Trends in maternal age distribution and the live birth prevalence of Down’s syndrome in England and Wales: 1938–2010

Wu, Jianhua; Morris, Joan K.

doi:10.1038/ejhg.2012.288

Cited by 52 publications

(50 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is unclear whether this evolution relates to screening performance, changed population characteristics and/or parental choice. A rising trend of T21 affected pregnancies is observed in many other countries; however LBPD mostly remains constant …”

Section: Discussionmentioning

confidence: 91%

Contingent non-invasive prenatal testing: an opportunity to improve non-genetic aspects of fetal aneuploidy screening

2015

View full text Add to dashboard Cite

Today, in Belgium and in many other countries, full NIPT screening is considered too expensive for immediate introduction into the national fetal aneuploidy screening program. Contingent NIPT screening is both clinically and economically beneficial. A temporary contingent NIPT protocol allows for reinvesting economic savings into optimization of those screening aspects, which are to be maintained in parallel to full NIPT screening.

show abstract

Section: Discussionmentioning

confidence: 91%

Contingent non-invasive prenatal testing: an opportunity to improve non-genetic aspects of fetal aneuploidy screening

2015

View full text Add to dashboard Cite

show abstract

“…3 The estimated prevalence is likely to be accurate before screening for Down's syndrome in England and Wales started in the early 1970s. From 1970 to 1989, maternal age was the main factor used to identify pregnant women judged to be at a high risk of a Down's syndrome pregnancy.…”

Section: Live Birth Prevalence Of Down's Syndromementioning

confidence: 99%

The population prevalence of Down’s syndrome in England and Wales in 2011

Morris

2013

Eur J Hum Genet

Self Cite

View full text Add to dashboard Cite

There is uncertainty over the population prevalence of people with Down's syndrome in England and Wales. This study aimed to estimate the population prevalence of Down's syndrome in England and Wales in 2011. A meta-analysis of published survival rates of people with Down's syndrome from 1938 to 2010 was conducted and the results were applied to the estimated numbers of babies born with Down's syndrome since 1938 in England and Wales. An estimated 37 090 people had Down's syndrome in England and Wales in 2011, a population prevalence of 0.66 per 1000 people; 650 under 1, 2673 aged 1-5, 7115 aged 5-18, 12 819 aged 19-40, 10 626 aged 41-55 and 3207 aged 56 and older. The average life expectancy for babies with Down's syndrome born in 2011 was 51 years and the median life expectancy was 58 years. This study provides clarity on the number of people with Down's syndrome in England and Wales. Owing to sudden increases in the survival of babies with Down's syndrome in the 1950s there are a large proportion of people with Down's syndrome who are in their 40s. These people have an increased risk of developing dementia in the future and services should be aware of their potential needs.

show abstract

“…However, live birth prevalence remained stable at around 1.0 per 1000 over these periods (Loane et al . ; Wu & Morris ). In the DS group aged 35–40 years, the drop in population prevalence may therefore be primarily attributed to the availability of selective abortion, combined with low mean maternal age around 1975 (Wu & Morris ).…”

Section: Discussionmentioning

confidence: 99%