, Abid; Karmaus, Wilfried; Tongue, Nicky; Zhang, Hongmei; Matthews, S.; Arshad, Syed Hasan; Roberts, Graham

doi:10.1111/j.1365-2222.2010.03633.x

Cited by 60 publications

(69 citation statements)

References 36 publications

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“…6,23,28,31,44,45,48 The duration of AD persistence was significantly higher in females (median: 9.0 years; mean ± SE: 12.7 ± 0.2 years) compared with males (median: 7.0 years; mean±SE: 11.7 ± 0.2 years) (HR 1.15; 95% CI 1.04-1.27; P = .006) (Fig 2, E).…”

Section: Ad Persistence By Gendermentioning

confidence: 90%

“…After review of the titles and abstracts, 9326 were excluded; an additional 634 articles were excluded after full-text review. In total, 46 studies were included in the review, of which 44 had valid frequency data that could be pooled, 7 had valid data to assess the effects of gender, 6,23,28,31,44,45,48 6 for allergen sensitization, 6,17,23,36,40,45 and 3 for baseline AD severity 17,28,40 on disease persistence. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram is presented in Fig 1. …”

Section: Literature Searchmentioning

confidence: 99%

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Persistence of atopic dermatitis (AD): A systematic review and meta-analysis

Kim

Chao

Simpson

et al. 2016

Journal of the American Academy of Dermatology

211

156

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Section: Ad Persistence By Gendermentioning

confidence: 90%

Section: Literature Searchmentioning

confidence: 99%

Persistence of atopic dermatitis (AD): A systematic review and meta-analysis

Kim

Chao

Simpson

et al. 2016

Journal of the American Academy of Dermatology

211

156

View full text Add to dashboard Cite

show abstract

“…Females also have an approximately 30% greater risk of developing inflammatory bowel diseases, such as Crohn's disease, than males (16). As a result of elevated immunity among females, many inflammatory-mediated diseases, including eczema, allergy, asthma, and inflammatory bowel diseases are more frequent and more severe in females than males, with disease severity often changing at puberty, during the menstrual cycle, and after menopause (2,16,80).…”

Section: Inflammatory Diseasesmentioning

confidence: 98%

Immune Cells Have Sex and So Should Journal Articles

2012

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Males and females have the same immunological cells, proteins, and pathways in place to protect against the development of disease. The kinetics, magnitude, and skewing of the responses mounted against pathogens, allergens, toxins, or self-antigens, however, can differ dramatically between the sexes. Generally, females mount higher innate and adaptive immune responses than males, which can result in faster clearance of pathogens but also contributes to increased susceptibility to inflammatory and autoimmune diseases in females compared with males. Hormonal and genetic factors contribute significantly to sex differences in immune function and disease pathogenesis. In particular, the expression of X-linked genes and microRNA as well as sex steroid hormones signaling through hormone receptors in immune cells can affect responses to immunological stimuli differently in males and females. Despite data illustrating profound differences between the sexes in immune function, sex differences in the pathogenesis of disease are often overlooked in biomedical research. Establishing journal policies that require authors to report the sex of their cells, animals, and subjects will improve our understanding of the pathogenesis of diseases, with the long-term goal of personalizing treatments for immune-mediated diseases differently for males and females in an effort to protect us equally.

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“…De los pacientes, la mayoría fue del sexo masculino (56.7 %), tendencia que persistió en el resto de las patologías alérgicas y concuerda con los datos evidenciados en la mayoría de la literatura internacional. 5,6,7,8,9,10,11,12 En un estudio regional previo no se identifi có diferencia en la prevalencia de rinitis y asma en la población preescolar entre hombres y mujeres. 4 Un aspecto importante es el análisis de los regí-menes de aseguramiento.…”

Section: Discussionunclassified

Caracterización de los niños menores de cinco años con sospecha de enfermedades alérgicas

Vásquez

Olaya

Cleves

et al. 2018

RAM

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Antecedentes: Los síntomas de enfermedad alérgica constituyen una causa frecuente de consulta en la infancia.Objetivo: Describir el perfil de una población de preescolares colombianos atendidos en un servicio de alergología y evaluar los posibles factores de riesgo.Métodos: Estudio descriptivo trasversal de pacientes menores de cinco años evaluados durante un año. Se realizó historia clínica completa y estudio alergológico con pruebas cutáneas según el caso. Se analizaron factores de riesgo mediante análisis multivariado.Resultados: Se incluyeron 674 pacientes, 382 (52.7 %) hombres. La mediana de edad fue 34 meses. Los motivos de consulta fueron tos o sibilancias recurrentes (54.3 %), rinitis (48.7 %) y eccema (32.2 %). Se realizaron pruebas cutáneas con aeroalérgenos a 299 pacientes (48 %) y con alimentos a 170 (27 %), encontrando positividad en 114 (38 %) y 16 (9.4 %), respectivamente. Los principales sensibilizadores fueron los ácaros y el huevo. Se encontró asociación directa entre eccema y prematurez (OR = 0.496; IC 95 % = 0.289-0.823), tos/sibilancias recurrentes e historia familiar de alergia (OR = 1.837; IC 95 % = 1.306-2.586), y tos/sibilancias recurrentes y antecedente de bronquiolitis (OR = 2.646; IC 95 % = 1.812-3.886).Conclusión: Los síntomas respiratorios representaron la principal causa de consulta. Los ácaros fueron los alérgenos más identificados. La historia familiar de alergia y la bronquiolitis parecen ser factores de riesgo.

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Trends in eczema in the first 18 years of life: results from the Isle of Wight 1989 birth cohort study

Abstract: We found only a minimal reduction in the prevalence of eczema during childhood and adolescence. During adolescence, more girls develop eczema and more boys outgrow it suggesting a role for gender-specific pubertal factors.

Cited by 60 publications

References 36 publications

Persistence of atopic dermatitis (AD): A systematic review and meta-analysis

Persistence of atopic dermatitis (AD): A systematic review and meta-analysis

Immune Cells Have Sex and So Should Journal Articles

Caracterización de los niños menores de cinco años con sospecha de enfermedades alérgicas

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