Trends in Incidence of Cancers of the Oral Cavity and Pharynx — United States 2007–2016

Ellington, Taylor D; Henley, S. Jane; Senkomago, Virginia; O’Neil, Michael; Wilson, Reda; Singh, Sonia; Thomas, Cheryll C.; Wu, Manxia; Richardson, Lisa C.

doi:10.15585/mmwr.mm6915a1

Cited by 124 publications

(130 citation statements)

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“…Moreover, because of their rarity, subclassification in distinct groups would have lowered the power of the study, compromising our ability to detect clinically significant differences. 30 Because of the rarity of buccal SCC in North America, 3 a limited number of patients (N = 52) were identified in our tertiary institution over a 25-year period. The small number of cases and terminal events required that we limit the number of variables included in our multivariate analysis.…”

Section: Limitationsmentioning

confidence: 99%

“…1 Although the incidence of oral cancer in Europe and North America has been increasing, localization of the SCC epicenter in the buccal mucosa remains relatively rare, representing approximately 5%-10% of oral SCCs. 2,3 Buccal SCC is characterized by aggressive locoregional behavior. 4 Previous studies have shown that buccal SCCs should be treated with surgery, 5 with adjuvant radiotherapy reserved for patients with advanced or more aggressive disease.…”

Section: Introductionmentioning

confidence: 99%

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Clinicopathologic predictors of survival in buccal squamous cell carcinoma

Marinelli

Chatzopoulos

Marinelli

et al. 2020

J Oral Pathology Medicine

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Background: Buccal squamous cell carcinoma (SCC) is a locoregionally aggressive malignancy, representing a small subset of oral cancers in North America. We investigated the prognostic value of several clinicopathologic factors in a cohort of patients diagnosed with buccal SCC. Methods: Between years 1992 and 2017, 52 patients were diagnosed with conventional buccal SCC. Archival surgical pathology material was retrospectively reviewed for reportable findings according to the latest reporting guidelines published by the College of American Pathologists. Clinical data were obtained through chart review. Results: The majority of patients were of older age, current or past smokers, and without specific gender predilection. Most presented at a clinically advanced stage and were treated with surgery alone, or surgery followed by adjuvant radiotherapy. The tumor recurred in about 40% of patients, and almost half of the patients died from the disease by the end of the follow-up period. The worst pattern of invasion (WPOI) was associated with greater depth of invasion (DOI) (P = .031) and perineural invasion (P < .001). In univariate analyses, older age (P = .004), positive nodal status (P = .047), lymphovascular invasion (P = .012), perineural invasion (P = .05), and WPOI-5 (P = .015) were adverse predictors of 5-year overall survival (OS). In multivariate analysis, older age (P = .011), WPOI-5 (P < .001), and perineural invasion (P = .001) remained statistically significant independent prognosticators of worse 5-year OS. Conclusions: Older age, WPOI-5, and perineural invasion are significant prognosticators of worse OS. WPOI is associated with DOI, a finding which may have important implications for the pathogenesis and biologic behavior of the disease.

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Section: Limitationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinicopathologic predictors of survival in buccal squamous cell carcinoma

Marinelli

Chatzopoulos

Marinelli

et al. 2020

J Oral Pathology Medicine

View full text Add to dashboard Cite

show abstract

“…A recent report by the Centers for Disease Control and Prevention (CDC) documents the trends in oral and pharyngeal cancers (OPC) in the United States over a 10-year period, 2007-2016. 1 The rate of OPC began to increase in 1999 and has been increasing ever since. The age-adjusted rate in 2007 was 10.89/100,000 compared with 11.7/100,000 in 2016 (TABLE 1 1 ).…”

Section: Taking Steps To Slow the Upswing In Oral And Pharyngeal Cancersmentioning

confidence: 99%

“…In absolute numbers, there were 35,076 cases in 2007 and 44,419 in 2016. 1 The trends in incidence of OPC vary by anatomical site, with some increasing and others declining.…”

Section: Taking Steps To Slow the Upswing In Oral And Pharyngeal Cancersmentioning

confidence: 99%

“…The rising overall incidence of OPC is being driven by increases in HPV-related cancers at an average rate of 2.1% per year, while the rates at non-HPV-associated sites have been declining by 0.4% per year. 1 It is also important to appreciate that HPV causes cancer at other anatomical sites (TABLE 2 2 ) and is responsible for an estimated 35,000 cancers per year. 2 Other trends of note in all OPCs combined are increasing rates among non-Hispanic whites and Asian-Pacific Islanders; decreasing rates among Hispanics and African Americans; increasing rates among males with no real change in rates among females; increasing rates in those 50 to 79 years of age; decreasing rates among those 40 to 49 years of age; and unchanged rates in other age groups.…”

Section: Taking Steps To Slow the Upswing In Oral And Pharyngeal Cancersmentioning

confidence: 99%

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