Trends in incidence and predictions of cutaneous melanoma across Europe up to 2015

Arnold, Melina; Holterhues, Cynthia; Hollestein, Loes; Coebergh, Jan Willem; Nijsten, Tamar; Pukkala, Eero; Holleczek, Bernd; Tryggvadóttír, Laufey; Comber, Harry; Bento, Maria José; Diba, Ch S; Micallef, R.; Primic-Žakelj, Maja; Izarzugaza, M. Isabel; Perucha, Josefina; Marcos‐Gragera, Rafael; Galcerán, Jaume; Ardanáz, Eva; Schaffar, Robin; Pring, Andy; Vries, Esther de

doi:10.1111/jdv.12236

Cited by 197 publications

(180 citation statements)

References 33 publications

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“…To be eligible for assessment, websites had to meet the following inclusion criteria: (1) contain information on immunotherapy referring to melanoma, (2) contain at least 5 sentences of information, (3) be accessible for free and for all users (including patients and lay persons), (4) information is provided in German language. Websites were excluded if they were solely patient exchange platforms, advertising websites, conference or congress websites (e.g.…”

Section: Inclusion and Exclusion Criteriamentioning

confidence: 99%

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Exploring the Most Visible German Websites on Melanoma Immunotherapy: A Web-Based Analysis

et al. 2018

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Section: Inclusion and Exclusion Criteriamentioning

confidence: 99%

“…Melanoma incidence has been increasing worldwide [1,2]. In Germany, it accounts for about 4% of all cancers and is the fifth most common malignancy [3].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Most Visible German Websites on Melanoma Immunotherapy: A Web-Based Analysis

et al. 2018

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“…Cutaneous melanoma is a common malignant skin cancer and its incidence is increasing steeply [1]. Melanomas have a poor prognosis because they are highly invasive and metastasize rapidly; in addition, they are resistant to various conventional therapies.…”

Section: Introductionmentioning

confidence: 99%

ING4 Inhibits Proliferation and Induces Apoptosis in Human Melanoma A375 Cells via the Fas/Caspase-8 Apoptosis Pathway

Cheng²,

Wang³

et al. 2016

Dermatology

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Background: Inhibitor of growth 4 (ING4) plays a role in regulating the cell cycle, apoptosis, cell invasion and migration, but the mechanisms involved remain to be elucidated. Objective: To explore how ING4 affects human malignant melanoma A375 cells. Methods: Recombinant lentiviral vectors (A375/pLenO-GTP-ING4) were constructed and transfected into A375 cells (experimental group). The impact of ING4 on the proliferation and apoptosis of A375 cells was investigated in in vitro and in vivo experiments in mice using the MTT assay and flow cytometry. Results: In the experimental group, optical density was lower and apoptotic cells were more frequent from days 2-5 (p = 0.000 and p < 0.01); there were smaller xenografts and more apoptotic cells in mice (all p < 0.05); moreover, increased levels of Fas, cleaved caspase-8 and caspase-3, and decreased levels of FasL and procyclic acidic repetitive protein were observed in vitro and in vivo. Conclusion: ING4 might suppress proliferation and enhance apoptosis in human malignant melanoma cells by activating Fas-induced apoptosis in a caspase-8-dependent pathway.

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“…This was followed by two studies in Whites in Cape Town which showed an increase in incidence in both men and women when figures from 1990 to 1995 were compared with that from 2001 to 2003 (10,11). Reported data from all of South Africa indicate that the incidence in the White population is similar to that found in European countries (18) …”

Section: Incidence Of CM In the White And Black African Population Grmentioning

confidence: 86%

The Epidemiology of Cutaneous Melanoma in the White and Black African Population Groups in South Africa

Norval

Wright

2017

Cutaneous Melanoma: Etiology and Therapy

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Abstract:In this chapter, two South African population groups, White and Black African, are compared with regard to cutaneous melanoma (CM). The incidence of CM in Black Africans is about 10% of that in Whites, explained at least in part by the protection offered by cutaneous melanin. The incidence has probably risen in Whites over the past 40 years but seems to be unchanged in Black Africans. The commonest CM subtype in Whites is superficial spreading; it occurs on various body sites, the most frequent being the trunk in males and the lower leg/hip in women. Most CMs in both male and female Black Africans are found on the lower leg and/or hip with a significant proportion being acral lentiginous melanoma, a subtype rarely seen in Whites. Risk factors including exposure to the sun, trauma, human immunodeficiency virus infection, albinism, age, and genetics are summarized and are likely to differ between the two population groups. The stage of CM at diagnosis tends to be more advanced in Black Africans than in Whites and, similarly, the survival rates are considerably lower in Black Africans. Reasons for the differences in CM between the two population groups are suggested.

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Trends in incidence and predictions of cutaneous melanoma across Europe up to 2015

Abstract: Incidence rates of melanoma are expected to continue rising. These trends are worrying in terms of disease burden, particularly in eastern European countries.

Cited by 197 publications

References 33 publications

Exploring the Most Visible German Websites on Melanoma Immunotherapy: A Web-Based Analysis

Exploring the Most Visible German Websites on Melanoma Immunotherapy: A Web-Based Analysis

ING4 Inhibits Proliferation and Induces Apoptosis in Human Melanoma A375 Cells via the Fas/Caspase-8 Apoptosis Pathway

The Epidemiology of Cutaneous Melanoma in the White and Black African Population Groups in South Africa

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