Trends in Invasive Methicillin-Resistant <i>Staphylococcus aureus</i> Infections

Iwamoto, Martha; Mu, Yi; Lynfield, Ruth; Bulens, Sandra N.; Nadle, Joelle; Aragon, Deborah; Petit, Susan; Ray, Susan M.; Harrison, Lee H.; Dumyati, Ghinwa; Townes, John M.; Schaffner, William; Gorwitz, Rachel J.; Lessa, Fernanda C.

doi:10.1542/peds.2013-1112

Cited by 112 publications

(105 citation statements)

References 36 publications

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“…26 In a study using diagnostic coding data, the estimated incidence of MRSA osteoarticular infections was 2.38 per 1000 admissions in 2012. 2 Previous studies at our own institution from 2001 to 2004 had observed that >60% of S aureus osteomyelitis was secondary to MRSA 3 ; other centers have also noted a predominance of MRSA among osteoarticular infections.…”

Section: Discussionmentioning

confidence: 99%

Role of Operative or Interventional Radiology-Guided Cultures for Osteomyelitis

et al. 2016

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BACKGROUND AND OBJECTIVE: Acute hematogenous osteomyelitis (AHO) is a severe infection in children. Drainage of purulent collections in bones provides specimens for culture as well as therapeutic benefit. Interventional radiology (IR)-guided procedures may serve as a less invasive means of culture in select patients. We examined the impact of IR and surgically obtained cultures in the diagnosis and management of AHO.

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Section: Discussionmentioning

confidence: 99%

Role of Operative or Interventional Radiology-Guided Cultures for Osteomyelitis

et al. 2016

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“…5,6 However, this does not appear to be the trend in the pediatric population. 7 Because colonization is a major independent risk factor for infection, 3 we conducted this metaanalysis to estimate the burden of MRSA colonization on admission to NICUs and PICUs, study its significance on MRSA-associated infections, and model its course over time.…”

Section: Discussionmentioning

confidence: 99%

“…4 A number of reports indicate that the trends in MRSA invasive infections in high-risk adult populations are decreasing. 5,6 The epidemiology of MRSA invasive infections among critically ill neonates and children seems to follow a distinct course, [7][8][9] with data on MRSA outbreaks in NICUs increasingly being published. [10][11][12][13] In this systematic review and meta-analysis, we estimate the prevalence of MRSA colonization among patients upon admission to the NICU and PICU, review the time trends, and study the significance of MRSA colonization in this population.…”

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confidence: 99%

MRSA Colonization and Risk of Infection in the Neonatal and Pediatric ICU: A Meta-analysis

Zervou

Zacharioudakis

Ziakas³

et al. 2014

Pediatrics

110

102

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BACKGROUND AND OBJECTIVE: Methicillin-resistant Staphylococcus aureus (MRSA) is a significant cause of morbidity and mortality in NICUs and PICUs. Our objective was to assess the burden of MRSA colonization on admission, study the time trends, and examine the significance of MRSA colonization in this population. METHODS:PubMed and Embase databases were consulted. Studies that reported prevalence of MRSA colonization on ICU admission were selected. Two authors independently extracted data on MRSA colonization and infection. RESULTS:We identified 18 suitable articles and found an overall prevalence of MRSA colonization of 1.9% (95% confidence interval [CI] 1.3%-2.6%) on admission to the NICU or PICU, with a stable trend over the past 12 years. Interestingly, 5.8% (95% CI 1.9%-11.4%) of outborn neonates were colonized with MRSA on admission to NICU, compared with just 0.2% (95% CI 0.0%-0.9%) of inborn neonates (P = .01). The pooled acquisition rate of MRSA colonization was 4.1% (95% CI 1.2%-8.6%) during the NICU and PICU stay and was as high as 6.1% (95% CI 2.8%-10.6%) when the NICU population was studied alone. There was a relative risk of 24.2 (95% CI 8.9-66.0) for colonized patients to develop a MRSA infection during hospitalization. CONCLUSIONS:In the NICU and PICU, there are carriers of MRSA on admission, and MRSA colonization in the NICU is almost exclusively associated with outborn neonates. Importantly, despite infection control measures, the acquisition rate is high, and patients colonized with MRSA on admission are more likely to suffer a MRSA infection during hospitalization.

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“…6,14,15 While the incidence of healthcareand community-associated infections caused by methicillinresistant Staphylococcus aureus (MRSA) has been decreasing in adults in the United States in recent years, 16 a similar trend has not been observed among children. 17 Additionally, multidrug-resistant gram-negative pathogens continue to emerge and are increasing in healthcare settings, 18 which has heightened the awareness of healthcare personnel and the public of the importance of preventing patient-to-patient transmission of multidrug-resistant organisms (MDROs). 5,19,20 3.…”

Section: Introductionmentioning

confidence: 99%

Infection Prevention and Control Guideline for Cystic Fibrosis: 2013 Update

Saiman

Siegel

LiPuma

et al. 2014

Infect. Control Hosp. Epidemiol.

352

382

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The 2013 Infection Prevention and Control (IP&C) Guideline for Cystic Fibrosis (CF) was commissioned by the CF Foundation as an update of the 2003 Infection Control Guideline for CF. During the past decade, new knowledge and new challenges provided the following rationale to develop updated IP&C strategies for this unique population:1. The need to integrate relevant recommendations from evidence-based guidelines published since 2003 into IP&C practices for CF. These included guidelines from the Centers for Disease Control and Prevention (CDC)/Healthcare Infection Control Practices Advisory Committee (HICPAC), the World Health Organization (WHO), and key professional societies, including the Infectious Diseases Society of America (IDSA) and the Society for Healthcare Epidemiology of America (SHEA). During the past decade, new evidence has led to a renewed emphasis on source containment of potential pathogens and the role played by the contaminated healthcare environment in the transmission of infectious agents. Furthermore, an increased understanding of the importance of the application of implementation science, monitoring adherence, and feedback principles has been shown to increase the effectiveness of IP&C guideline recommendations.2. Experience with emerging pathogens in the non-CF population has expanded our understanding of droplet transmission of respiratory pathogens and can inform IP&C strategies for CF. These pathogens include severe acute respiratory syndrome coronavirus and the 2009 influenza A H1N1. Lessons learned about preventing transmission of methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant gram-negative pathogens in non-CF patient populations also can inform IP&C strategies for CF.

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Trends in Invasive Methicillin-Resistant Staphylococcus aureus Infections

Cited by 112 publications

References 36 publications

Role of Operative or Interventional Radiology-Guided Cultures for Osteomyelitis

Role of Operative or Interventional Radiology-Guided Cultures for Osteomyelitis

MRSA Colonization and Risk of Infection in the Neonatal and Pediatric ICU: A Meta-analysis

Infection Prevention and Control Guideline for Cystic Fibrosis: 2013 Update

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