Trends in Hospitalizations with Antibiotic-Resistant Infections: U.S., 1997–2006

Mainous, Arch G.; Díaz, Vanessa A.; Matheson, Eric M.; Gregorie, Seth H.; Hueston, William J.

doi:10.1177/003335491112600309

Cited by 41 publications

(41 citation statements)

References 14 publications

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“…Analysis of the prevalence of antibiotic use showed that metronidazole was the most prevalent antibiotic, prescribed for 35.6% of We have witnessed a decline in the numbers of new antibiotics being marketed in recent years and the medical community is struggling to preserve our current armamentarium (12). Investigators and health-care officials in the United States and Europe are working on a more uniform approach to antibiotic stewardship.…”

Section: Resultsmentioning

confidence: 99%

Changes in antibiotic use in a general surgery unit over a 5-year period

Ayazi

Khabaz

Ayazi

et al. 2015

Easter Mediterr Health J

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This increase was mainly due to increases in the use of antibiotics for treatment of infections; the prophylactic use of antibiotics did not show a significant increase. There was an increase in the consumption of ceftriaxone, imipenem, cefalotin, metronidazole and vancomycin, a decrease in the use of erythromycin and ceftazidime and no change in the use of ciprofloxacin and clindamycin. Ceftriaxone showed the greatest increase (5.1-fold) and erythromycin the sharpest decrease (8-fold) in use.

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Section: Resultsmentioning

confidence: 99%

Changes in antibiotic use in a general surgery unit over a 5-year period

Ayazi

Khabaz

Ayazi

et al. 2015

Easter Mediterr Health J

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“…Bacterial 16S rDNA Note: 1 The base "i" designates inosine; "K" denotes G/T; "R" indicates A/G; "Y" indicates C/T.…”

Section: Quantitative Pcr Primers/probes and Plasmidsmentioning

confidence: 99%

“…In the United States, the number of ARB-related hospitalizations continues to increase [1] with an estimated cost of up to $30 billion annually [2]. In recent years the importance of ARB has come to the forefront of many scientific disciplines including environmental microbiology.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Primary, Secondary, and Tertiary Wastewater Treatment Processes on Antibiotic Resistance Gene (ARG) Concentrations in Solid and Dissolved Wastewater Fractions

Quach-Cu

Herrera-Lynch

Marciniak

et al. 2018

Water

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Abstract:Wastewater treatment plants (WWTPs) have been identified as potential sources of antibiotic resistance genes (ARGs) but the effects of tertiary wastewater treatment processes on ARGs have not been well characterized. Therefore, the objective of this study was to determine the fate of ARGs throughout a tertiary-stage WWTP. Two ARGs, sul1 and bla, were quantified via quantitative polymerase chain reaction (qPCR) in solids and dissolved fractions of raw sewage, activated sludge, secondary effluent and tertiary effluent from a full-scale WWTP. Tertiary media filtration and chlorine disinfection were studied further with the use of a pilot-scale media filter. Results showed that both genes were reduced at each successive stage of treatment in the dissolved fraction. The solids-associated ARGs increased during activated sludge stage and were reduced in each subsequent stage. Overall reductions were approximately four log 10 with the tertiary media filtration and disinfection providing the largest decrease. The majority of ARGs were solids-associated except for in the tertiary effluent. There was no evidence for positive selection of ARGs during treatment. The removal of ARGs by chlorine was improved by filtration compared to unfiltered, chlorinated secondary effluent. This study demonstrates that tertiary-stage WWTPs with disinfection can provide superior removal of ARGs compared to secondary treatment alone.

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“…Furthermore, it is not only the high prevalence of resistance among bacteria that poses a threat, but also the rapid increase in levels of resistance. Mainous et al (2011) analysed the tendencies of antibiotic resistance in US hospitals during a 10-year period between 1997 and 2006. The results of the study showed a twofold increase in the number of infectionrelated hospitalizations with antibiotic resistance.…”

Section: Methicillin-resistant S Aureusmentioning

confidence: 99%

Inhibition of methicillin-resistant Staphylococcus aureus (MRSA) by antimicrobial peptides (AMPs) and plant essential oils

Zouhir

Jridi

Nefzi

et al. 2016

Pharmaceutical Biology

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Trends in Hospitalizations with Antibiotic-Resistant Infections: U.S., 1997–2006

Abstract: Antibiotic-resistant infections are becoming increasingly commonplace in hospitalizations in the U.S., with a steady upward trend between 1997 and 2006. Antibiotic-resistant infections are increasingly being seen in younger patients and those without health insurance.

Cited by 41 publications

References 14 publications

Changes in antibiotic use in a general surgery unit over a 5-year period

Changes in antibiotic use in a general surgery unit over a 5-year period

The Effect of Primary, Secondary, and Tertiary Wastewater Treatment Processes on Antibiotic Resistance Gene (ARG) Concentrations in Solid and Dissolved Wastewater Fractions

Inhibition of methicillin-resistant Staphylococcus aureus (MRSA) by antimicrobial peptides (AMPs) and plant essential oils

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