Trends in gestational choriocarcinoma: a 27-year perspective*1

Abstract

Gestational choriocarcinoma incidence rates have declined and survivals have improved, but blacks continue to have higher incidence and lower survival rates.

Relative Effects of Age, Race, and Stage on Mortality in Gestational Choriocarcinoma

“…It is less likely that inadequacy of postmolar surveillance guidelines contributed significantly because clear guidelines exist for diagnosis of and surveillance after GTD. 15 Our results affirm many of the findings of an earlier SEER analysis by Smith et al, 9 who evaluated patients with choriocarcinoma from 1973 to 1999. Like these authors, we also showed that most patients with choriocarcinoma are diagnosed from ages 20 to 39 years and that there is no difference in the distribution of choriocarcinoma by stage and race.…”

“…The analysis of age-adjusted cancer incidence, however, was limited to patients diagnosed from 2000 to 2014 because data from 1973 to 1999 have been previously evaluated. 9 Patients with choriocarcinoma were identified on the basis of their International Classification of Diseases for Oncology, Third Edition (ICD-O-3) code. 10 Patients with the histologic code for choriocarcinoma (9100/3) were included.…”

“…Like these authors, we also showed that most patients with choriocarcinoma are diagnosed from ages 20 to 39 years and that there is no difference in the distribution of choriocarcinoma by stage and race. 9 Their analysis also that showed that increasing age at diagnosis and advanced-stage disease were associated with worse survival. 9 Interestingly, although our study adds an additional 14 years of data, 5-year OS is almost identical for both studies (89.5% vs 89.6%).…”

“…9 Their analysis also that showed that increasing age at diagnosis and advanced-stage disease were associated with worse survival. 9 Interestingly, although our study adds an additional 14 years of data, 5-year OS is almost identical for both studies (89.5% vs 89.6%). 9 Our study provides new insight into the age-adjusted incidence of choriocarcinoma.…”

Association of Aberrant Methylation at Promoter Regions of Tumor Suppressor Genes with Placental Pathologies

“…Deregulation in this pseudomalignant phenotype results in the development of GTDs [42] and PE [43] which involves excessive or shallow invasion of trophoblasts into myometrium, respectively. Recent studies have suggested existence of common epigenetic mechanisms between trophoblasts and cancer cells, regulating proliferative, migratory and invasive properties [40,44].…”