Trends in gastroesophageal reflux disease research: A bibliometric and visualized study

Abstract

BackgroundGastroesophageal reflux disease (GERD), a disorder resulting from the retrograde flow of gastric contents into the esophagus, affects an estimated 10–30% of the Western population, which is characterized by multifactorial pathogenesis. Over the past few decades, there have been many aspects of uncertainty regarding GERD leading to an ongoing interest in the field as reflected by a large number of publications, whose heterogeneity and variable quality may present a challenge for researchers to measure their scientific impact, identify scientific collaborations, and to grasp actively researched themes in the GERD field. Accordingly, we aim to evaluate the knowledge structure, evolution of research themes, and emerging topics of GERD research between 2012 and 2022 with the help of bibliometric approaches.MethodsThe literature focusing on GERD from 2012 to 2022 was retrieved from the Science Citation Index Expanded of the Web of Science Core Collection. The overall publication performance, the most prolific countries or regions, authors, journals and resources-, knowledge- and intellectual-networking, as well as the co-citation analysis of references and keywords, were analyzed through Microsoft Office Excel 2019, CiteSpace, and VOSviewer.ResultsA total of 8,964 publications were included in the study. The USA published the most articles (3,204, 35.74%). Mayo Clin ranked first in the number of articles published (201, 2.24%). EDOARDO SAVARINO was the most productive author (86, 0.96%). The most productive journal in this field was SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES (304, 3.39%). AMERICAN JOURNAL OF GASTROENTEROLOGY had the most co-citations (4,953, 3.30%). Keywords with the ongoing strong citation bursts were transoral incision less fundoplication, eosinophilic esophagitis, baseline impedance, and functional heartburn.ConclusionFor the first time, we obtained deep insights into GERD research through bibliometric analysis. Findings in this study will be helpful for scholars seeking to understand essential information in this field and identify research frontiers.

Causal relationship analysis between 35 blood/urine metabolites and gastroesophageal reflux disease: A Mendelian randomization combined meta-analysis study

“…[32,33,36] As a potent antioxidant, abnormal urate metabolism may disrupt the redox balance, promoting inflammatory responses and exacerbating esophageal mucosal damage. [37] Additionally, elevated urate levels are closely associated with metabolic syndrome, which is considered a significant risk factor for GERD. [35] Factors such as insulin resistance, hyperglycemia, hypertension, and obesity in metabolic syndrome may increase GERD risk through various pathways.…”

Functional Food in Relation to Gastroesophageal Reflux Disease (GERD)

“…Poor lifestyles, including those characterized by unhealthy nutritional habits and a lack of physical activity, lead to an increase in the development of degenerative diseases and even death [ 82 ]. It has been estimated that 10–30% of the Western population suffers from degenerative diseases, including GERD [ 83 ]. This situation has forced people to prioritize their health, diet, and well-being.…”

Bibliometric and visualized analysis of resveratrol in anticancer investigations

“…Despite the substantial volume of resveratrol‐related anticancer literature published annually, researchers face a significant challenge in sifting through this extensive body of work, requiring them to assess the quality of articles and gauge their scientific impact and importance. In such circumstances, bibliometric analysis methods prove invaluable for evaluating articles across various disciplines (Zhang et al., 2022 ). This study aims to employ bibliometric methods to examine the trends and knowledge landscape in resveratrol‐related anticancer research over the past two decades.…”