Trends in Hospitalization Associated With Traumatic Brain Injury in a Publicly Insured Population, 1992–2002

Colantonio, Angela; Croxford, Ruth; Farooq, Samina; Laporte, Audrey; Coyte, Peter C.

doi:10.1097/ta.0b013e3181715d66

Cited by 64 publications

(84 citation statements)

References 10 publications

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“…Our study confirms the common opinion between Internists about their speculation that TBIs are increased in their wards over the years, especially when considering the very old patients. In the last decade, the overall number of admissions for TBIs reduced in Tuscany as trends reported in literature (6-8), but when considering patients over 75 years the overall hospital admissions for TBIs increased both in numbers (2469 in 2003, 2949 in 2012) and in burden of patients over 75 injured on total patients (25,4% in 2003, 45.2%in 2012), our results being overlapping to literature (1,(6)(7)(8)(9)(10)(11)(12). Concomitantly, the burden of admissions for TBIs in Internal Medicine wards increased and this increasing was totally dependent from that occurred in patients over 75 years.…”

Section: Discussionsupporting

confidence: 40%

Traumatic Brain Injuries in Internal Medicine Wards: An Emerging Challenge Needing for a Call to Action

Masotti¹

2015

AJIM

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Section: Discussionsupporting

confidence: 40%

Traumatic Brain Injuries in Internal Medicine Wards: An Emerging Challenge Needing for a Call to Action

Masotti¹

2015

AJIM

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“…54 A study from Ontario using ICD-9 codes to identify hospitalized patients with TBI found no reduction in mortality between 1992 and 2001. 55 Administrative databases have also been used to identify patients with hemorrhagic stroke from across Canada and to compare outcomes between 1982-1983 and 1991-1992. Statistically significant improvements in casefatality rates were reported for patients with ICH but not SAH.…”

Section: Discussionmentioning

confidence: 99%

Declining mortality in neurocritical care patients: a cohort study in Southern Alberta over eleven years

Kramer

Zygun

2013

Can J Anesth/J Can Anesth

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“…Traumatic brain injury (TBI) is currently one of the major causes of disability, particularly in children and young adults in developed countries (1). These injuries have both short-and long-term effects on individuals, their families and society.…”

Section: Introductionmentioning

confidence: 99%

Transplantation of neural stem cells enhances expression of synaptic protein and promotes functional recovery in a rat model of traumatic brain injury

Shi

2011

Mol Med Report

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Abstract. Transplantion of neural stem cells (NSCs) hasshown promise for the treatment of traumatic brain injury (TBI). Although the functional mechanisms underlying transplant-mediated recovery following TBI have yet to be determined, previous studies demonstrated that transplanted NSCs may respond to the release of specific neurotransmitters, and/or the production of factors that promote neuronal growth. Therefore, we hypothesize that the direct transplantation of NSCs into the injured brain enhanced the expression of synaptic protein and regeneration-associated protein, which may be responsible for promoting functional recovery in a rat model of TBI. Our results showed that NSC transplant significantly improved neurological motor function in selected behavioral tests compared to saline control rats. Our data showed that the number of surviving cells engrafted into the rats was 4.1±0.9% of engrafted cells at 8 weeks post-transplantation, with 11.4±1.6% βⅢ-tubulin-immunopositive cells of these cells. RT-PCR and Western blot analysis demonstrated that the expression of synaptophysin (SYP) and regeneration-associated protein (GAP43) in the injured brain of NSC-transplanted rats was significantly increased compared to the saline control rats during the experimental period. These data suggest that NSCs transplanted directly into the injured brain are capable of surviving, differentiating into neurons and promoting functional recovery in a rat model of TBI. Engrafted NSCs increase the expression of SYP and GAP43 in the injured brain of NSC-transplanted rats, which is suggested as one of the mechanisms underlying the improved functional recovery on motor behavior due to the transplantation of NSCs following TBI.

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Trends in Hospitalization Associated With Traumatic Brain Injury in a Publicly Insured Population, 1992–2002

Abstract: Hospitalizations for TBI involve fewer mild injuries over time and are highest in the oldest segment of the population.

Cited by 64 publications

References 10 publications

Traumatic Brain Injuries in Internal Medicine Wards: An Emerging Challenge Needing for a Call to Action

Traumatic Brain Injuries in Internal Medicine Wards: An Emerging Challenge Needing for a Call to Action

Declining mortality in neurocritical care patients: a cohort study in Southern Alberta over eleven years

Transplantation of neural stem cells enhances expression of synaptic protein and promotes functional recovery in a rat model of traumatic brain injury

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