Trends in elective terminations of pregnancy between 1989 and 2000 in a French county (the Isère)

Guillem, Pascale; Fabre, Bibiana; Cans, Chantal; Robert-Gnansia, Élisabeth; Jouk, Pierre‐Simon

doi:10.1002/pd.711

Cited by 50 publications

(44 citation statements)

References 17 publications

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“…The reason for this rise may be the growing use of echocardiogram as a complementary scan, as well as the increasing experience of fetal heart screening among the obstetricians in Turkey. In our series, the most common chromosomal anomaly was trisomy 21, which was consistent with the other studies (4,7,8).…”

Section: Discussionsupporting

confidence: 82%

“…Central nervous system anomalies accounted for more than half of the indications for both early and late terminations. This finding is consistent with the studies which showed that central nervous system malformations are the most common structural malformations leading to the TOP (4,7,8,12,13). Fetal autopsy has a particularly valuable role in the counseling of families after the TOP (14).…”

Section: Discussionsupporting

confidence: 81%

“…In spite of the improvement in screening and detection of chromosomal anomalies in Turkey, the overall proportion of TOP due to chromosomal anomalies in our study (9.4%) was still lower than that in the previous studies (30-39%) (4,7,8). The reason for this low rate might be the religious and cultural factors which lead fewer couples to accept karyotype analysis or termination in comparison to the couples in Western countries.…”

Section: Discussioncontrasting

confidence: 54%

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Trends in fetal indications for termination of pregnancy between 2002 and 2010 at a tertiary referral centre

Çorbacıoğlu¹,

Aslan²,

Aydın³

et al. 2012

J Turkish German Gynecol Assoc

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Objective:We reviewed the data of the termination of pregnancy (TOP) cases between 2002 and 2010 to evaluate the changes in fetal indications for both early and late TOPs in this period. Material and Methods:The data of 962 TOP cases were analysed in two groups according to the periods as in 2002-2006 and 2007-2010. The women were also subdivided into two categories according to their gestational age; <23 weeks' gestation (early termination) and ≥23 weeks' gestation (late termination).Results: Four hundred and fifty-eight (47.6%) of TOPs were performed between 2002 and 2006 (Group 1) and 504 (52.3%) were performed between 2007 and 2010 (Group 2). The number of early (<23 weeks) and late (≥23 weeks) terminations were 583 (60.6%) and 379 (39.3%), respectively. The vast majority of anomalies were central nervous sytem malformations (51.8%). They were followed by multiple anomalies (10.2%) and chromosomal anomalies (9.4%). Chromosomal and cardiovascular system anomalies were significantly higher in 2007-2010 in comparison to 2002-2006 (p<0.0001 and p=0.002, respectively). There was no statistically significant difference between the fetal indications that led to early termination compared to those that led to late termination. Conclusion:The distribution of indications for TOP was influenced by the development in prenatal screening policy, resulting in a significant increase in terminations due to chromosomal and cardiovascular system anomalies. Cultural, educational, religious and legal factors cause differences in the indications for TOP as well as the gestational age that TOPS are performed. Sonuç: Terminasyon endikasyonlarının dağılımı prenatal tarama politikalarındaki gelişimden etkilenmiş, buna bağlı olarak kromozom ve kardiyovaskuler sistem anomalileri nedeniyle yapılan terminasyonların sayısı önemli ölçüde artmıştır. Kültürel, eğitimsel, dini ve yasal faktörler terminasyon yapıldığı gebelik haftasının yanı sıra terminasyon endikasyonlarında da değişikliklere yol açmaktadır. (J Turkish-German Gynecol Assoc 2012; 13: 85-90)

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 81%

Section: Discussioncontrasting

confidence: 54%

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Trends in fetal indications for termination of pregnancy between 2002 and 2010 at a tertiary referral centre

Çorbacıoğlu¹,

Aslan²,

Aydın³

et al. 2012

J Turkish German Gynecol Assoc

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“…There are few published data on the prevalence of TOPFA at a GA of 24 weeks or more, beyond the viability limit and the type of anomalies diagnosed in these pregnancies. A French study 2 described the termination of pregnancy after 12 weeks of gestation from 1989 to 2000 for all fetal and maternal indications. In 74% of all terminations, the indication was fetal anomaly (39% with structural malformations and 35% with chromosomal anomalies).…”

Section: Introductionmentioning

confidence: 99%

Termination of pregnancy for fetal anomaly after 23 weeks of gestation: a European register‐based study

Garne

Khoshnood

Loane

et al. 2010

BJOG

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Please cite this paper as: Garne E, Khoshnood B, Loane M, Boyd P, Dolk H. Termination of pregnancy for fetal anomaly after 23 weeks of gestation: a European register‐based study. BJOG 2010;117:660–666.Objective To determine the prevalence of termination of pregnancy for fetal anomaly (TOPFA) after 23 weeks of gestation in European countries, and describe the spectrum of anomalies for which late TOPFA is recorded.Design Population‐based study.Setting Twelve European countries.Population Nineteen registries of congenital anomaly in 12 European countries between 2000 and 2005. The number of total births covered was 2 695 832.Methods TOPFAs in singleton pregnancies from the European Surveillance of Congenital Anomalies and Twins (EUROCAT) database.Main outcome measures The prevalence of TOPFA and type of anomaly.Results There were 10 233 TOPFAs, 678 (6.6%) of which were performed at 24 weeks or more. The rate of TOPFA before 24 weeks was 3.4 per 1000 births, at 24–25 weeks 0.14 per 1000 births and at 26 weeks or more 0.11 per 1000 births. There was significant variation in the prevalence of TOPFA at ≥24 weeks between countries (P < 0.001), with all countries in the range 0–0.55 per 1000 births, except France (Paris) at 2.65 per 1000 births. The large majority of late TOPFAs had a gestational age of 24–27 weeks (516/678, 76%). The proportion of TOPFAs from 24 weeks or more varied by type of anomaly, with 4% of all TOPFAs for chromosomal anomalies and 9% of all TOPFAs for nonchromosomal anomalies resulting in late TOPFA (P < 0.001). For transposition of the great arteries, single ventricle, hypoplastic left heart and hydrocephaly, the percentage of late TOPFA was 12–23%. The median time interval between diagnosis and late TOPFA was 2 weeks for most anomalies, but longer (≥5 weeks) for diaphragmatic hernia, omphalocoele, arthrogryposis multiplex and Turner’s syndrome.Conclusion Late TOPFA is rare in Europe, and varies in prevalence between countries. Compared with earlier TOPFA, late TOPFA is more often performed for a nonchromosomal isolated major structural anomaly and less often for a fetus with a chromosomal syndrome or multiple anomalies.

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“…The malformations constitute the most frequent indication for termination of pregnancy. This group include different pathologies in which skeletal system is a small percentage variable between 6% and 16% [30][31][32]. Although most of the TA referred to our laboratory came from private centre with no medical or anatomic record, we have diagnosed 30% of TA (5 skeletal dysplasias and 1 triploidy) from 20 cases.…”

Section: Discussionmentioning

confidence: 99%

Prenatal diagnosis of skeletal dysplasia due to FGFR3 gene mutations: a 9-year experience

Trujillo-Tiebas

Fenollar-Cortés

Lorda‐Sánchez

et al. 2009

J Assist Reprod Genet

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Purpose Prenatal diagnosis with ultrasound findings compatible with skeletal dysplasia due to FGFR3 mutations over a 9 year period in pregnancies and abortuses. Methods 54 samples were studied. Aneuploidy studies were carried out on all samples. By sequencing analysis, we determined mutations for achondroplasia (ACH), hypochondroplasia (HCH), and type I and type II tanathophoric dysplasia (TD). Results 2 chorionic villi samples had a G380R mutation due to a mother with ACH; 4 amniotic fluid samples with TDs in which the foetuses had micromelia plus hypoplastic thoraces; 5 samples from abortuses with TDs. Neither ACH nor HCH occurred in sporadic cases. Conclusions Molecular studies in ongoing pregnancies are indicated in cases with an affected parent, a family history with positive molecular studies (maternal anxiety), and when the US finding demonstrates micromelia with a hypoplastic thorax. A protocol for tissues of abortuses should include an X-ray, pathologic anatomy, and genetic studies.

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Trends in elective terminations of pregnancy between 1989 and 2000 in a French county (the Isère)

Cited by 50 publications

References 17 publications

Trends in fetal indications for termination of pregnancy between 2002 and 2010 at a tertiary referral centre

Trends in fetal indications for termination of pregnancy between 2002 and 2010 at a tertiary referral centre

Termination of pregnancy for fetal anomaly after 23 weeks of gestation: a European register‐based study

Prenatal diagnosis of skeletal dysplasia due to FGFR3 gene mutations: a 9-year experience

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