Trends in emergency hospital admissions in England due to adverse drug reactions: 2008-2015

Veeren, Jennifer C; Weiss, Marjorie

doi:10.1111/jphs.12160

Cited by 50 publications

(41 citation statements)

References 18 publications

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“…This study demonstrated a significant increase of 5.8% per annum of ADR‐related hospitalisations in NSW, with the age‐adjusted incidence rate of ADR‐related hospitalisations nearly doubled over 13 years. The observed increasing pattern was consistent with previous findings in Western Australia, England, the United States and Spain . Alarmingly, study cases with severe comorbid conditions and in‐hospital deaths also increased over time, in comparison with a fairly steady trend of all‐cause in‐hospital deaths in Australia (crude rates from 346.7 per 100 000 in 2005–2006 to 328.4 in 2014–2015), reflecting an urgent need for clinical attention.…”

Section: Discussionsupporting

confidence: 88%

“…The observed increasing pattern was consistent with previous findings in Western Australia, England, the United States and Spain. 8,9,11,12 Alarmingly, study cases with severe comorbid conditions and in-hospital deaths also increased over time, in comparison with a fairly steady trend of allcause in-hospital deaths in Australia (crude rates from 346.7 per 100 000 in 2005-2006 to 328.4 in 2014-2015), 21 reflecting an urgent need for clinical attention. A previous study has reported that more than half of ADR-related hospitalisations could be prevented.…”

Section: Discussionmentioning

confidence: 99%

“…[2][3][4]7,8 Previous studies showed different patterns of ADR using routinely collected hospitalisation data. [8][9][10][11][12][13] Studies in the United States, 11 United Kingdom 9,10 and Portugal 13 indicated that the total number of ADR-related admissions increased over time, while other studies have shown a decreasing incidence of ADR. 8 Using Western Australia hospital inpatient data from 1981 to 2002, Burgess et al 12 reported an increase in the incidence rate of ADR from 2.5 to 12.9 per 1000 persons among patients aged 60 years and over.…”

Section: Introductionmentioning

confidence: 99%

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Trends in adverse drug reaction‐related hospitalisations over 13 years in New South Wales, Australia

Zhang

Gnjidic

et al. 2019

Internal Medicine Journal

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Background Adverse drug reactions (ADR) are severe problems in global public health, and result in high mortality and morbidity. Various trends of ADR‐related hospitalisations have been studied in many countries, while estimates of the trends in Australia are limited. Aim To examine trends in ADR‐related hospitalisations in New South Wales (NSW). Methods Data were extracted from the Admitted Patient Data Collection, a census of hospital separations in NSW. We estimated age‐adjusted rates of ADR‐related hospitalisation between 1 July 2001 and 30 June 2014 and rates by patient characteristics, main therapeutic medication groups and clinical condition groups that warranted the hospitalisation. We used the percentage change annualised estimator to evaluate rates over time. Results A total of 315 274 NSW residents admitted for urgent care of ADR was identified. The age‐adjusted rates of ADR‐related hospitalisations nearly doubled and increased by 5.8% (95% CI: 5.0–6.6%) per annum, with an in‐hospital death rate increase of 2.4% (1.6–3.3%). Agranulocytosis (2.7%), nausea and vomiting (2.4%) and heart failure (2.4%) were the most common conditions that led to ADR‐related hospitalisations over 13 years, with acute renal failure (1.4%) recently emerging as the leading adverse condition. Participants aged between 65 and 84 years accounted for nearly half of ADR hospitalisations (45.6%), with age‐adjusted rate increasing from 103.9 in 2001–2002 to 189.0 per 100 000 NSW residents in 2013–2014. Anticoagulants (13.5%) were the most common medications contributing to ADR‐related hospitalisation, followed by opioid analgesics (9.6%). Conclusion ADR‐related hospitalisation remains a population health burden, with significant increase over time. The findings call for continuing efforts to prevent ADR, especially among high‐risk populations, such as older people.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Trends in adverse drug reaction‐related hospitalisations over 13 years in New South Wales, Australia

Zhang

Gnjidic

et al. 2019

Internal Medicine Journal

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“…A recent systematic review of MRH in older adults found that between 17% to 51% of older adults experience MRH within 30 days of hospital discharge . In England, MRH is leading to an increasing number of hospital admissions . The direct health care costs of MRH in older adults following hospital discharge in England is conservatively estimated at £400 million annually, of which 90% of cost is attributable to hospital readmission …”

Section: Introductionmentioning

confidence: 99%

Do the 2015 Beers Criteria predict medication‐related harm in older adults? Analysis from a multicentre prospective study in the United Kingdom

Parekh

Ali

Davies

et al. 2019

Pharmacoepidemiology and Drug

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Purpose To investigate whether inappropriate prescribing, defined by the Beers Criteria, is associated with medication‐related harm (MRH), hospital admission, and mortality in older adults in England. Methods A multicentre, prospective cohort study recruited 1280 patients (median age 82 years) at hospital discharge. Patients were followed‐up in the community by pharmacists for 8 weeks to identify MRH (harm from adverse drug reactions, non‐adherence, and medication errors) and hospital admissions. One‐year mortality was determined using hospital records. Potentially inappropriate medications (PIMs) were determined using the 2015 version of the Beers criteria. Logistic regression was used to investigate the relationship between patients prescribed PIMs and adverse outcomes. Results Two hundred and seventy‐six patients (22%) were prescribed one or more PIMs at hospital discharge. The main PIM classes prescribed at hospital discharge were benzodiazepines and related drugs (30%) and antidepressants (27%). 1116 out of 1280 patients completed follow‐up and 413 (37%) experienced MRH. In 51 cases (12%), MRH was attributable to a PIM. There was no significant relationship between patients prescribed PIMs and overall MRH, hospital readmission or all‐cause one‐year mortality. Multiple PIMs at discharge was independently associated with an increased risk of ADR (OR 2.32, 95% CI 1.03‐5.23). Conclusion The prescribing of PIMs is common at hospital discharge of older adults in England. The 2015 Beers criteria have a limited clinical value to predict adverse outcomes following hospital discharge in this setting.

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“…Adverse drug reactions (ADRs) are associated with significant morbidity and mortality worldwide [1]. A study conducted to determine the number of ADR-related emergency hospital admissions in England reported an increase in ADR-led admissions from 1.2% in 2008 to 1.6% in 2015 [2]. In Saudi Arabia, the frequency of ADR-related hospital admissions was reported to be 6.1 per 100 admissions and 7.9 per 1000 patient days [3].…”

Section: Introductionmentioning

confidence: 99%

Assessing the impact of structured education on the knowledge of hospital pharmacists about adverse drug reactions and reporting methods in Saudi Arabia: an open-label randomised controlled trial

Cheema

Almualem

Basudan

et al. 2019

Drugs Ther Perspect

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Background Pharmacists have limited knowledge about adverse drug reactions (ADRs) in Saudi Arabia.Objective The aim of this study was to assess the impact of educational intervention on the knowledge of hospital pharmacists about ADRs. Methods This was a 3-month randomized controlled trial conducted in Saudi Arabia between January 2018 and March 2018. Participants in both groups were required to complete an online questionnaire at baseline and at 12-week follow-up. Participants in the intervention group received a structured information sheet about ADRs 2 weeks after the first assessment. The main outcome measure was difference in mean knowledge score about ADRs. Main outcome measure Difference in mean knowledge score about ADRs. Results A total of 46 participants were included in the study. At the 12-week follow-up, there was a significant improvement in the mean knowledge score (± standard deviation) of intervention participants from 7.67 (± 2.1) at baseline to 11.22 (± 0.4) (95% CI −4.5 to −2.5; p < 0.0001). The mean knowledge score of control participants remained unchanged at 6.71 (± 2.3) during both baseline and follow-up assessments. Conclusion ADR-specific education was associated with a significant improvement in the knowledge and understanding of pharmacists about ADRs and their methods of reporting.

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Trends in emergency hospital admissions in England due to adverse drug reactions: 2008-2015

Cited by 50 publications

References 18 publications

Trends in adverse drug reaction‐related hospitalisations over 13 years in New South Wales, Australia

Trends in adverse drug reaction‐related hospitalisations over 13 years in New South Wales, Australia

Do the 2015 Beers Criteria predict medication‐related harm in older adults? Analysis from a multicentre prospective study in the United Kingdom

Assessing the impact of structured education on the knowledge of hospital pharmacists about adverse drug reactions and reporting methods in Saudi Arabia: an open-label randomised controlled trial

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