Trends in hospitalization and death rates among patients with head and neck cancer in Spain, 2009 to 2019

Carazo-Casas, Carlos; Gil-Prieto, Ruth; Hernández‐Barrera, Valentín; Miguel, Ángel Gil de

doi:10.1080/21645515.2022.2082192

Cited by 7 publications

(5 citation statements)

References 70 publications

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“…HPV was identified as a significant positive prognostic factor for females with some solid tumors ( Preissner et al, 2022 ). Our study found that females have higher FANCE expression in HNSC, these may help explain the lower incidence compared to males ( Carazo-Casas et al, 2022 ).…”

Section: Discussionsupporting

confidence: 55%

Pan-cancer analysis of the prognostic and immunological role of Fanconi anemia complementation group E

et al. 2023

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Fanconi anemia (FA) genes contribute to tumorigenesis by regulating DNA repair. Despite its importance for assembly and functionality of the FA core complex, no pan-cancer analysis of FANCE was performed. We aimed to provide a comprehensive understanding of the role of FANCE in cancers. Based on The Cancer Genome Atlas (TCGA), Cancer Cell Line Encyclopedia (CCLE), Genotype Tissue-Expression (GTEx), Human Protein Atlas (HPA), Gene Expression Omnibus (GEO), and Cancer Single-cell Atlas (CancerSEA) databases, we investigated the carcinogenicity of FANCE using various bioinformatics methods, including FANCE expression and prognosis, immune invasion, tumor mutation burden, microsatellite instability, and neoantigens. We monitored Fance mutations in mice that caused tumorigenesis. FANCE expression and activity scores were upregulated in 15 and 21 cancers. High expression of FANCE affected shorter overall survival (OS) in seven cancers and longer overall survival in three cancers. It was correlated with shorter overall survival and progression-free interval (PFI) in endometrial cancer and longer overall survival and PFI in cervical cancer. FANCE expression negatively correlated with stromal/immune scores in 21 cancers including cervical cancer, endometrial cancer, and ovarian cancer. FANCE expression negatively correlated with CD8 T cells in endometrial cancer and positively correlated with M1 macrophages in cervical cancer, possibly related to cancer prognosis. FANCE positively correlated with immune checkpoint inhibitors PD-1, PD-L1, and CTLA4 in endometrial cancer and ovarian cancer. FANCE expression positively correlated with microsatellite instability, tumor mutational burden, and neoantigens in 7, 22, and five cancers, especially in endometrial cancer, potentially increasing the effectiveness of immunotherapy. Single-cell sequencing data showed FANCE was primarily expressed in cancer cells in cervical and ovarian cancer, and in fibroblasts in endometrial cancer. Fance heterozygous mutant mice had increased tumor incidences and shorter overall survival and tumor-free survival (TFS) than Fance homozygous mutant mice and wild-type mice. Conclusively, FANCE potential to serve as a biomarker for cancer prognosis and may predict cancer immunotherapy responses. Fance heterozygous mutant resulted in increased tumorigenesis and poor prognosis in mice.

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Section: Discussionsupporting

confidence: 55%

Pan-cancer analysis of the prognostic and immunological role of Fanconi anemia complementation group E

et al. 2023

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“…Considering that cervical cancer is actually the fourth most common female cancer [8], particularly Pathogens 2023, 12, 725 2 of 11 among women aged between 35 and 44 years [9], with over 300,000 yearly deaths estimated, it represents a heavy burden for healthcare services. In addition, other HPV-related conditions showed a substantial burden of disease across highly developed countries, with trends varying by country [10][11][12]. Genital warts represent another HPV-related condition that mainly affects younger patients (mainly caused by genotypes 6 and 11), with an annual hospitalization rate of over 8/100,000 inhabitants [13].…”

Section: Introductionmentioning

confidence: 99%

The Burden of HPV-Related Hospitalizations: Analysis of Hospital Discharge Records from the Years 2015–2021 from a Southern Italian Region

Cedrone

Giovanni

et al. 2023

Pathogens

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(1) Background: The human papillomavirus (HPV) is the most common agent related to sexually transmitted infections in the general population. Its genotypes are classified into two main classes, high-risk genotypes and low-risk genotypes, according to their capacity to induce cancers. The low-risk class (types 6 and 11) is associated with anogenital and genital lesions. The high-risk class is responsible for up to 4.5% of all new cancer cases yearly. The aim of this study was to evaluate the incidence of HPV-related hospitalizations and its trend in a southern Italian region for the years 2015–2021. (2) Methods: This was a retrospective study performed in the Abruzzo region, Italy. All admissions for the period 2015–2021 were extracted from the hospital discharge record (HDR). (3) Results: During the study period (2015–2021), a total of 5492 hospitalizations attributable to HPV infection occurred in the Abruzzo region, Italy. A significant number of admissions were related to cervical cancer (3386 cases) and genital warts (638 cases). The trend declined for all diagnoses except for penile cancer admissions. Considering the first year of the pandemic (year 2020), a decrease in the standardized incidence of the majority of the diseases considered was reported, particularly among cases of cervical cancer. (4) Conclusions: HPV-related hospitalizations decreased in Abruzzo during study period. These results could be useful to LHAs and policy-makers in improving vaccination coverage and screening adherence.

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“… 25 There is a greater difference from that of other cancers, such as pharyngeal cancer, whose cost was estimated to be 5,955€ in men and 5,541€ in hospitalized women; laryngeal cancer, whose estimated cost is 7,066€ in men and 7,118€ in hospitalized women; or oral cavity cancer, whose estimated cost is 7,486€ in men and 6,984€ in women hospitalized. 26 …”

Section: Discussionmentioning

confidence: 99%

Hospitalization burden associated with anus and penis neoplasm in Spain (2016-2020)

Fernandez-Alonso,

Gil-Prieto,

Amado-Anton-Pacheco

et al. 2024

Human Vaccines & Immunotherapeutics

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In 2020, there were approximately 50,865 anal cancer cases and 36,068 penile cancer cases worldwide. HPV is considered the main causal agent for the development of anal cancer and one of the causal agents responsible for the development of penile cancer. The aim of this epidemiological, descriptive, retrospective study was to describe the burden of hospitalization associated with anal neoplasms in men and women and with penis neoplasms in men in Spain from 2016 to 2020. The National Hospital Data Surveillance System of the Ministry of Health, Conjunto Mínimo Básico de Datos, provided the discharge information used in this observational retrospective analysis. A total of 3,542 hospitalizations due to anal cancer and 4,270 hospitalizations due to penile cancer were found; For anal cancer, 57.4% of the hospitalizations occurred in men, and these hospitalizations were also associated with significantly younger mean age, longer hospital stays and greater costs than those in women. HIV was diagnosed in 11.19% of the patients with anal cancer and 1.74% of the patients with penile cancer. The hospitalization rate was 2.07 for men and 1.45 for women per 100,000 in anal cancer and of 4.38 per 100,000 men in penile cancer. The mortality rate was 0.21 for men and 0.12 for women per 100,000 in anal cancer and 0.31 per 100.000 men in penile cancer and the case-fatality rate was 10.07% in men and 8,26% in women for anal cancer and 7.04% in penile cancer. HIV diagnosis significantly increased the cost of hospitalization. For all the studied diagnoses, the median length of hospital stays and hospitalization cost increased with age. Our study offers relevant data on the burden of hospitalization for anal and penile cancer in Spain. This information can be useful for future assessment on the impact of preventive measures, such as screening or vaccination in Spain.

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Trends in hospitalization and death rates among patients with head and neck cancer in Spain, 2009 to 2019

Cited by 7 publications

References 70 publications

Pan-cancer analysis of the prognostic and immunological role of Fanconi anemia complementation group E

Pan-cancer analysis of the prognostic and immunological role of Fanconi anemia complementation group E

The Burden of HPV-Related Hospitalizations: Analysis of Hospital Discharge Records from the Years 2015–2021 from a Southern Italian Region

Hospitalization burden associated with anus and penis neoplasm in Spain (2016-2020)

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